Talk:H19 (gene)

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Untitled[edit]

Why is there a part titled genome instability if it is not known whether or not this gene has a relation with it. It seems unnecessary. — Preceding unsigned comment added by 217.131.215.138 (talk) 09:28, 6 January 2013 (UTC)[reply]

suggested addition Hello you dear people who watch the non-translated RNA pages -- I was at the Sanger visit for the ABSW and heard of the interest in annotating these pages. Here's a reference for you that extends interest in H19 and its microRNA / IncRNA to osteoarthritis: J Mol Med (Berl). 2012 Apr 21. [Epub ahead of print] Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions. PMID: 22527881 Cheers!Celia Kozlowski (talk) 22:14, 30 April 2012 (UTC)[reply]

A short question: How can one make a statement of the amino acid level, if it's claimed, that there's no product of translation ? —Preceding unsigned comment added by 95.113.31.3 (talk) 17:48, 5 December 2009 (UTC)[reply]

Seems reasonable to me. The full quote is "Although the RNA sequence was highly conserved evolutionarily, at the amino acid level, there was a complete absence of conservation", the section is on evidence why researchers think this is a ncRNA and not a protein-coding gene. So if you take the H19 gene from many different species and translate the sequence (probably in all 3 frames) and compare these sequences you see none that show any significant level of evolutionary constraint. --Paul (talk) 21:01, 5 December 2009 (UTC)[reply]

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Reference 18[edit]

Dear all,

As landmark as reference 18 is, it seems to have been used rather generously for statements the original paper wouldn't actually support, for example, that reference 18 has anything to do with DNMT-null mice as mentioned in the IGF-2 section. I just thought I'd put this here as I'm not sure how many of the references here are actually correct.

Maybe the original author or someone with further knowledge can identify what the correct reference is for some of these statements (that I'm sure are correct, just inaccurately referenced) — Preceding unsigned comment added by TobyBrann (talk • contribs) 12:18, 31 January 2021 (UTC)[reply]