Talk:Klebsiella pneumoniae

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1. anybody knows which antibiotic is used to treat klebsiella?
2. what does klebsiella pneumonia secrete?? - unsigned

1. Any of a number of antibiotics have been used, but typically Klebsiella is treated with a third-generation cephalosporin, a carbapenem, an aminoglycoside or a quinolone, or some combination of them.

2. I'm not sure what you're asking, but you might be alluding to the fact that multi-drug resistant strains exist that produce an extended-spectrum beta-lactamase (ESBL). Or you may be asking if Klebsiellae are lactose-fermenting, urease-positive and indole-negative organisms, which they are. - Nunh-huh 06:40, 23 July 2006 (UTC)

K. oxytoca are indole-positive. - Emt147 ^Burninate! 04:54, 11 October 2006 (UTC)

2 unacylated form of pullulanase

Other lifestyles

This page is heavily biased towards the human-related strains of K. pneumoniae, but many strains are found on plant matter, in soil and in water. It would be god to give the article more balance by including information on non-human colonizing K. pneumoniae. Maonao (talk) 04:12, 11 April 2014 (UTC)

Resistance

This makes no sense: Many strains have acquired an extended-spectrum beta-lactamase with additional resistance to carbenicillin, ampicillin, quinolones, and increasingly to ceftazidime. The bacteria remain largely susceptible to aminoglycosides and cephalosporins.

Either it's resistant to ceftazidime or it's susceptible to cephalosporins. Which is it? - Emt147 ^Burninate! 08:23, 25 December 2006 (UTC)

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I hope someone will soon add the following info to the article.

A strain of kb found in a Swedish woman who had been treated in a hospital in India "was found to be indifferent to even our most powerful antibiotics."

  http://www.guardian.co.uk/science/2011/apr/07/antibiotic-resistance-bacteria  "In 2008 the rising waters [of drug-resistant pathogens] were finally lapping at our feet. An unusually hardy strain of Klebsiella pneumoniae was isolated from a 59-year-old Swedish patient who had been treated in a New Delhi, India, hospital. The bacterium was found to be indifferent to even our most powerful antibiotics. To make matters worse, the genes that gave it this superpower were found on a small ring of DNA that is easily traded between different species of bacteria.  NDM has now been found in 16 nations including UK [and US]. One strain is immune to all antibiotics..In a report published last year, the US Institute of Medicine described antimicrobial resistance as "a global public health and environmental catastrophe", while the WHO called the rise of NDM-1 a "doomsday scenario of a world without antibiotics". 

173.210.125.42 (talk) 17:57, 26 September 2011 (UTC)

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Studies should be done on the effects of anti-histamines and mast cell membrane stablizers.

Since lung inflammation is a large component in the disease process and since mast cells located in the lungs can release large amounts of histamine upon damage, it seems doctors should consider the use of both anti-histamines and mast cell stablizers like cromolyn to minimize the effects of infection. Inflammation itself can help spread infection and histamine also makes for leaky capillaries, inflammation, and constricted airways. The drug companies always want to focus in on using anti-inflammatory steroids which are more expensive than anti-histamines, require and Rx, and have side effects that promote more drug treatment. (Comment from pharmacist Richard D. Blythe). — Preceding unsigned comment added by 50.104.241.74 (talk) 03:27, 16 September 2012 (UTC)

Important?

"is a Gram-negative, non-motile, encapsulated, lactose fermenting, facultative anaerobic, rod shaped bacterium found in the normal flora of the mouth, skin, and intestines It is clinically the most important member of the Klebsiella genus of Enterobacteriaceae."

This sounds like it important to have in our mouth skin and intestines. can someone clarify this, please?165.212.189.187 (talk) 19:35, 24 January 2013 (UTC)

Citations for Mortality Rate

As I don't generally edit technical, medical articles (yet) I am posting citation information for mortality rates (tagged citation needed in article).

• Citation for mortality rates of infection with CRPK "Carbapenem-Resistant Klebsiella pneumoniae" at Center for Disease Dynamics and Economic Policy, the article that cites "Clinical outcomes of patients with KPC-producing Klebsiella pneumoniae following treatment with imipenem or meropenem" the two articles that the second article cites for mortality rates
• Bratu, S.; Landman, D.; Haag, R.; Recco, R.; Eramo, A.; Alam, M.; Quale, J. (2005). "Rapid Spread of Carbapenem-Resistant Klebsiella pneumoniae in New York City: A New Threat to Our Antibiotic Armamentarium". Archives of Internal Medicine. 165 (12): 1430–1435. doi:10.1001/archinte.165.12.1430. PMID 15983294.
• Woodford, N.; Tierno Jr, P. M.; Young, K.; Tysall, L.; Palepou, M. -F. I.; Ward, E.; Painter, R. E.; Suber, D. F.; Shungu, D.; Silver, L. L.; Inglima, K.; Kornblum, J.; Livermore, D. M. (2004). "Outbreak of Klebsiella pneumoniae Producing a New Carbapenem- Hydrolyzing Class A  -Lactamase, KPC-3, in a New York Medical Center". Antimicrobial Agents and Chemotherapy. 48 (12): 4793–4799. doi:10.1128/AAC.48.12.4793-4799.2004. PMC 529220. PMID 15561858. {{cite journal}}: no-break space character in |title= at position 83 (help)

- - MrBill3 (talk) 08:36, 15 July 2013 (UTC)

Resistant Strains

I can't find any evidence that all 26 antibiotics were used therapeutically in this patient, just that the resistance of an isolate from the patient was assayed by CDC. https://www.cdc.gov/mmwr/volumes/66/wr/mm6601a7.htm?s_cid=mm6601a7_e Ianmc (talk) 19:51, 19 January 2017 (UTC)

That is a fair point, but this specific The Daily Caller article seems to suggest, due to the wording used, that the 26 antibiotics were used on the woman for the express purpose of attempting to cure her, and not on some biopsy sample or what have you. ‘Super-Bug’ Resistant To EVERY Antibiotic In America Kills Woman ("Doctor’s tested 26 different antibiotics on the woman in vain before she died.") Perhaps The Daily Caller article writer was also confused about the CDC findings. Penskins (talk) 21:31, 19 January 2017 (UTC)

Lancet death toll data

My apologies about the clunky insertion of the AMR death toll data. I was looking for this sort of data in the article, and when I didn't find it, I emailed the CDC who referred me to that Lancet article. I know it's not cited correctly or in the right place, but I'm disabled and my hands are hurting quite a bit after adding transcribing that table; so I hope someone else can tidy things up or find the appropriate location for the table or properly incorporate that data into this article. Perhaps move the table and then refer to it in this article? Crimson30 (talk) 18:01, 23 December 2023 (UTC)