User:Mr. Ibrahem/Fosinopril

Mr. Ibrahem/Fosinopril
Clinical data
Trade names	Monopril
Other names	Fosinopril sodium
AHFS/Drugs.com	Monograph
MedlinePlus	a692020
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth
Drug class	ACE inhibitor
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	~36%
Protein binding	87% (fosinoprilat)
Metabolism	Liver, GIT mucosa (to fosinoprilat)
Elimination half-life	12 hours (fosinoprilat)
Excretion	Kidney
Identifiers
	IUPAC name (2S,4S)-4-cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid;
Chemical and physical data
Formula	C30H46NO7P
Molar mass	563.672 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(CP(=O)(CCCCc1ccccc1)OC(OC(=O)CC)C(C)C)N2C[C@@H](C[C@H]2C(O)=O)C3CCCCC3;
	InChI InChI=1S/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30?,39-/m1/s1 ; Key:BIDNLKIUORFRQP-YYTCENNOSA-N ;
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Fosinopril, sold under the brand name Monopril among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.^[2]^[1] It is one of a number of first line agents for high blood pressure.^[1] It is taken by mouth.^[2]

Common side effects include cough, nausea, and dizziness.^[1] Other side effects may include low blood pressure, liver problems, allergic reactions, high potassium, and kidney problems.^[1] Use during pregnancy may harm the baby.^[1] It is a angiotensin converting enzyme (ACE) inhibitor.^[1]

Fosinopril was patented in 1980 and approved for medical use in 1991.^[3] It is available as a generic medication.^[2] In the United Kingdom 4 weeks of 20 mg cost the NHS about £2 as of 2021.^[2] This amount in the United States costs about 10 USD.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Fosinopril Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 13 December 2021.
^ ^a ^b ^c ^d ^e ^f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 183. ISBN 978-0857114105.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495. Archived from the original on 2020-10-18. Retrieved 2021-10-15.
^ "Fosinopril Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 December 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Fosinopril Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 13 December 2021.

[BNF81-2] ^ ^a ^b ^c ^d ^e ^f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 183. ISBN 978-0857114105.

[Fis2006-3] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495. Archived from the original on 2020-10-18. Retrieved 2021-10-15.

[4] "Fosinopril Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 December 2021.

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