User:Mr. Ibrahem/Glycopyrronium

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Mr. Ibrahem/Glycopyrronium
Clinical data
Trade namesRobinul, Cuvposa, Seebri, others
Other namesGlycopyrrolate, glycopyrronium bromide, glycopyrronium tosylate
AHFS/Drugs.comSystemic: Monograph
Topical: Monograph
License data
Pregnancy
category
  • AU: B2
Routes of
administration		By mouth, intravenous, inhaled, topical
Drug classAntimuscarinic[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Identifiers
  • 3-[2-Cyclopentyl(hydroxy)phenylacetoxy]-1,1-dimethylpyrrolidinium bromide
Chemical and physical data
FormulaC19H28BrNO3
Molar mass398.341 g·mol−1
3D model (JSmol)
  • C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.[Br-]
  • InChI=1S/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1
  • Key:VPNYRYCIDCJBOM-UHFFFAOYSA-M

Glycopyrronium, also known as glycopyrrolate, is a medication used to treat COPD, excessive saliva, and excessive sweating.[1][2] It may be taken by mouth, by injection, applied to the skin, or inhaled.[1][2] Effects may last for up to 12 hours.[1] It is also available in combination with a long-acting beta-adrenoceptor agonist (LABA) and inhaled steroid.[2]

Common side effects include dry mouth, urinary retention, blurry vision, large pupils, headache, confusion, sleepiness, and constipation.[1] Other side effects may include allergic reactions and bronchospasm.[1] Safety in pregnancy is unclear.[1] It is an antimuscarinic.[1] It does not generally cross the blood–brain barrier.[1]

Glycopyrronium was approved for medical use in the United States in 1961.[1] It is on the World Health Organization's List of Essential Medicines as an alternative to tiotropium.[3] In the United Kingdom a month of inhaled medication costs the NHS about £28 as of 2021.[2] In the United States the tablets are inexpensive.[4]

References[edit]

  1. ^ a b c d e f g h i j k l "Glycopyrrolate Monograph for Professionals". Drugs.com. Archived from the original on 16 July 2021. Retrieved 3 December 2021.
  2. ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 262. ISBN 978-0857114105.
  3. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  4. ^ "Glycopyrrolate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 December 2021.
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