Melvin Ramsay

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Andrew Melvin Ramsay (1901–1990) was a British physician, who is known for his research and advocacy on myalgic encephalomyelitis (ME), a chronic disease causing muscle weakness and cognitive dysfunction. Ramsay worked as a consultant at the Royal Free Hospital in London during a mysterious 1955 disease outbreak of what later became known as ME. He studied the disease and similar outbreaks elsewhere. Work by Ramsay showed that although ME seldom caused death, the disease could be highly disabling.

Upset by the lack of sympathy for long-term sufferers, he became their lifelong advocate and co-founded the ME Association. In 1986 he published the first case definition of ME. Two research grants are named after him: the Ramsay research grant from the Solve ME/CFS Initiative and the Ramsay Research Fund of the ME Association.

Early life and career[edit]

Melvin Ramsay was born in Preston, Lancashire in 1901. He attended secondary school at the Mackie Academy in Stonehaven, Scotland and, in 1923, obtained a Master of Arts degree from the University of Aberdeen and completed an undergraduate medical degree there in 1926.

From 1926 to 1935, he practiced medicine in South Africa.[1] He then returned to the United Kingdom to work at Fulham Hospital. In 1937, he moved to the North Western Fevers Hospital. His duties included the education of nurses and medical undergraduates on the practical aspects of managing infectious diseases.[1] By 1939, he attained an MD degree, again from Aberdeen, based on a thesis investigating findings in 1205 cases of puerperal sepsis, a type of infection that can occur after miscarriage or birth.[1]

Upon the integration of the North Western Fevers Hospital into the Royal Free Hospital in 1947, Ramsay became the consultant physician for the Infectious Diseases Department. Additionally, he served as a consultant for smallpox to the Ministry of Health and worked as a lecturer on infectious diseases at the University of London[1] and at the London School of Hygiene and Tropical Medicine.[2]

Work on myalgic encephalomyelitis[edit]

Differences and similarities (in orange) between Ramsay's case definition of ME compared to the International Consensus Criteria of ME.[3]

Ramsay worked in the Royal Free Hospital in 1955 when an unknown infection affecting 300 staff raged between July and November, which required the hospital to close down.[4][5] The disease, initially dubbed the Royal Free Disease, was renamed benign myalgic encephalomyelits in a Lancet article the following year.[4][5] Ramsay studied the outbreak and found similar individual cases in north-east London. Furthermore, he described comparable outbreaks in Cumbria, England and Durban, South Africa.[5]

In 1970, two psychiatrists in the UK published an paper concluding that ME outbreaks were forms of hysteria. This was based on the fact that women were affected more than men, and that tests were unable to detect physical changes. Ramsay strongly refuted this finding, but many clinicians accepted that this was a possible explanation.[6]: 28 

Ramsay became deeply upset by the absence of empathy extended to individuals enduring long-term suffering from ME, and advocated for them for the rest of his life.[7] In 1976[7] or 1978[8] he co-founded the ME Association, a UK research funding and advocacy organisation for people with ME/CFS. He acted as its president for several years,[8] or lifelong[7] and remained active in it until his death.[9]

Work by Ramsay showed that although ME seldom caused death, the disease could be highly disabling. Consequently, the term benign was removed from its description.[6]: 28  Ramsay suggested that mitochondrial dysfunction may involved in the muscle fatigue in ME.[10]

In 1986 he published the first case definition of ME in his book Postviral Fatigue Syndrome: The Saga of Royal Free Disease.[11] In a second edition of the same book (now renamed Myalgic Encephalomyelitis and Postviral Fatigue States: The Saga of the Royal Free Disease), he named three features of the disease: "(1) muscle fatiguability after minimal exertion and a delay in the restoration of muscle power; (2) cerebral dysfunction, and (3) impaired circulation".[12]

After multiple similar outbreaks in the United States, the US Centers for Disease Control and Prevention proposed a new definition and name of the illness to chronic fatigue syndrome.[6]: 29  From this point on, ME became associated with chronic fatigue syndrome. More recently, the hybrid term myalgic encephalomyelitis/chronic fatigue syndome (ME/CFS) has become standard in clinical use.[4]

Two research grants are named after him: the Ramsay research grant from the U.S. Solve ME/CFS Initiative[13] and the Ramsay Research Fund of the ME Association.[8]

Personal life and death[edit]

His wife, Jesse[7] or Jess Ramsay (née Murray)[a] was a fellow Scot.[2] His daughter Louie Ramsay was born Molteno, South Africa in 1929.[15][1]

Ramsay was deeply religious, and his religion impacted his philosophy of life. Ronald Emold, with whom he co-authored a book, described him as "compassionate" and "young at heart".[7] He died on 19 March 1990, the year after his wife died.[2]

Publications[edit]

Books[edit]

  • Ramsay, A. Melvin; Emold, Ronald (1967). Infectious Diseases. Heineman Medical. ISBN 9780433272502.
  • Ramsay, A. Melvin (1986). Myalgic Encephalomyelitis and Postviral Fatigue States: The Saga of Royal Free Disease, (originally titled Postviral Fatigue Syndrome: The Saga of Royal Free Disease). Gower Medical. ISBN 978-0906923993.[16][5]

Journal publications[edit]

Notes[edit]

  1. ^ A newspaper detailed the arrival of Jess Murray as Dr Ramsay's fiancée in Molteno[14]

References[edit]

  1. ^ a b c d e Ramsay, A.M.; Dowsett, E.G. (1992). "Myalgic Encephalomyelitis - Then and Now: An Epidemiological Introduction". In Hyde, Byron M.; Goldstein, Jay A; Levine, Paul (eds.). The Clinical and Scientific Basis of Myalgic Encephalomyelitis – Chronic Fatigue Syndrome. Nightingale Research Foundation. pp. 81–82. ISBN 978-0969566205.
  2. ^ a b c "A. M. Ramsay MD". BMJ: British Medical Journal. 300 (6734): 1269. 1990. ISSN 0959-8138. JSTOR 29707856. Archived from the original on 29 October 2023. Retrieved 4 November 2023.
  3. ^ Twisk, Frank (2019). "Myalgic Encephalomyelitis or What? The International Consensus Criteria". Diagnostics. 9 (1): 1. doi:10.3390/diagnostics9010001. ISSN 2075-4418. PMC 6468846. PMID 30577429.
  4. ^ a b c Waters, F. G.; McDonald, G. J.; Banks, S.; Waters, R. A. (2 April 2020). "Myalgic Encephalomyelitis (ME) outbreaks can be modelled as an infectious disease: a mathematical reconsideration of the Royal Free Epidemic of 1955". Fatigue: Biomedicine, Health & Behavior. 8 (2): 70–83. doi:10.1080/21641846.2020.1793058. ISSN 2164-1846. S2CID 221097925. Archived from the original on 29 October 2023. Retrieved 4 November 2023.
  5. ^ a b c d Sakula, Alex (1 May 1988). "£3.50 paperback Post-viral Fatigue Syndrome: The Saga of Royal Free Disease, A. Melvin Ramsay, Gower Medical Publishing, Amsterdam, New York and Oxford (1986), p. 64". Journal of Infection. 16 (3): 315. doi:10.1016/S0163-4453(88)97988-1. ISSN 0163-4453. Archived from the original on 29 October 2023. Retrieved 4 November 2023.
  6. ^ a b c Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine (10 February 2015). Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (PDF). PMID 25695122. Archived (PDF) from the original on 20 January 2017. Retrieved 28 July 2020.
  7. ^ a b c d e Emold, Ronald (19 May 1990). "Dr Melvin Ramsay: ME generation champion". The Guardian. p. 21. Archived from the original on 29 October 2023. Retrieved 4 November 2023.
  8. ^ a b c "Research". The ME Association. Archived from the original on 1 November 2023. Retrieved 1 November 2023.
  9. ^ "Mission Statement". The ME Association. Archived from the original on 30 October 2023. Retrieved 30 October 2023.
  10. ^ Ramsay, A M (1 November 1978). "'Epidemic neuromyasthenia' 1955–1978". Postgraduate Medical Journal. 54 (637): 718–721. doi:10.1136/pgmj.54.637.718. ISSN 0032-5473. PMC 2425324. PMID 746017.
  11. ^ Lim, Eun-Jin; Son, Chang-Gue (29 July 2020). "Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)". Journal of Translational Medicine. 18 (1): 289. doi:10.1186/s12967-020-02455-0. ISSN 1479-5876. PMC 7391812. PMID 32727489.
  12. ^ Sunnquist, Madison; Jason, Leonard A.; Nehrke, Pamela; Goudsmit, Ellen M. (2017). "A Comparison of Case Definitions for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome". Journal of Chronic Diseases and Management. 2 (2): 1013. ISSN 2573-1300. PMC 5663312. PMID 29104961.
  13. ^ "Resources for researchers". European ME Coalition. Archived from the original on 1 November 2023. Retrieved 1 November 2023.
  14. ^ "The Daily Representative – Moreno". South Africa. London, England. 11 March 1927. Archived from the original on 31 October 2023. Retrieved 31 October 2023 – via www.eggsa.org.
  15. ^ Coveney, Michael (15 March 2011). "Louie Ramsay obituary". The Guardian. ISSN 0261-3077. Archived from the original on 4 December 2023. Retrieved 29 October 2023.
  16. ^ Wookey, Celia (December 1987). "Primary Care Book Shelf: POST-VIRAL FATIGUE SYNDROME:The saga of Royal Free disease" (PDF). Journal of the Royal College of General Practitioners. Archived (PDF) from the original on 28 October 2023. Retrieved 4 November 2023.
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