User:Mr. Ibrahem/Bosentan

Mr. Ibrahem/Bosentan
Clinical data
Trade names	Tracleer, Stayveer
AHFS/Drugs.com	Monograph
MedlinePlus	a605001
License data	EU EMA: by INN; US DailyMed: Bosentan;
Pregnancy; category	AU: X (High risk); X;
Routes of; administration	By mouth
Drug class	Endothelin receptor antagonist
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	50%
Protein binding	>98%
Metabolism	Liver
Elimination half-life	5 hours
Identifiers
	IUPAC name 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide;
Chemical and physical data
Formula	C27H29N5O6S
Molar mass	551.62 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2c(c(nc(n2)c3ncccn3)OCCO)Oc4ccccc4OC;
	InChI InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32) ; Key:GJPICJJJRGTNOD-UHFFFAOYSA-N ;
	(what is this?) (verify)

Bosentan, sold under the brand name Tracleer among others, is a medication used to treat pulmonary artery hypertension (PAH) and systemic sclerosis.^[1]^[4] It is taken by mouth.^[4] It may be used in those over the age of 2.^[1]

Common side effects include respiratory tract infection, low red blood cells, and fever.^[1] Other side effects may include swelling, liver probelms, and pulmonary veno-occlusive disease.^[1] Use in pregnancy may harm the baby.^[1] It is a endothelin receptor antagonist.^[1]

Bosentan was approved for medical use in the United States in 2001 and Europe in 2022.^[1]^[3] It is avaliable as a generic medication.^[4] In the United Kingdom 4 weeks of treatment costs about £110 as of 2021.^[4] This amount in the United States is about 1,100 USD.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Tracleer- bosentan tablet, film coated Tracleer- bosentan tablet, soluble". DailyMed. 15 June 2020. Archived from the original on 12 May 2021. Retrieved 15 October 2020.
^ "Tracleer (bosentan) 62.5 mg and 125mg film-coated tablets". UK Electronic Medicines Compendium. May 2017. Archived from the original on 27 July 2020. Retrieved 6 August 2017.
^ ^a ^b "Tracleer EPAR". European Medicines Agency (EMA). Archived from the original on 5 November 2021. Retrieved 16 October 2020.
^ ^a ^b ^c ^d ^e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 198. ISBN 978-0857114105.
^ "Bosentan Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 11 January 2022.

[PI2022-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Tracleer- bosentan tablet, film coated Tracleer- bosentan tablet, soluble". DailyMed. 15 June 2020. Archived from the original on 12 May 2021. Retrieved 15 October 2020.

[UKlabel2017-2] "Tracleer (bosentan) 62.5 mg and 125mg film-coated tablets". UK Electronic Medicines Compendium. May 2017. Archived from the original on 27 July 2020. Retrieved 6 August 2017.

[EPAR2022-3] "Tracleer EPAR". European Medicines Agency (EMA). Archived from the original on 5 November 2021. Retrieved 16 October 2020.

[BNF81-4] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 198. ISBN 978-0857114105.

[5] "Bosentan Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 11 January 2022.

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