VN1R1

VN1R1
Identifiers
Aliases	VN1R1, V1RL1, VNR19I1, ZVNH1, ZVNR1, vomeronasal 1 receptor 1
External IDs	OMIM: 605234 HomoloGene: 110801 GeneCards: VN1R1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	57,457,140 bp
RNA expression pattern
	Top expressed in
	cerebellar cortex; ; cerebellar hemisphere; ; skeletal muscle tissue; ; superior frontal gyrus; ; gastrocnemius muscle; ; ganglionic eminence; ; pituitary gland; ; Brodmann area 9; ; anterior pituitary; ; left ventricle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; pheromone receptor activity; signal transducer activity; pheromone binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; response to pheromone; signal transduction; sensory perception of chemical stimulus; biological process;
	Sources:Amigo / QuickGO
Orthologs
	57191
	n/a
	ENSG00000178201
	n/a
	Q9GZP7
	n/a
	NM_020633
	n/a
	NP_065684
	n/a
	Wikidata
View/Edit Human

Vomeronasal type-1 receptor 1 is a protein that in humans is encoded by the VN1R1 gene.^[3]^[4]

Function[edit]

Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.^[4]

Ligands[edit]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178201 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rodriguez I, Greer CA, Mok MY, Mombaerts P (September 2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nature Genetics. 26 (1): 18–9. doi:10.1038/79124. PMID 10973240. S2CID 21063460.
^ ^a ^b "Entrez Gene: VN1R1 vomeronasal 1 receptor 1".
^ Shirokova E, Raguse JD, Meyerhof W, Krautwurst D. The human vomeronasal type-1 receptor family--detection of volatiles and cAMP signaling in HeLa/Olf cells. FASEB J. 2008 May;22(5):1416-25. doi:10.1096/fj.07-9233com PMID 18096815
^ Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H (June 2015). "The smelling of Hedione results in sex-differentiated human brain activity". NeuroImage. 113: 365–73. doi:10.1016/j.neuroimage.2015.03.029. PMID 25797832. S2CID 6526522.
^ Ouyang J, Bae H, Jordi S, Dao QM, Dossenbach S, Dehn S, Lingnau JB, Kanta De C, Kraft P, List B (Feb 2021). "The Smelling Principle of Vetiver Oil, Unveiled by Chemical Synthesis". Angew Chem Int Ed Engl. 60 (11): 5666–5672. doi:10.1002/anie.202014609. PMC 7986879. PMID 33315304. (reference 30)

Further reading[edit]

Giorgi D, Friedman C, Trask BJ, Rouquier S (December 2000). "Characterization of nonfunctional V1R-like pheromone receptor sequences in human". Genome Research. 10 (12): 1979–85. doi:10.1101/gr.10.12.1979. PMC 313059. PMID 11116092.
Pantages E, Dulac C (December 2000). "A novel family of candidate pheromone receptors in mammals". Neuron. 28 (3): 835–45. doi:10.1016/S0896-6273(00)00157-4. PMID 11163270. S2CID 15023062.
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Zhang J, Webb DM (July 2003). "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8337–41. Bibcode:2003PNAS..100.8337Z. doi:10.1073/pnas.1331721100. PMC 166230. PMID 12826614.
Mitropoulos C, Papachatzopoulou A, Menounos PG, Kolonelou C, Pappa M, Bertolis G, Gerou S, Patrinos GP (2007). "Association study of human VN1R1 pheromone receptor gene alleles and gender". Genetic Testing. 11 (2): 128–32. doi:10.1089/gte.2006.0516. PMID 17627382.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178201 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10973240-3] Rodriguez I, Greer CA, Mok MY, Mombaerts P (September 2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nature Genetics. 26 (1): 18–9. doi:10.1038/79124. PMID 10973240. S2CID 21063460.

[entrez-4] "Entrez Gene: VN1R1 vomeronasal 1 receptor 1".

[5] Shirokova E, Raguse JD, Meyerhof W, Krautwurst D. The human vomeronasal type-1 receptor family--detection of volatiles and cAMP signaling in HeLa/Olf cells. FASEB J. 2008 May;22(5):1416-25. doi:10.1096/fj.07-9233com PMID 18096815

[Wallrabenstein_2015-6] Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H (June 2015). "The smelling of Hedione results in sex-differentiated human brain activity". NeuroImage. 113: 365–73. doi:10.1016/j.neuroimage.2015.03.029. PMID 25797832. S2CID 6526522.

[Ouyang_2021-7] Ouyang J, Bae H, Jordi S, Dao QM, Dossenbach S, Dehn S, Lingnau JB, Kanta De C, Kraft P, List B (Feb 2021). "The Smelling Principle of Vetiver Oil, Unveiled by Chemical Synthesis". Angew Chem Int Ed Engl. 60 (11): 5666–5672. doi:10.1002/anie.202014609. PMC 7986879. PMID 33315304. (reference 30)

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