Yoda1

Yoda1
Names
	Preferred IUPAC name 2-(5-{[(2,6-Dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)pyrazine
Identifiers
CAS Number	448947-81-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:194079;
PubChem CID	2746822;
UNII	TW6GF9RW6S ;
	SMILES ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1;
Properties
Chemical formula	C13H8Cl2N4S2
Molar mass	355.27 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Yoda1 is a chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1. This protein is involved in regulation of blood pressure and red blood cell volume, and Yoda1 is used in scientific research in these areas.^[1]^[2]^[3]^[4]^[5]

Piezo1 channels repress group 2 innate lymphoid cell (ILC2)–driven type 2 inflammation in the lungs. Piezo1 agonist Yoda1 reduces ILC2-driven lung inflammation and attenuates the development of bronchial hyperresponsiveness. Piezo1 activation with Yoda1 treatment could become a novel therapeutic approach for the treatment of ILC2-driven allergic asthma.^[6]

References[edit]

^ Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E.; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin; Tully, David C.; Engels, Ingo H.; Petrassi, H. Michael; Schumacher, Andrew M.; Montal, Mauricio; Bandell, Michael; Patapoutian, Ardem (2015). "Chemical activation of the mechanotransduction channel Piezo1". eLife. 4: e07369. doi:10.7554/eLife.07369. PMC 4456433. PMID 26001275. S2CID 2652667.
^ Cahalan, Stuart M.; Lukacs, Viktor; Ranade, Sanjeev S.; Chien, Shu; Bandell, Michael; Patapoutian, Ardem (2015). "Piezo1 links mechanical forces to red blood cell volume". eLife. 4: e07370. doi:10.7554/eLife.07370. PMC 4456639. PMID 26001274. S2CID 15018525.
^ Wang, ShengPeng; Chennupati, Ramesh; Kaur, Harmandeep; Iring, Andras; Wettschureck, Nina; Offermanns, Stefan (2016). "Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release". Journal of Clinical Investigation. 126 (12): 4527–4536. doi:10.1172/JCI87343. PMC 5127677. PMID 27797339. S2CID 38263363.
^ Rapetti-Mauss, Raphaël; Picard, Véronique; Guitton, Corinne; Ghazal, Khaldoun; Proulle, Valérie; Badens, Catherine; Soriani, Olivier; Garçon, Loïc; Guizouarn, Hélène (2017). "Red blood cell Gardos channel (KCNN4): The essential determinant of erythrocyte dehydration in hereditary xerocytosis". Haematologica. 102 (10): e415–e418. doi:10.3324/haematol.2017.171389. PMC 5622875. PMID 28619848. S2CID 31756119.
^ Gnanasambandam, R.; Gottlieb, P. A.; Sachs, F. (2017). "The Kinetics and the Permeation Properties of Piezo Channels". In Gottlieb, Philip A. (ed.). Piezo Channels. Current Topics in Membranes. Vol. 79. Academic Press. pp. 275–307. doi:10.1016/bs.ctm.2016.11.004. ISBN 978-0-12-809389-4. PMID 28728821. S2CID 3743286.
^ Hurrell, B. P., Shen, S., Li, X., Sakano, Y., Kazemi, M. H., Quach, C., ... & Akbari, O. (2024). "Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity". Journal of Experimental Medicine, 221(5), e20231835. PMID 38530239 PMC 10965393 (available on 2024-09-26) doi:10.1084/jem.20231835

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[1] Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E.; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin; Tully, David C.; Engels, Ingo H.; Petrassi, H. Michael; Schumacher, Andrew M.; Montal, Mauricio; Bandell, Michael; Patapoutian, Ardem (2015). "Chemical activation of the mechanotransduction channel Piezo1". eLife. 4: e07369. doi:10.7554/eLife.07369. PMC 4456433. PMID 26001275. S2CID 2652667.

[2] Cahalan, Stuart M.; Lukacs, Viktor; Ranade, Sanjeev S.; Chien, Shu; Bandell, Michael; Patapoutian, Ardem (2015). "Piezo1 links mechanical forces to red blood cell volume". eLife. 4: e07370. doi:10.7554/eLife.07370. PMC 4456639. PMID 26001274. S2CID 15018525.

[3] Wang, ShengPeng; Chennupati, Ramesh; Kaur, Harmandeep; Iring, Andras; Wettschureck, Nina; Offermanns, Stefan (2016). "Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release". Journal of Clinical Investigation. 126 (12): 4527–4536. doi:10.1172/JCI87343. PMC 5127677. PMID 27797339. S2CID 38263363.

[4] Rapetti-Mauss, Raphaël; Picard, Véronique; Guitton, Corinne; Ghazal, Khaldoun; Proulle, Valérie; Badens, Catherine; Soriani, Olivier; Garçon, Loïc; Guizouarn, Hélène (2017). "Red blood cell Gardos channel (KCNN4): The essential determinant of erythrocyte dehydration in hereditary xerocytosis". Haematologica. 102 (10): e415–e418. doi:10.3324/haematol.2017.171389. PMC 5622875. PMID 28619848. S2CID 31756119.

[5] Gnanasambandam, R.; Gottlieb, P. A.; Sachs, F. (2017). "The Kinetics and the Permeation Properties of Piezo Channels". In Gottlieb, Philip A. (ed.). Piezo Channels. Current Topics in Membranes. Vol. 79. Academic Press. pp. 275–307. doi:10.1016/bs.ctm.2016.11.004. ISBN 978-0-12-809389-4. PMID 28728821. S2CID 3743286.

[6] Hurrell, B. P., Shen, S., Li, X., Sakano, Y., Kazemi, M. H., Quach, C., ... & Akbari, O. (2024). "Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity". Journal of Experimental Medicine, 221(5), e20231835. PMID 38530239 PMC 10965393 (available on 2024-09-26) doi:10.1084/jem.20231835

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