Phageome
A phageome is a community of bacteriophages and their metagenomes localized in a particular environment, similar to a microbiome.[1][2] The term was first used in an article by Modi et al in 2013[3] and has continued to be used in scientific articles that relate to bacteriophages and their metagenomes. A bacteriophage, or phage for short, is a virus that has the ability to infect bacteria and archaea, and can replicate inside of them. Phageome is a subcategory of virome, which is all of the viruses that are associated with a host or environment.[4] Phages make up the majority of most viromes and are currently understood as being the most abundant organism.[5] Oftentimes scientists will look only at a phageome instead of a virome while conducting research.
In humans[edit]
Although bacteriophages do not have the capability to infect human cells, they are found in abundance in the human virome.[6]
The human gut phageome has recently become a topic of interest in the scientific community. The makeup of the gut phageome can be responsible for different gut related diseases such as IBD. The composition of phages that make up a healthy human gut phageome is currently debated, since different methods of research can lead to different results.[7]
See also[edit]
References[edit]
- ^ Ma Y, You X, Mai G, Tokuyasu T, Liu C (February 2018). "A human gut phage catalog correlates the gut phageome with type 2 diabetes". Microbiome. 6 (1): 24. doi:10.1186/s40168-018-0410-y. PMC 5796561. PMID 29391057.
- ^ Townsend EM, Kelly L, Muscatt G, Box JD, Hargraves N, Lilley D, Jameson E (2021-06-04). "The Human Gut Phageome: Origins and Roles in the Human Gut Microbiome". Frontiers in Cellular and Infection Microbiology. 11: 643214. doi:10.3389/fcimb.2021.643214. PMC 8213399. PMID 34150671.
- ^ Modi SR, Lee HH, Spina CS, Collins JJ (July 2013). "Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome". Nature. 499 (7457): 219–222. Bibcode:2013Natur.499..219M. doi:10.1038/nature12212. PMC 3710538. PMID 23748443.
- ^ Virgin HW (March 2014). "The virome in mammalian physiology and disease". Cell. 157 (1): 142–150. doi:10.1016/j.cell.2014.02.032. PMC 3977141. PMID 24679532.
- ^ Keen EC (January 2015). "A century of phage research: bacteriophages and the shaping of modern biology". BioEssays. 37 (1): 6–9. doi:10.1002/bies.201400152. PMC 4418462. PMID 25521633.
- ^ Górska A, Peter S, Willmann M, Autenrieth I, Schlaberg R, Huson DH (June 2018). "Dynamics of the human gut phageome during antibiotic treatment". Computational Biology and Chemistry. 74: 420–427. doi:10.1016/j.compbiolchem.2018.03.011. PMID 29567068. S2CID 4222429.
- ^ Shkoporov AN, Ryan FJ, Draper LA, Forde A, Stockdale SR, Daly KM, et al. (April 2018). "Reproducible protocols for metagenomic analysis of human faecal phageomes". Microbiome. 6 (1): 68. doi:10.1186/s40168-018-0446-z. PMC 5892011. PMID 29631623.