Talk:Progressive rubella panencephalitis

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PRP after postnatal rubella infection[edit]

Progressive rubella panencephalitis has also been described after childhood rubella, although it seems more common in congenital rubella patients.

See https://link.springer.com/chapter/10.1007/978-3-662-02568-0_36, for example.

I have found no information whether it can occur after adult rubella, however. This is probably because PRP is generally very rare, and should it occur in older adults (as would be the case after an adult infection) it may be hard to distinguish from various forms of dementia or other viral encephalitis like that caused by JC virus.

The similar condition SSPE is known to occur after adult measles infection, but much rarer than SSPE following childhood infection. If PRP incidence is analogous it would be possible but extremely rare to occur after adult rubella. Together with the fact that PRP is altogether rarer than SSPE, that would explain the lack of case reports.

There is generally a lack of case reports of PRP from the 2000s on. This probably reflects increasing vaccination coverage and consequent decrease of rubella infections, CRS and PRP. Just by the way. --2003:E7:7732:BF05:1C46:3428:AC13:557 (talk) 01:05, 28 March 2020 (UTC)[reply]