Aceglatone

Aceglatone
Clinical data
Trade names	Glucaron
Other names	D-Glucaric acid di-γ-lactone 2,5-diacetate; 2,5-Di-O-acetyl-D-glucaro-1,4:6,3-dilactone; 2,5-Di-O-acetyl-D-glucosaccharo-1,4:6,3-dilactone
AHFS/Drugs.com	International Drug Names
ATC code	none;
Identifiers
	IUPAC name (3R,3aR,6S,6aR)-2,5-Dioxohexahydrofuro[3,2-b]furan-3,6-diyl diacetate;
CAS Number	642-83-1 ;
PubChem CID	636372;
ChemSpider	599998 ;
UNII	347Q3OOJ13;
ChEMBL	ChEMBL2103781 ;
CompTox Dashboard (EPA)	DTXSID0048848 ;
Chemical and physical data
Formula	C10H10O8
Molar mass	258.182 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	185 to 186 °C (365 to 367 °F)
	SMILES O=C1O[C@H]2[C@@H](OC(=O)C)C(=O)O[C@H]2[C@@H]1OC(=O)C;
	InChI InChI=1S/C10H10O8/c1-3(11)15-7-5-6(18-9(7)13)8(10(14)17-5)16-4(2)12/h5-8H,1-2H3/t5-,6-,7-,8+/m1/s1 ; Key:ZOZKYEHVNDEUCO-XUTVFYLZSA-N ;
	(what is this?) (verify)

Aceglatone (Glucaron) is an antineoplastic drug available in Japan.^[2]

It is an inhibitor of the enzyme β-glucuronidase.^[3]

References[edit]

^ Merck Index, 11th Edition, 20
^ Glucaron, drugs.com
^ Iida R, Nagata S, Kakimoto M, Akaike H, Watanabe H, Shioya A (1965). "2,5-Di-O-acetyl-D-glucosaccharo-(1→4)(6→3)-dilactone, a new potent β-glucuronidase inhibitor". Japanese Journal of Pharmacology. 15 (1): 88–90. doi:10.1254/jjp.15.88. PMID 14348597.

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