Monica Riley
Monica Riley | |
|---|---|
| Born | 1926 |
| Died | October 11, 2013 (aged 86–87) |
| Citizenship | American |
| Alma mater | Smith College, University of California Berkeley |
| Known for | Messenger RNA, Escherichia coli genome |
| Scientific career | |
| Institutions | University of California Davis, Stony Brook University, Marine Biological Laboratory in Woods Hole |
| Thesis | Selective destruction of genetic material and its effect on ¹-galactosidase synthesis in Escherichia coli (1960) |
Monica Riley (1926 – October 11, 2013) was an American scientist who contributed to the discovery of messenger RNA in her Ph.D work with Arthur Pardee, and was later a pioneer in the exploration and computer representation of the Escherichia coli genome.
Career[edit]
After graduating from Smith College with a chemistry degree in 1947, she studied Biochemistry at University of California Berkeley with Pardee.[1][2] Her Ph.D. work, together with the PaJaMo experiment, ruled out ribosomes as carriers of information to synthesize protein, leading to the discovery of messenger RNA.[3] After holding faculty positions at University of California Davis and Stony Brook University, she moved to the Marine Biological Laboratory in Woods Hole, staying there until age 80.[2]
As a senior scientist at MBL she was one of the four founding faculty members of the Josephine Bay Paul Center for Comparative Molecular Biology and Evolution led by Mitchell Sogin.[4] During this time, she co-founded the EcoCyc database of Escherichia coli metabolism,[5] leading the curation of metabolic pathways and genome information for Escherichia coli for over a decade,[6] and developed classification systems for genes and proteins (including MultiFun), which were forerunners of gene ontology.[1][2]
Selected publications[edit]
- Blattner, F. R. (1997-09-05). "The Complete Genome Sequence of Escherichia coli K-12". Science. 277 (5331): 1453–1462. doi:10.1126/science.277.5331.1453. PMID 9278503.
- Riley, M. (2006-01-08). "Escherichia coli K-12: a cooperatively developed annotation snapshot--2005". Nucleic Acids Research. 34 (1): 1–9. doi:10.1093/nar/gkj405. ISSN 0305-1048. PMC 1325200. PMID 16397293.
- Karp, P. D. (2002-01-01). "The EcoCyc Database". Nucleic Acids Research. 30 (1): 56–58. doi:10.1093/nar/30.1.56. PMC 99147. PMID 11752253.
- Riley, M (1993-12-01). "Functions of the gene products of Escherichia coli". Microbiological Reviews. 57 (4): 862–952. doi:10.1128/mr.57.4.862-952.1993. PMC 372942. PMID 7508076.
References[edit]
- ^ a b Olena, Abby (November 7, 2013). "Genomics Pioneer Dies". The Scientist.
- ^ a b c Serres, Greta. "Monica Riley (1926 - 2013)". Marine Biological Laboratory in Woods Hole. Archived from the original on 2015-04-15.
- ^ Crick, Francis (1988). What Mad Pursuit. Basic Books. pp. 118–119. ISBN 9780465091379.
- ^ "Monica Riley (1926 – 2013)". The Bay Paul Center. 2013-10-29. Archived from the original on 2021-01-28. Retrieved 2023-02-21.
- ^ Karp, Peter; Riley, Monica; Paley, Suzanne M.; Pelligrini-Toole, Alida (1996). "EcoCyc: an encyclopedia of Escherichia coli genes and metabolism". Nucleic Acids Research. 24 (1): 32–39. doi:10.1093/nar/24.1.32. PMC 145574. PMID 8594595.
- ^ Riley, M. (2006-01-08). "Escherichia coli K-12: a cooperatively developed annotation snapshot--2005". Nucleic Acids Research. 34 (1): 1–9. doi:10.1093/nar/gkj405. ISSN 0305-1048. PMC 1325200. PMID 16397293.
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