Talk:Lapatinib

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Lapatinib.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Pharmacology Mid‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Brands

	This article is within the scope of WikiProject Brands, a collaborative effort to improve the coverage of brands on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.BrandsWikipedia:WikiProject BrandsTemplate:WikiProject BrandsBrands articles
???	This article has not yet received a rating on the project's importance scale.

Medicine Mid‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

The[edit]

"The exact site of binding has currently not been confirmed (EGFR and ErbB2 have a number of intracellular phosphorylation sites)." -- this should probably be removed, at least for EGFR, since there's a crystal structure of Lapatinib bound to the ATP binding site from 2004: pdb code 1XKK.

Lapatinib is well known as an ATP-competitive kinase inhibitor (that was determined well before the crystal structure being solved). The comment has been removed. 05:52, 18 December 2007 (UTC)btavshan

Its identity as a kinase inhibitor is explicated in the third paragraph, if that wasn't obvious enough from the name. Could you point to when/where/what was actually removed? Otherwise, I can't tell if any information is missing that could go in there. Someguy1221 (talk) 05:57, 18 December 2007 (UTC)[reply]

Lapatinib[edit]

Lapatinib is a yellow solid having a solubility of 0.007 mg/ml in water at 25 degrees centigrade. The drug (Lapatinib Ditosylate) marketed by GSK, has been found to be effective in the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have recieved prior therapy including an anthracycline, a taxane and trastuzumab. It is prescribed in combination with capacetabine as a ditosylate salt.

News re combo trial for HER2 breast cancer[edit]

Anti-HER2 Combo Shrunk Breast Tumors in Under 2 Weeks "A quarter of women with HER2-positive breast cancer treated with a combination of lapatinib plus trastuzumab prior to surgery had significant tumor shrinkage within 11 days." - Rod57 (talk) 03:00, 12 March 2016 (UTC)[reply]

as ditosylate[edit]

Most of the article seems to be talking about lapatinib ditosylate but the molecular structure and molecular formula are of the bare lapatinib. Presumably, in principle, different forms of lapatinib could exist and be licenced so we should clarify which content applies to just the ditosylate form. We could note where on lapatinib the two? tosylates are attached, and say under what conditions (pH ?) they dissociate. eg during oral administration and absorption where/do the tosylates detatch ? - Rod57 (talk) 14:05, 13 July 2017 (UTC)[reply]

External links modified[edit]

Hello fellow Wikipedians,

I have just modified 3 external links on Lapatinib. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 18 January 2022).

If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 02:02, 17 December 2017 (UTC)[reply]