User:Mr. Ibrahem/Betaxolol

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Mr. Ibrahem/Betaxolol
Clinical data
Pronunciationbe tax' oh lol[1]
Trade namesKerlone[1]
AHFS/Drugs.comSystemic: Monograph
Eye: Monograph
MedlinePlusa609023
Pregnancy
category
  • AU: C
Routes of
administration		By mouth, eye drop
Drug classCardioselective beta blocker[1]
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability89%
MetabolismLiver
Elimination half-life14–22 hours
ExcretionKidney (20%)
Identifiers
  • (RS)-1-{4-[2-(cyclopropylmethoxy)ethyl]-
    phenoxy}-3-(isopropylamino)propan-2-ol
Chemical and physical data
FormulaC18H29NO3
Molar mass307.434 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • O(CCc1ccc(OCC(O)CNC(C)C)cc1)CC2CC2
  • InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3 checkY
  • Key:NWIUTZDMDHAVTP-UHFFFAOYSA-N checkY
  (verify)

Betaxolol, sold under the brand name Kerlone among others, is a medication used to treat glaucoma and high blood pressure.[1] It reduces eye pressure by about 30%.[3] It is not a first line treatment for blood pressure.[4] It is take by mouth or used as an eye drop.[1]

Common side effects by mouth include slow heart rate, low blood pressure, tiredness, dizziness, depression, trouble sleeping, memory loss, and sexual dysfunction.[1] At high doses it can induce bronchospasm.[1] Common side effects from the eye drops include eye irritation.[2] Safety in pregnancy is unclear.[4] It is a selective beta1 receptor blocker.[1] As an eye drop it is thought to work by reducing the production of aqueous humor within the eye.[3]

Betaxolol was patented in 1975 and approved for medical use in 1983.[5] It is available as a generic medication.[1] In the United Kingdom a 5 ml bottle of eye drops costs the NHS about £2 as of 2021.[2] In the United States this amount costs about 21 USD.[6]

References[edit]

  1. ^ a b c d e f g h i j k l "Betaxolol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 10 January 2022.
  2. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1224. ISBN 978-0857114105.
  3. ^ a b "Betaxolol (EENT) Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 10 January 2022.
  4. ^ a b "Betaxolol (Systemic) Monograph for Professionals". Drugs.com. Archived from the original on 6 August 2021. Retrieved 10 January 2022.
  5. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495. Archived from the original on 2017-09-08. Retrieved 2021-03-21.
  6. ^ "Betaxolol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 October 2016. Retrieved 10 January 2022.
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