User:Mr. Ibrahem/Dronedarone

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Mr. Ibrahem/Dronedarone
Clinical data
Trade namesMultaq
Other namesDronedarone hydrochloride, SR33589
AHFS/Drugs.comMonograph
MedlinePlusa609034
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
Drug classClass III antiarrhythmic[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only[2]
  • EU: Rx-only
Pharmacokinetic data
Bioavailability15% (with a high-fat meal)[2]
Protein binding>98%
MetabolismExtensive liver (mainly by CYP3A)
Elimination half-life13–19 hours
ExcretionFeces (84%), urine (~6%)
Identifiers
  • N-(2-Butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide
Chemical and physical data
FormulaC31H44N2O5S
Molar mass556.76 g·mol−1
3D model (JSmol)
  • O=S(=O)(Nc3cc1c(oc(c1C(=O)c2ccc(OCCCN(CCCC)CCCC)cc2)CCCC)cc3)C
  • InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3 checkY
  • Key:ZQTNQVWKHCQYLQ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Dronedarone, sold under the brand name Multaq, is a medication used to keep people who have a history of atrial fibrillation in sinus rhythm.[2] While it may not work as well as amiodarone, it may be safer.[1] It should not be used in people who are always in atrial fibrillation.[1] It is taken by mouth.[2]

Common side effects include diarrhea, nausea, abdominal pain, and feeling weak.[2] Other side effects may include liver problems, low potassium, low magnesium, and kidney problems.[2] It should not be used in heart failure.[3] Use in pregnancy may harm the baby.[2] It is primarily a class III antiarrhythmic.[1]

Dronedarone was approved for medical use in the United States and Europe in 2009.[2][3] It is available as a generic medication.[4] In the United States it costs about 680 USD per month as of 2021.[5] This amount in the United Kingdom costs about £67.[4]

References[edit]

  1. ^ a b c d "Dronedarone Monograph for Professionals". Drugs.com. Archived from the original on 5 October 2021. Retrieved 27 December 2021.
  2. ^ a b c d e f g h i j k "Multaq- dronedarone tablet, film coated". DailyMed. 15 October 2020. Archived from the original on 14 September 2015. Retrieved 18 November 2020.
  3. ^ a b "Multaq". Archived from the original on 28 December 2021. Retrieved 27 December 2021.
  4. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 115. ISBN 978-0857114105.
  5. ^ "Dronedarone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 27 December 2021.
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