Talk:Solid lipid nanoparticle

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The diagrams in the article are incorrect[edit]

The articles published by Cullis et al. indicate that the lipid nanoparticles currently in common use have an outer layer of PEGylated lipids wrapped around inverse micelles on the inside (heads in, tails out) which encapsulate mRNA payloads. The diagrams in the article do not correctly depict this. Precision NanoSystems depicts LNPs correctly on the front page of their Web site. --Coolcaesar (talk) 18:20, 12 March 2021 (UTC)[reply]

The focus of the page is incorrect[edit]

Following a litterature review, it appears to me that Solid Lipid Nanoparticle (or SLN) actually are a sub-category of the Lipid-based nanoparticle category (or lipid-based nanoparticle carrier), which contains the Lipid Nanoparticles (LNP) as another sub category.

Therefore here starting the article on "Solid lipid nanoparticle" by defining "lipid nanoparticles (LNPs)" is both off topic (2 different things) + the definition of LNP is wrong.

Indeed the definition given "nanoparticles composed of lipids", corresponds to the "lipid based nanoparticle" definition, neither SLN or LNP, while "Lipid nanoparticles" corresponds to the subcategory of "lipid based nanoparticles encapsulating various types of nucleic acids (mRNA, siRNA...) ". It might be interesting to open another specific page on the "lipid nanoparticle (LNP)" itself. Robin11111111 (talk) 13:31, 19 January 2023 (UTC)[reply]