User:Mr. Ibrahem/Propafenone

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Mr. Ibrahem/Propafenone
Clinical data
Pronunciation/proʊˈpæfɪnoʊn/ proh-PAF-i-nohn
Trade namesRythmol, Rytmonorm, others
AHFS/Drugs.comMonograph
MedlinePlusa698002
License data
Routes of
administration		By mouth
Drug classClass 1c anti-arrhythmic medication[1]
Legal status
Legal status
Pharmacokinetic data
Protein binding97%
Elimination half-life2–10 hours
Identifiers
  • 1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
Chemical and physical data
FormulaC21H27NO3
Molar mass341.451 g·mol−1
3D model (JSmol)
  • O=C(c1ccccc1OCC(O)CNCCC)CCc2ccccc2
  • InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3 checkY
  • Key:JWHAUXFOSRPERK-UHFFFAOYSA-N checkY
  (verify)

Propafenone, sold under the brand name Rythmol among others, is a medication used to treat supraventricular and ventricular tachyarrhythmias.[1] Long term use is generally not recommended.[3] It is taken by mouth.[1]

Common side effects include nausea, dizziness, headache, blurry vision, shortness of breath, and liver problems.[1] Other side effects may include heart failure, other arrhythmias, and low white blood cells.[1] Use is not recommended in people with structural heart disease or ischemic heart disease.[1] It is a class 1c anti-arrhythmic medication.[1]

Propafenone was approved for medical use in the United States in 1989.[1] It is available as a generic medication.[4] In the United Kingdom a typical dose costs the NHS about £7 a month.[4] In the United States this amount is 15 USD per month.[5] A long acting formulation is also available.[1]

References[edit]

  1. ^ a b c d e f g h i j k "Propafenone Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 29 October 2021.
  2. ^ "Propafenone Use During Pregnancy". Drugs.com. 13 November 2018. Archived from the original on 7 February 2020. Retrieved 7 February 2020.
  3. ^ Bersten, Andrew D.; Handy, Jonathan (15 August 2018). Oh's Intensive Care Manual E-Book. Elsevier Health Sciences. p. 271. ISBN 978-0-7020-7606-0. Archived from the original on 30 October 2021. Retrieved 29 October 2021.
  4. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 112. ISBN 978-0857114105.
  5. ^ "Propafenone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 29 October 2021.
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