Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 18:48, 10 November 2007 (UTC)[edit]
Proteins without matches (22)[edit]
Proteins with a High Potential Match (3)[edit]
Created (7)[edit]
Manual Inspection (Page not found) (18)[edit]
Protein Status Grid - Date: 18:48, 10 November 2007 (UTC)[edit]
Vebose Log - Date: 18:48, 10 November 2007 (UTC)[edit]
- INFO: Beginning work on ACVR1B... {November 10, 2007 12:08:10 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACVR1B image.jpg {November 10, 2007 12:08:23 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:08:41 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACVR1B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rw8.
| PDB = {{PDB2|1rw8}}
| Name = Activin A receptor, type IB
| HGNCid = 172
| Symbol = ACVR1B
| AltSymbols =; ACTRIB; ACVRLK4; ALK4; SKR2
| OMIM = 601300
| ECnumber =
| Homologene = 20906
| MGIid = 1338944
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016361 |text = activin receptor activity, type I}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019838 |text = growth factor binding}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}} {{GNF_GO|id=GO:0048185 |text = activin binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001942 |text = hair follicle development}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007178 |text = transmembrane receptor protein serine/threonine kinase signaling pathway}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045648 |text = positive regulation of erythrocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 91
| Hs_Ensembl = ENSG00000135503
| Hs_RefseqProtein = NP_004293
| Hs_RefseqmRNA = NM_004302
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 50494095
| Hs_GenLoc_end = 50677124
| Hs_Uniprot = P36896
| Mm_EntrezGene = 11479
| Mm_Ensembl = ENSMUSG00000000532
| Mm_RefseqmRNA = NM_007395
| Mm_RefseqProtein = NP_031421
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101002159
| Mm_GenLoc_end = 101040635
| Mm_Uniprot = Q3TZF1
}}
}}
'''Activin A receptor, type IB''', also known as '''ACVR1B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.<ref>{{cite web | title = Entrez Gene: ACVR1B activin A receptor, type IB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Welt CK |title=The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. |journal=Curr. Opin. Obstet. Gynecol. |volume=14 |issue= 3 |pages= 317-23 |year= 2002 |pmid= 12032389 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADCYAP1R1... {November 10, 2007 12:08:41 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:09:13 AM PST}
- CREATED: Created new protein page: ADCYAP1R1 {November 10, 2007 12:09:20 AM PST}
- INFO: Beginning work on BANF1... {November 10, 2007 10:34:11 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BANF1 image.jpg {November 10, 2007 10:34:43 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:35:02 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BANF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ci4.
| PDB = {{PDB2|1ci4}}, {{PDB2|1qck}}, {{PDB2|2bzf}}, {{PDB2|2ezx}}, {{PDB2|2ezy}}, {{PDB2|2ezz}}, {{PDB2|2odg}}
| Name = Barrier to autointegration factor 1
| HGNCid = 17397
| Symbol = BANF1
| AltSymbols =; BAF; BCRP1; D14S1460; MGC111161
| OMIM = 603811
| ECnumber =
| Homologene = 2866
| MGIid = 1346330
| GeneAtlas_image1 = PBB_GE_BANF1_210125_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0015074 |text = DNA integration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8815
| Hs_Ensembl = ENSG00000175334
| Hs_RefseqProtein = NP_003851
| Hs_RefseqmRNA = NM_003860
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 65526126
| Hs_GenLoc_end = 65528192
| Hs_Uniprot = O75531
| Mm_EntrezGene = 23825
| Mm_Ensembl = ENSMUSG00000024844
| Mm_RefseqmRNA = NM_001038231
| Mm_RefseqProtein = NP_001033320
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 5364641
| Mm_GenLoc_end = 5366651
| Mm_Uniprot = O54962
}}
}}
'''Barrier to autointegration factor 1''', also known as '''BANF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene was identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The endogenous function of the protein is unknown. The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during mitosis. This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated polypeptide 2, a component of the nuclear lamina.<ref>{{cite web | title = Entrez Gene: BANF1 barrier to autointegration factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8815| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goldberg M, Harel A, Gruenbaum Y |title=The nuclear lamina: molecular organization and interaction with chromatin. |journal=Crit. Rev. Eukaryot. Gene Expr. |volume=9 |issue= 3-4 |pages= 285-93 |year= 2000 |pmid= 10651245 |doi= }}
*{{cite journal | author=Segura-Totten M, Wilson KL |title=BAF: roles in chromatin, nuclear structure and retrovirus integration. |journal=Trends Cell Biol. |volume=14 |issue= 5 |pages= 261-6 |year= 2004 |pmid= 15130582 |doi= 10.1016/j.tcb.2004.03.004 }}
*{{cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26-43 |year= 2005 |pmid= 15875659 |doi= }}
*{{cite journal | author=Van Maele B, Busschots K, Vandekerckhove L, ''et al.'' |title=Cellular co-factors of HIV-1 integration. |journal=Trends Biochem. Sci. |volume=31 |issue= 2 |pages= 98-105 |year= 2006 |pmid= 16403635 |doi= 10.1016/j.tibs.2005.12.002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on C1R... {November 10, 2007 12:09:20 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein C1R image.jpg {November 10, 2007 12:09:34 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:09:44 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_C1R_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1apq.
| PDB = {{PDB2|1apq}}, {{PDB2|1gpz}}, {{PDB2|1md7}}, {{PDB2|1md8}}
| Name = Complement component 1, r subcomponent
| HGNCid = 1246
| Symbol = C1R
| AltSymbols =;
| OMIM = 216950
| ECnumber =
| Homologene = 1313
| MGIid = 1355313
| Function = {{GNF_GO|id=GO:0003815 |text = complement component C1r activity}} {{GNF_GO|id=GO:0003816 |text = complement component C1s activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 715
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001724
| Hs_RefseqmRNA = NM_001733
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 50909
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001005373
| Mm_RefseqProtein = XP_001005373
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Complement component 1, r subcomponent''', also known as '''C1R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CACNA1H... {November 10, 2007 10:35:02 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:35:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calcium channel, voltage-dependent, T type, alpha 1H subunit
| HGNCid = 1395
| Symbol = CACNA1H
| AltSymbols =; CACNA1HB; Cav3.2; FLJ90484
| OMIM = 607904
| ECnumber =
| Homologene = 56913
| MGIid = 1928842
| GeneAtlas_image1 = PBB_GE_CACNA1H_205845_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008332 |text = low voltage-gated calcium channel activity}}
| Component = {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0007520 |text = myoblast fusion}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8912
| Hs_Ensembl = ENSG00000196557
| Hs_RefseqProtein = NP_001005407
| Hs_RefseqmRNA = NM_001005407
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 1143739
| Hs_GenLoc_end = 1211772
| Hs_Uniprot = O95180
| Mm_EntrezGene = 58226
| Mm_Ensembl = ENSMUSG00000024112
| Mm_RefseqmRNA = NM_021415
| Mm_RefseqProtein = NP_067390
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 25101887
| Mm_GenLoc_end = 25161385
| Mm_Uniprot = Q6PE92
}}
}}
'''Calcium channel, voltage-dependent, T type, alpha 1H subunit''', also known as '''CACNA1H''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).<ref>{{cite web | title = Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8912| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Crunelli V, Tóth TI, Cope DW, ''et al.'' |title=The 'window' T-type calcium current in brain dynamics of different behavioural states. |journal=J. Physiol. (Lond.) |volume=562 |issue= Pt 1 |pages= 121-9 |year= 2005 |pmid= 15498803 |doi= 10.1113/jphysiol.2004.076273 }}
*{{cite journal | author=Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J |title=International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 411-25 |year= 2006 |pmid= 16382099 |doi= 10.1124/pr.57.4.5 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCNU... {November 10, 2007 10:36:54 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:37:30 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cyclin U
| HGNCid = 18576
| Symbol = CCNU
| AltSymbols =; FLJ22422; UDG2; UNG2
| OMIM = 607752
| ECnumber =
| Homologene = 50171
| MGIid = 2145534
| GeneAtlas_image1 = PBB_GE_CCNU_210021_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004844 |text = uracil DNA N-glycosylase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10309
| Hs_Ensembl = ENSG00000152669
| Hs_RefseqProtein = NP_001019763
| Hs_RefseqmRNA = NM_001024592
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 54562740
| Hs_GenLoc_end = 54565265
| Hs_Uniprot = P22674
| Mm_EntrezGene = 218630
| Mm_Ensembl = ENSMUSG00000042417
| Mm_RefseqmRNA = XM_127523
| Mm_RefseqProtein = XP_127523
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 114108776
| Mm_GenLoc_end = 114111654
| Mm_Uniprot = P0C242
}}
}}
'''Cyclin U''', also known as '''CCNU''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Caradonna S, Muller-Weeks S |title=The nature of enzymes involved in uracil-DNA repair: isoform characteristics of proteins responsible for nuclear and mitochondrial genomic integrity. |journal=Curr. Protein Pept. Sci. |volume=2 |issue= 4 |pages= 335-47 |year= 2002 |pmid= 12369930 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD79B... {November 10, 2007 12:09:44 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:10:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD79b molecule, immunoglobulin-associated beta
| HGNCid = 1699
| Symbol = CD79B
| AltSymbols =; B29; IGB
| OMIM = 147245
| ECnumber =
| Homologene = 521
| MGIid = 96431
| GeneAtlas_image1 = PBB_GE_CD79B_205297_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019815 |text = B cell receptor complex}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0050853 |text = B cell receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 974
| Hs_Ensembl = ENSG00000007312
| Hs_RefseqProtein = NP_000617
| Hs_RefseqmRNA = NM_000626
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 59359832
| Hs_GenLoc_end = 59363446
| Hs_Uniprot = P40259
| Mm_EntrezGene = 15985
| Mm_Ensembl = ENSMUSG00000040592
| Mm_RefseqmRNA = NM_008339
| Mm_RefseqProtein = NP_032365
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 106127431
| Mm_GenLoc_end = 106130760
| Mm_Uniprot = Q4FJP4
}}
}}
'''CD79b molecule, immunoglobulin-associated beta''', also known as '''CD79B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.<ref>{{cite web | title = Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=974| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reth M |title=Antigen receptors on B lymphocytes. |journal=Annu. Rev. Immunol. |volume=10 |issue= |pages= 97-121 |year= 1992 |pmid= 1591006 |doi= 10.1146/annurev.iy.10.040192.000525 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CEACAM5... {November 10, 2007 12:10:16 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 12:10:28 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:10:42 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CEACAM5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e07.
| PDB = {{PDB2|1e07}}
| Name = Carcinoembryonic antigen-related cell adhesion molecule 5
| HGNCid = 1817
| Symbol = CEACAM5
| AltSymbols =; CD66e; CEA; DKFZp781M2392
| OMIM = 114890
| ECnumber =
| Homologene =
| MGIid =
| Function = {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1048
| Hs_Ensembl = ENSG00000105388
| Hs_RefseqProtein = NP_004354
| Hs_RefseqmRNA = NM_004363
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 46904408
| Hs_GenLoc_end = 46923112
| Hs_Uniprot = P06731
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Carcinoembryonic antigen-related cell adhesion molecule 5''', also known as '''CEACAM5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CHM... {November 10, 2007 12:10:42 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:11:35 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Choroideremia (Rab escort protein 1)
| HGNCid = 1940
| Symbol = CHM
| AltSymbols =; DXS540; FLJ38564; GGTA; HSD-32; MGC102710; REP-1; TCD
| OMIM = 300390
| ECnumber =
| Homologene = 334
| MGIid = 892979
| GeneAtlas_image1 = PBB_GE_CHM_207099_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004663 |text = Rab-protein geranylgeranyltransferase activity}} {{GNF_GO|id=GO:0005084 |text = Rab escort protein activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}}
| Component = {{GNF_GO|id=GO:0005968 |text = Rab-protein geranylgeranyltransferase complex}}
| Process = {{GNF_GO|id=GO:0001568 |text = blood vessel development}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0018348 |text = protein amino acid geranylgeranylation}} {{GNF_GO|id=GO:0043087 |text = regulation of GTPase activity}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1121
| Hs_Ensembl = ENSG00000188419
| Hs_RefseqProtein = NP_000381
| Hs_RefseqmRNA = NM_000390
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 85002841
| Hs_GenLoc_end = 85189222
| Hs_Uniprot = P24386
| Mm_EntrezGene = 12662
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_991490
| Mm_RefseqProtein = XP_996584
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Choroideremia (Rab escort protein 1)''', also known as '''CHM''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The choroideremia gene encodes for a protein, the Rab escort protein-1 (REP1), which is involved in membrane trafficking.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CHM choroideremia (Rab escort protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1121| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CLDN4... {November 10, 2007 12:13:36 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:14:24 AM PST}
- CREATED: Created new protein page: CLDN4 {November 10, 2007 12:14:34 AM PST}
- INFO: Beginning work on COIL... {November 10, 2007 10:31:30 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:32:25 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Coilin
| HGNCid = 2184
| Symbol = COIL
| AltSymbols =; CLN80; p80-coilin
| OMIM = 600272
| ECnumber =
| Homologene = 3413
| MGIid = 104842
| GeneAtlas_image1 = PBB_GE_COIL_203654_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COIL_203653_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0001674 |text = female germ cell nucleus}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0015030 |text = Cajal body}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8161
| Hs_Ensembl = ENSG00000121058
| Hs_RefseqProtein = NP_004636
| Hs_RefseqmRNA = NM_004645
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 52370562
| Hs_GenLoc_end = 52393410
| Hs_Uniprot = P38432
| Mm_EntrezGene = 12812
| Mm_Ensembl = ENSMUSG00000033983
| Mm_RefseqmRNA = NM_016706
| Mm_RefseqProtein = NP_057915
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 88790039
| Mm_GenLoc_end = 88807703
| Mm_Uniprot =
}}
}}
'''Coilin''', also known as '''COIL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.<ref>{{cite web | title = Entrez Gene: COIL coilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8161| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL4A6... {November 10, 2007 12:11:36 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:12:48 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type IV, alpha 6
| HGNCid = 2208
| Symbol = COL4A6
| AltSymbols =; MGC88184
| OMIM = 303631
| ECnumber =
| Homologene = 48050
| MGIid = 2152695
| GeneAtlas_image1 = PBB_GE_COL4A6_211473_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL4A6_213992_at_tn.png
| GeneAtlas_image3 = PBB_GE_COL4A6_210945_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1288
| Hs_Ensembl = ENSG00000197565
| Hs_RefseqProtein = NP_001838
| Hs_RefseqmRNA = NM_001847
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 107285493
| Hs_GenLoc_end = 107569383
| Hs_Uniprot = Q14031
| Mm_EntrezGene = 94216
| Mm_Ensembl = ENSMUSG00000031273
| Mm_RefseqmRNA = NM_053185
| Mm_RefseqProtein = NP_444415
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 136412396
| Mm_GenLoc_end = 136720444
| Mm_Uniprot =
}}
}}
'''Collagen, type IV, alpha 6''', also known as '''COL4A6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.<ref>{{cite web | title = Entrez Gene: COL4A6 collagen, type IV, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1288| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FRS2... {November 10, 2007 10:37:30 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FRS2 image.jpg {November 10, 2007 10:38:04 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:38:22 AM PST}
- CREATED: Created new protein page: FRS2 {November 10, 2007 10:38:30 AM PST}
- INFO: Beginning work on GABARAP... {November 10, 2007 10:38:30 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GABARAP image.jpg {November 10, 2007 10:39:02 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:39:19 AM PST}
- CREATED: Created new protein page: GABARAP {November 10, 2007 10:39:28 AM PST}
- INFO: Beginning work on MAP3K8... {November 10, 2007 12:12:48 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:13:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitogen-activated protein kinase kinase kinase 8
| HGNCid = 6860
| Symbol = MAP3K8
| AltSymbols =; COT; EST; ESTF; FLJ10486; TPL2; Tpl-2; c-COT
| OMIM = 191195
| ECnumber =
| Homologene = 3812
| MGIid = 1346878
| GeneAtlas_image1 = PBB_GE_MAP3K8_205027_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1326
| Hs_Ensembl = ENSG00000107968
| Hs_RefseqProtein = NP_005195
| Hs_RefseqmRNA = NM_005204
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 30762872
| Hs_GenLoc_end = 30790768
| Hs_Uniprot = P41279
| Mm_EntrezGene = 26410
| Mm_Ensembl = ENSMUSG00000024235
| Mm_RefseqmRNA = NM_007746
| Mm_RefseqProtein = NP_031772
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 4331325
| Mm_GenLoc_end = 4352951
| Mm_Uniprot = Q3T9M0
}}
}}
'''Mitogen-activated protein kinase kinase kinase 8''', also known as '''MAP3K8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.<ref>{{cite web | title = Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1326| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCOA4... {November 10, 2007 10:30:37 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:31:21 AM PST}
- CREATED: Created new protein page: NCOA4 {November 10, 2007 10:31:30 AM PST}
- INFO: Beginning work on SLC4A4... {November 10, 2007 10:32:25 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:34:11 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 4, sodium bicarbonate cotransporter, member 4
| HGNCid = 11030
| Symbol = SLC4A4
| AltSymbols =; DKFZp781H1314; HNBC1; KNBC; NBC1; NBC2; SLC4A5; hhNMC; pNBC
| OMIM = 603345
| ECnumber =
| Homologene = 55776
| MGIid = 1927555
| GeneAtlas_image1 = PBB_GE_SLC4A4_203908_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC4A4_210738_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC4A4_210739_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005452 |text = inorganic anion exchanger activity}} {{GNF_GO|id=GO:0008510 |text = sodium:bicarbonate symporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006820 |text = anion transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8671
| Hs_Ensembl = ENSG00000080493
| Hs_RefseqProtein = NP_003750
| Hs_RefseqmRNA = NM_003759
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 72271867
| Hs_GenLoc_end = 72656663
| Hs_Uniprot = Q9Y6R1
| Mm_EntrezGene = 54403
| Mm_Ensembl = ENSMUSG00000060961
| Mm_RefseqmRNA = NM_018760
| Mm_RefseqProtein = NP_061230
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 90009311
| Mm_GenLoc_end = 90310338
| Mm_Uniprot = O88343
}}
}}
'''Solute carrier family 4, sodium bicarbonate cotransporter, member 4''', also known as '''SLC4A4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Romero MF, Boron WF |title=Electrogenic Na+/HCO3- cotransporters: cloning and physiology. |journal=Annu. Rev. Physiol. |volume=61 |issue= |pages= 699-723 |year= 1999 |pmid= 10099707 |doi= 10.1146/annurev.physiol.61.1.699 }}
*{{cite journal | author=Soleimani M, Burnham CE |title=Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes. |journal=Kidney Int. |volume=57 |issue= 2 |pages= 371-84 |year= 2000 |pmid= 10652014 |doi= 10.1046/j.1523-1755.2000.00857.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SSTR5... {November 10, 2007 12:14:34 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:15:03 AM PST}
- CREATED: Created new protein page: SSTR5 {November 10, 2007 12:15:10 AM PST}
- INFO: Beginning work on TCOF1... {November 10, 2007 12:15:10 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:24:26 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Treacher Collins-Franceschetti syndrome 1
| HGNCid = 11654
| Symbol = TCOF1
| AltSymbols =; MFD1; treacle
| OMIM = 606847
| ECnumber =
| Homologene = 68049
| MGIid = 892003
| GeneAtlas_image1 = PBB_GE_TCOF1_202384_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TCOF1_202385_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6949
| Hs_Ensembl = ENSG00000070814
| Hs_RefseqProtein = NP_000347
| Hs_RefseqmRNA = NM_000356
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 149717410
| Hs_GenLoc_end = 149760063
| Hs_Uniprot =
| Mm_EntrezGene = 21453
| Mm_Ensembl = ENSMUSG00000024613
| Mm_RefseqmRNA = NM_011552
| Mm_RefseqProtein = NP_035682
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 60939133
| Mm_GenLoc_end = 60974286
| Mm_Uniprot = O08784
}}
}}
'''Treacher Collins-Franceschetti syndrome 1''', also known as '''TCOF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only three of them have been characterized to date.<ref>{{cite web | title = Entrez Gene: TCOF1 Treacher Collins-Franceschetti syndrome 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6949| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Splendore A, Silva EO, Alonso LG, ''et al.'' |title=High mutation detection rate in TCOF1 among Treacher Collins syndrome patients reveals clustering of mutations and 16 novel pathogenic changes. |journal=Hum. Mutat. |volume=16 |issue= 4 |pages= 315-22 |year= 2000 |pmid= 11013442 |doi= 10.1002/1098-1004(200010)16:4<315::AID-HUMU4>3.0.CO;2-H }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNK2... {November 10, 2007 10:35:39 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TNK2 image.jpg {November 10, 2007 10:36:32 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:36:54 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cf4.
| PDB = {{PDB2|1cf4}}, {{PDB2|1u46}}, {{PDB2|1u4d}}, {{PDB2|1u54}}
| Name = Tyrosine kinase, non-receptor, 2
| HGNCid = 19297
| Symbol = TNK2
| AltSymbols =; ACK; ACK1; FLJ44758; FLJ45547; p21cdc42Hs
| OMIM = 606994
| ECnumber =
| Homologene = 4224
| MGIid = 1858308
| GeneAtlas_image1 = PBB_GE_TNK2_203838_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TNK2_203839_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005095 |text = GTPase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10188
| Hs_Ensembl = ENSG00000061938
| Hs_RefseqProtein = NP_001010938
| Hs_RefseqmRNA = NM_001010938
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 197074633
| Hs_GenLoc_end = 197120352
| Hs_Uniprot = Q07912
| Mm_EntrezGene = 51789
| Mm_Ensembl = ENSMUSG00000022791
| Mm_RefseqmRNA = NM_016788
| Mm_RefseqProtein = NP_058068
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 32583504
| Mm_GenLoc_end = 32601030
| Mm_Uniprot = Q0Z844
}}
}}
'''Tyrosine kinase, non-receptor, 2''', also known as '''TNK2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.<ref>{{cite web | title = Entrez Gene: TNK2 tyrosine kinase, non-receptor, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10188| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TUBA1A... {November 10, 2007 10:27:36 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TUBA1A image.jpg {November 10, 2007 10:30:22 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:30:37 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TUBA1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ffx.
| PDB = {{PDB2|1ffx}}, {{PDB2|1ia0}}, {{PDB2|1jff}}, {{PDB2|1sa0}}, {{PDB2|1sa1}}, {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}, {{PDB2|2hxf}}, {{PDB2|2hxh}}
| Name = Tubulin, alpha 1a
| HGNCid = 20766
| Symbol = TUBA1A
| AltSymbols =; B-ALPHA-1; FLJ25113; TUBA3
| OMIM = 602529
| ECnumber =
| Homologene = 68498
| MGIid = 98869
| GeneAtlas_image1 = PBB_GE_TUBA1A_209118_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TUBA1A_201090_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TUBA1A_209251_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7846
| Hs_Ensembl = ENSG00000167552
| Hs_RefseqProtein = NP_006000
| Hs_RefseqmRNA = NM_006009
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 47864847
| Hs_GenLoc_end = 47869153
| Hs_Uniprot = Q71U36
| Mm_EntrezGene = 22142
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011653
| Mm_RefseqProtein = NP_035783
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tubulin, alpha 1a''', also known as '''TUBA1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.<ref>{{cite web | title = Entrez Gene: TUBA1A tubulin, alpha 1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7846| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Desai A, Mitchison TJ |title=Tubulin and FtsZ structures: functional and therapeutic implications. |journal=Bioessays |volume=20 |issue= 7 |pages= 523-7 |year= 1998 |pmid= 9722999 |doi= 10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L }}
*{{cite journal | author=Oakley BR |title=An abundance of tubulins. |journal=Trends Cell Biol. |volume=10 |issue= 12 |pages= 537-42 |year= 2001 |pmid= 11121746 |doi= }}
*{{cite journal | author=Dutcher SK |title=The tubulin fraternity: alpha to eta. |journal=Curr. Opin. Cell Biol. |volume=13 |issue= 1 |pages= 49-54 |year= 2001 |pmid= 11163133 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TYROBP... {November 10, 2007 10:24:26 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:25:04 AM PST}
- CREATED: Created new protein page: TYROBP {November 10, 2007 10:25:12 AM PST}
- INFO: Beginning work on TYRP1... {November 10, 2007 10:25:12 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:26:00 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tyrosinase-related protein 1
| HGNCid = 12450
| Symbol = TYRP1
| AltSymbols =; CAS2; CATB; GP75; TRP; TYRP; b-PROTEIN
| OMIM = 115501
| ECnumber =
| Homologene = 464
| MGIid = 98881
| GeneAtlas_image1 = PBB_GE_TYRP1_205694_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042470 |text = melanosome}}
| Process = {{GNF_GO|id=GO:0006583 |text = melanin biosynthetic process from tyrosine}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0043473 |text = pigmentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7306
| Hs_Ensembl = ENSG00000107165
| Hs_RefseqProtein = NP_000541
| Hs_RefseqmRNA = NM_000550
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 12683435
| Hs_GenLoc_end = 12700290
| Hs_Uniprot = P17643
| Mm_EntrezGene = 22178
| Mm_Ensembl = ENSMUSG00000005994
| Mm_RefseqmRNA = NM_031202
| Mm_RefseqProtein = NP_112479
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 80305461
| Mm_GenLoc_end = 80322950
| Mm_Uniprot = Q3UFK6
}}
}}
'''Tyrosinase-related protein 1''', also known as '''TYRP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sarangarajan R, Boissy RE |title=Tyrp1 and oculocutaneous albinism type 3. |journal=Pigment Cell Res. |volume=14 |issue= 6 |pages= 437-44 |year= 2002 |pmid= 11775055 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on UCN... {November 10, 2007 10:26:00 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:26:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Urocortin
| HGNCid = 12516
| Symbol = UCN
| AltSymbols =; MGC129974; MGC129975; UI; UROC
| OMIM = 600945
| ECnumber =
| Homologene = 2515
| MGIid = 1276123
| GeneAtlas_image1 = PBB_GE_UCN_206072_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7349
| Hs_Ensembl = ENSG00000163794
| Hs_RefseqProtein = NP_003344
| Hs_RefseqmRNA = NM_003353
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 27383769
| Hs_GenLoc_end = 27384634
| Hs_Uniprot = P55089
| Mm_EntrezGene = 22226
| Mm_Ensembl = ENSMUSG00000038676
| Mm_RefseqmRNA = NM_021290
| Mm_RefseqProtein = NP_067265
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 31414570
| Mm_GenLoc_end = 31415476
| Mm_Uniprot = Q14A76
}}
}}
'''Urocortin''', also known as '''UCN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.<ref>{{cite web | title = Entrez Gene: UCN urocortin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7349| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ZYX... {November 10, 2007 10:26:40 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:27:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zyxin
| HGNCid = 13200
| Symbol = ZYX
| AltSymbols =; ESP-2; HED-2
| OMIM = 602002
| ECnumber =
| Homologene = 31164
| MGIid = 103072
| GeneAtlas_image1 = PBB_GE_ZYX_200808_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZYX_215706_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7791
| Hs_Ensembl = ENSG00000159840
| Hs_RefseqProtein = NP_001010972
| Hs_RefseqmRNA = NM_001010972
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 142788482
| Hs_GenLoc_end = 142798322
| Hs_Uniprot = Q15942
| Mm_EntrezGene = 22793
| Mm_Ensembl = ENSMUSG00000029860
| Mm_RefseqmRNA = NM_011777
| Mm_RefseqProtein = NP_035907
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 42279476
| Mm_GenLoc_end = 42289753
| Mm_Uniprot = Q62523
}}
}}
'''Zyxin''', also known as '''ZYX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.<ref>{{cite web | title = Entrez Gene: ZYX zyxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7791| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
end log.
