Lydia W. S. Finley

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Lydia W. S. Finley
AwardsSearle Scholar
Scientific career
FieldsMetabolism, Stem Cell Biology
InstitutionsMemorial Sloan Kettering
Doctoral advisorMarcia Haigis
Other academic advisorsCraig Thompson
Websitehttps://www.mskcc.org/research/ski/labs/lydia-finley

Lydia W. S. Finley is an American scientist and an assistant member at the Cell Biology Program at Memorial Sloan Kettering Cancer Center and an assistant professor at Weill Cornell Medical College. Finley is known for her contributions to understanding the metabolic underpinnings of stem cell fate.

Biography[edit]

Finley received her Bachelor of Science (BS) degree summa cum laude from Yale University. Finley completed her PhD at Harvard Medical School, where she worked in the laboratory of Marcia Haigis. Finley then worked as a postdoctoral fellow in the laboratory of Craig Thompson at Memorial Sloan Kettering Cancer Center. After completing her postdoctoral work, Finley opened her own laboratory in 2017, which is located in the Memorial Sloan Kettering Cancer Center.[1][2][3]

Finley has received various awards for her work. These include the Dale F. Frey Award for Breakthrough Scientists from the Damon Runyon Cancer Research Foundation and the Searle Scholars Award. Finley currently serves as an associate editor for Cancer & Metabolism[4] and a reviewing editor at eLife.[5] As of April 2022, Finley has authored over 40 publications and has an h-index of 30.[6]

Scientific contributions[edit]

Finley's research has focused on interrogating the connections between metabolites and their role in regulating embryonic stem cell self-renewal and cell fate decisions. Notably, as a postdoctoral fellow, Finley and Bryce W. Carey discovered that intracellular α-ketoglutarate levels regulated chromatin and gene expression, and contributes to embryonic stem cell renewal.[7][8] In 2022, Finley and co-authors published a paper describing a non-canonical arm of the TCA cycle.[9][10][11][12]

Selected awards and honors[edit]

Selected publications[edit]

  • Carey BW*, Finley LW*, Cross JR, Allis CD, Thompson CB. Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 2015;518(7539):413-416. doi:10.1038/nature13981[16]
  • Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature. 2022 Mar;603(7901):477-481. doi: 10.1038/s41586-022-04475-w. Epub 2022 Mar 9. PMID: 35264789; PMCID: PMC8934290.[17]

References[edit]

  1. ^ "Lydia Finley, PhD". Pershing Square Foundation. Retrieved 2022-04-09.
  2. ^ "Lydia Finley | Haigis Lab". haigis.hms.harvard.edu. Retrieved 2022-04-09.
  3. ^ "Cell scientist to watch – Lydia Finley". Journal of Cell Science. 135 (7): jcs260023. 2022-04-04. doi:10.1242/jcs.260023. ISSN 0021-9533. S2CID 247964605.
  4. ^ "Cancer & Metabolism". BioMed Central. Retrieved 2022-04-09.
  5. ^ "Editors for Stem Cells and Regenerative Medicine". eLife. Retrieved 2022-04-09.
  6. ^ "Lydia Finley". scholar.google.com. Retrieved 2022-04-09.
  7. ^ "Cell scientist to watch – Lydia Finley". Journal of Cell Science. 135 (7): jcs260023. 2022-04-04. doi:10.1242/jcs.260023. ISSN 0021-9533. S2CID 247964605.
  8. ^ Carey, Bryce W.; Finley, Lydia W.S.; Cross, Justin R.; Allis, C. David; Thompson, Craig B. (2015-02-19). "Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells". Nature. 518 (7539): 413–416. Bibcode:2015Natur.518..413C. doi:10.1038/nature13981. ISSN 0028-0836. PMC 4336218. PMID 25487152.
  9. ^ Arnold, Paige K.; Jackson, Benjamin T.; Paras, Katrina I.; Brunner, Julia S.; Hart, Madeleine L.; Newsom, Oliver J.; Alibeckoff, Sydney P.; Endress, Jennifer; Drill, Esther; Sullivan, Lucas B.; Finley, Lydia W. S. (March 2022). "A non-canonical tricarboxylic acid cycle underlies cellular identity". Nature. 603 (7901): 477–481. Bibcode:2022Natur.603..477A. doi:10.1038/s41586-022-04475-w. ISSN 1476-4687. PMC 8934290. PMID 35264789.
  10. ^ "Sloan Kettering Institute Scientists Discover a new twist on an 80-year-old biochemical pathway". EurekAlert!. Retrieved 2022-04-09.
  11. ^ "New twist on an 80-year-old biochemical pathway". ScienceDaily. Retrieved 2022-04-09.
  12. ^ "Remember Memorizing the Krebs Cycle? An Alternate Version Was Just Discovered | Cell And Molecular Biology". Labroots. Retrieved 2022-04-09.
  13. ^ "Meet Our Scientists". Damon Runyon. Retrieved 2022-04-09.
  14. ^ "Lydia Finley". Searle Scholars Program. Retrieved 2022-04-09.
  15. ^ "Lydia Finley, PhD". Pershing Square Foundation. Retrieved 2022-04-09.
  16. ^ Carey, Bryce W.; Finley, Lydia W.S.; Cross, Justin R.; Allis, C. David; Thompson, Craig B. (2015-02-19). "Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells". Nature. 518 (7539): 413–416. Bibcode:2015Natur.518..413C. doi:10.1038/nature13981. ISSN 0028-0836. PMC 4336218. PMID 25487152.
  17. ^ Arnold, Paige K.; Jackson, Benjamin T.; Paras, Katrina I.; Brunner, Julia S.; Hart, Madeleine L.; Newsom, Oliver J.; Alibeckoff, Sydney P.; Endress, Jennifer; Drill, Esther; Sullivan, Lucas B.; Finley, Lydia W. S. (March 2022). "A non-canonical tricarboxylic acid cycle underlies cellular identity". Nature. 603 (7901): 477–481. Bibcode:2022Natur.603..477A. doi:10.1038/s41586-022-04475-w. ISSN 1476-4687. PMC 8934290. PMID 35264789.
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