User:Mr. Ibrahem/Suramin

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Mr. Ibrahem/Suramin
Clinical data
Trade namesAntrypol, 309 Fourneau, Bayer 205, others
AHFS/Drugs.comDrugs.com archive
Routes of
administration		By injection only
Legal status
Legal status
  • US: Not FDA approved
Identifiers
  • 8,8'-{Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}di(1,3,5-naphthalenetrisulfonic acid)
Chemical and physical data
FormulaC51H40N6O23S6
Molar mass1297.26 g·mol−1
3D model (JSmol)
  • O=C(Nc1cc(ccc1C)C(=O)Nc3c2c(cc(cc2c(cc3)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c8cccc(NC(=O)Nc7cc(C(=O)Nc6cc(C(=O)Nc5c4c(cc(cc4c(cc5)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)ccc6C)ccc7)c8
  • InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) checkY
  • Key:FIAFUQMPZJWCLV-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Suramin is a medication used to treat African sleeping sickness and river blindness.[1][3] It is the treatment of choice for sleeping sickness without central nervous system involvement.[4] It is given by injection into a vein.[5]

Suramin causes a fair number of side effects.[5] Common side effects include nausea, vomiting, diarrhea, headache, skin tingling, and weakness.[3] Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur.[3] Severe side effects may include low blood pressure, decreased level of consciousness, kidney problems, and low blood cell levels.[5] It is unclear if it is safe when breastfeeding.[3]

Suramin was made at least as early as 1916.[6] It is on the World Health Organization's List of Essential Medicines.[7] In the United States it can be acquired from the Centers for Disease Control (CDC).[4] The cost of the medication for a course of treatment is about US$27.[8] In regions of the world where the disease is common suramin is provided for free by the World Health Organization (WHO).[9]

References[edit]

  1. ^ a b "Suramin Injection Advanced Patient Information". Drugs.com. 3 January 2020. Archived from the original on 8 November 2016. Retrieved 11 January 2020.
  2. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 September 2020. Retrieved 4 September 2020.
  3. ^ a b c d "Micromedex Detailed Drug Information for the Consumer: Suramin (Injection route)". PubMed Health. 1 November 2016. Archived from the original on 8 September 2017.
  4. ^ a b "Our Formulary Infectious Diseases Laboratories CDC". www.cdc.gov. 22 September 2016. Archived from the original on 16 December 2016. Retrieved 30 November 2016.
  5. ^ a b c Zuckerman, Dr Jane N. (2002). Principles and Practice of Travel Medicine. John Wiley & Sons. p. 113. ISBN 9780471490791. Archived from the original on 2016-11-30.
  6. ^ Mehlhorn, Heinz (2008). Encyclopedia of Parasitology: A-M. Springer Science & Business Media. p. 475. ISBN 9783540489948. Archived from the original on 2016-11-30.
  7. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  8. ^ Dumas, Michel; Bouteille, Bernard; Buguet, Alain (2013). Progress in Human African Trypanosomiasis, Sleeping Sickness. Springer Science & Business Media. p. 256. ISBN 9782817808574. Archived from the original on 2016-11-30.
  9. ^ "Trypanosomiasis, human African (sleeping sickness)". World Health Organization. February 2016. Archived from the original on 4 December 2016. Retrieved 7 December 2016.
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