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The earliest illustration of tuberous sclerosis, with clusters of facial angiofibromas, displayed in Rayer's colour atlas of skin diseases published in 1835: "Traité des maladies de la peau".

Photo credit: Bibliothèque Interuniversitaire de Médecine - http://www.bium.univ-paris5.fr/histmed/medica/page?00584&p=82

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