Karen Adelman

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Karen Adelman
NationalityAmerican
Alma mater
Known forGene regulation, chromatin, cancer, development
Scientific career
Fields
Institutions
Academic advisorsJohn T. Lis
WebsiteAdelman Lab

Karen Adelman is an American biologist who is the Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology at the Harvard Medical School in Boston. The Adelman lab made significant contributions to the field of gene regulation by pioneering genomic studies of RNA polymerase II (Pol II) pausing during early transcription elongation. Their findings fundamentally changed the way we understand the regulation of gene expression.[1][2][3]

Education[edit]

Adelman completed her undergraduate studies in biology at the State University of New York, Buffalo and earned her Ph.D. in molecular and cellular genetics from the Université de Paris VI in Paris in 1999.[4][5]

Career and research[edit]

In 1999, Adelman underwent her postdoctoral training in the Department of Microbiology and Immunology and the Department of Molecular Biology and Genetics at Cornell University under John T. Lis.[6][7] In 2005, she founded her laboratory at the National Institute of Environmental Health Sciences (NIH) and earned a promotion to Senior Investigator in 2011.[8][9][10][11] Later, in 2016, she became a Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School.[12]

The primary objective of the Adelman laboratory is to understand how cells rapidly yet balanced respond to external signals at the transcriptional and epigenetic levels. To investigate the dynamics of gene expression, the lab employs a blend of genomics, genetics, and biochemistry, with a particular emphasis on examining developmental and immune-responsive systems.[13][14]

Awards and honours[edit]

References[edit]

  1. ^ "Karen Adelman". 2 February 2024.
  2. ^ "Karen Adelman | Harvard Catalyst Profiles | Harvard Catalyst".
  3. ^ "Karen Adelman | Epigenetics and Epigenomics in Health & Disease 2022". 3 November 2021.
  4. ^ "Colleagues: Recently Tenured | NIH Intramural Research Program".
  5. ^ https://www.jbc.org/article/S0021-9258(18)68063-9/fulltext
  6. ^ Adelman, Karen; Salmon, Brandy; Baines, Joel D. (2001). "Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machinery". Proceedings of the National Academy of Sciences. 98 (6): 3086–3091. Bibcode:2001PNAS...98.3086A. doi:10.1073/pnas.061555698. PMC 30611. PMID 11248036.
  7. ^ Adelman, Karen; La Porta, Arthur; Santangelo, Thomas J.; Lis, John T.; Roberts, Jeffrey W.; Wang, Michelle D. (2002). "Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior". Proceedings of the National Academy of Sciences. 99 (21): 13538–13543. Bibcode:2002PNAS...9913538A. doi:10.1073/pnas.212358999. PMC 129709.
  8. ^ "Colleagues: Recently Tenured | NIH Intramural Research Program".
  9. ^ Muse, Ginger W.; Gilchrist, Daniel A.; Nechaev, Sergei; Shah, Ruchir; Parker, Joel S.; Grissom, Sherry F.; Zeitlinger, Julia; Adelman, Karen (2007). "RNA polymerase is poised for activation across the genome". Nature Genetics. 39 (12): 1507–1511. doi:10.1038/ng.2007.21. PMC 2365887. PMID 17994021.
  10. ^ Adelman, Karen; Lis, John T. (2012). "Promoter-proximal pausing of RNA polymerase II: Emerging roles in metazoans". Nature Reviews Genetics. 13 (10): 720–731. doi:10.1038/nrg3293. PMC 3552498. PMID 22986266.
  11. ^ Nechaev, Sergei; Fargo, David C.; Dos Santos, Gilberto; Liu, Liwen; Gao, Yuan; Adelman, Karen (2010). "Global Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II in Drosophila". Science. 327 (5963): 335–338. Bibcode:2010Sci...327..335N. doi:10.1126/science.1181421. PMC 3435875. PMID 20007866.
  12. ^ Core, L.; Adelman, K. (2019). "Promoter-proximal pausing of RNA polymerase II: A nexus of gene regulation". Genes & Development. 33 (15–16): 960–982. doi:10.1101/gad.325142.119. PMC 6672056. PMID 31123063.
  13. ^ "Karen L. Adelman | American Academy of Arts and Sciences".
  14. ^ "A Conversation with Karen Adelman". Cold Spring Harbor Symposia on Quantitative Biology. 84: 253–255. 2019. doi:10.1101/sqb.2019.84.039008. PMID 31862808.
  15. ^ "Karen L. Adelman | American Academy of Arts and Sciences".
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