Barrier to autointegration factor 1

BANF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QCK, 2ODG, 1CI4, 2BZF, 2EZY, 2EZZ, 2EZX
Identifiers
Aliases	BANF1, BAF, BCRP1, D14S1460, NGPS, Barrier to autointegration factor 1, BAF nuclear assembly factor 1
External IDs	OMIM: 603811 MGI: 1346330 HomoloGene: 2866 GeneCards: BANF1
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 66,002,228 bp End 66,004,149 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 5,414,666 bp End 5,417,196 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right uterine tube gastrocnemius muscle ascending aorta right coronary artery right adrenal gland left uterine tube canal of the cervix left coronary artery left adrenal gland Top expressed in somite medial ganglionic eminence maxillary prominence thymus hand morula atrium abdominal wall yolk sac otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding protein C-terminus binding enzyme binding protein homodimerization activity protein N-terminus binding LEM domain binding identical protein binding Cellular component cytoplasm extracellular exosome condensed chromosome nucleus chromosome nucleoplasm cytosol nuclear envelope Biological process mitotic nuclear membrane reassembly response to virus mitotic nuclear membrane disassembly DNA integration establishment of integrated proviral latency viral process nuclear transport negative regulation of viral genome replication chromosome segregation chromosome condensation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8815 23825 Ensembl ENSG00000175334 ENSMUSG00000024844 UniProt O75531 O54962 RefSeq (mRNA) NM_003860 NM_001143985 NM_001038231 NM_001286608 NM_011793 RefSeq (protein) NP_001137457 NP_003851 NP_001033320 NP_001273537 NP_035923 Location (UCSC) Chr 11: 66 – 66 Mb Chr 19: 5.41 – 5.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Barrier-to-autointegration factor is a protein that in humans is encoded by the BANF1 gene. It is a member of the barrier-to-autointegration factor family of proteins.

Function

The protein encoded by this gene was identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The endogenous function of the protein is unknown. The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during mitosis. This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated polypeptide 2, a component of the nuclear lamina. It also associates with the LEM Domain containing proteins LAP2, Emerin, and MAN1. The protein's DNA binding ability is modulated by ATP concentration.

Interactions

Barrier to autointegration factor 1 has been shown to interact with Thymopoietin.

Clinical relevance

Mutations in this gene have been shown to cause hereditary progeroid syndrome.

See also

• Retroviral integration

Further reading

• Goldberg M, Harel A, Gruenbaum Y (2000). "The nuclear lamina: molecular organization and interaction with chromatin". Crit. Rev. Eukaryot. Gene Expr. 9 (3–4): 285–93. doi:10.1615/critreveukargeneexpr.v9.i3-4.130. PMID 10651245.
• Segura-Totten M, Wilson KL (2004). "BAF: roles in chromatin, nuclear structure and retrovirus integration". Trends Cell Biol. 14 (5): 261–6. doi:10.1016/j.tcb.2004.03.004. PMID 15130582.
• Van Maele B, Debyser Z (2005). "HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins". AIDS Reviews. 7 (1): 26–43. PMID 15875659.
• Van Maele B, Busschots K, Vandekerckhove L, et al. (2006). "Cellular co-factors of HIV-1 integration". Trends Biochem. Sci. 31 (2): 98–105. doi:10.1016/j.tibs.2005.12.002. PMID 16403635.
• Lee MS, Craigie R (1994). "Protection of retroviral DNA from autointegration: involvement of a cellular factor". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9823–7. Bibcode:1994PNAS...91.9823L. doi:10.1073/pnas.91.21.9823. PMC 44909. PMID 7937898.
• Dear PH, Bankier AT, Piper MB (1998). "A high-resolution metric HAPPY map of human chromosome 14". Genomics. 48 (2): 232–41. doi:10.1006/geno.1997.5140. PMID 9521877.
• Lynch RA, Piper M, Bankier A, et al. (1999). "Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma". Genomics. 52 (1): 17–26. doi:10.1006/geno.1998.5406. PMID 9740667.
• Cai M, Huang Y, Zheng R, et al. (1998). "Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration". Nat. Struct. Biol. 5 (10): 903–9. doi:10.1038/2345. PMID 9783751. S2CID 857675.
• Furukawa K (1999). "LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction". J. Cell Sci. 112 (15): 2485–92. doi:10.1242/jcs.112.15.2485. PMID 10393804.
• Zheng R, Ghirlando R, Lee MS, et al. (2000). "Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8997–9002. Bibcode:2000PNAS...97.8997Z. doi:10.1073/pnas.150240197. PMC 16810. PMID 10908652.
• Umland TC, Wei SQ, Craigie R, Davies DR (2000). "Structural basis of DNA bridging by barrier-to-autointegration factor". Biochemistry. 39 (31): 9130–8. doi:10.1021/bi000572w. PMID 10924106.
• Harris D, Engelman A (2001). "Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro". J. Biol. Chem. 275 (50): 39671–7. doi:10.1074/jbc.M002626200. PMID 11005805.
• Lee KK, Haraguchi T, Lee RS, et al. (2002). "Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF". J. Cell Sci. 114 (Pt 24): 4567–73. doi:10.1242/jcs.114.24.4567. PMID 11792821.
• Haraguchi T, Koujin T, Segura-Totten M, et al. (2002). "BAF is required for emerin assembly into the reforming nuclear envelope". J. Cell Sci. 114 (Pt 24): 4575–85. doi:10.1242/jcs.114.24.4575. PMID 11792822.
• Segura-Totten M, Kowalski AK, Craigie R, Wilson KL (2002). "Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly". J. Cell Biol. 158 (3): 475–85. doi:10.1083/jcb.200202019. PMC 2173821. PMID 12163470.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Holaska JM, Lee KK, Kowalski AK, Wilson KL (2003). "Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro". J. Biol. Chem. 278 (9): 6969–75. doi:10.1074/jbc.M208811200. PMID 12493765.
• Lin CW, Engelman A (2003). "The Barrier-to-Autointegration Factor Is a Component of Functional Human Immunodeficiency Virus Type 1 Preintegration Complexes". J. Virol. 77 (8): 5030–6. doi:10.1128/JVI.77.8.5030-5036.2003. PMC 152146. PMID 12663813.

External links

• Human BANF1 genome location and BANF1 gene details page in the UCSC Genome Browser.