User:Mr. Ibrahem/Varenicline
Clinical data | |
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Trade names | Champix, Chantix, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a606024 |
License data |
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Pregnancy category |
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Routes of administration | By mouth |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | <20% |
Metabolism | Limited (<10%) |
Elimination half-life | 24 hours |
Excretion | Kidney (81–92%) |
Identifiers | |
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Chemical and physical data | |
Formula | C13H13N3 |
Molar mass | 211.267 g·mol−1 |
3D model (JSmol) | |
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Varenicline, sold under the trade name Champix among others, is a medication used help people stop smoking.[1] It is the recommended initial treatment together with behavioral support.[2][3] It helps one of every 11 people who smoke, stop for at least six months.[4] Varenicline is taken by mouth.[1]
Common side effects include unusual dreams, nausea, and constipation.[1] Serious side effects may include depression, anxiety, seeing or hearing things that others do not, allergic reactions, thoughts of suicide, and seizures.[1] There is no clear harm from use in human pregnancy but such use has not been well studied and there may be harm in pregnancy in other animals.[5] It works by binding to a type of nicotinic acetylcholine receptors in the brain, decreasing the ability of nicotine to attach, and thus reducing the desire to smoke.[1]
Varenicline was approved for medical use in the United States and Europe in 2006.[1][6] As of 2020 it costs about 440 USD in the United States for the first month (7.60 USD per tablet).[7][8] In the United Kingdom this amount is about 55 pounds.[3] It may become avaliable as a generic medication in the US in 2020.[7]
References[edit]
- ^ a b c d e f "Varenicline tartrate Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 19 August 2020.
- ^ Leone, Frank T.; Zhang, Yuqing; Evers-Casey, Sarah; Evins, A. Eden; Eakin, Michelle N.; Fathi, Joelle; Fennig, Kathleen; Folan, Patricia; Galiatsatos, Panagis; Gogineni, Hyma; Kantrow, Stephen; Kathuria, Hasmeena; Lamphere, Thomas; Neptune, Enid; Pacheco, Manuel C.; Pakhale, Smita; Prezant, David; Sachs, David P. L.; Toll, Benjamin; Upson, Dona; Xiao, Dan; Cruz-Lopes, Luciane; Fulone, Izabela; Murray, Rachael L.; O’Brien, Kelly K.; Pavalagantharajah, Sureka; Ross, Stephanie; Zhang, Yuan; Zhu, Meng; Farber, Harold J. (15 July 2020). "Initiating Pharmacologic Treatment in Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline". American Journal of Respiratory and Critical Care Medicine. 202 (2): e5–e31. doi:10.1164/rccm.202005-1982ST.
- ^ a b BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 515. ISBN 9780857113658.
- ^ Crawford, P; Cieslak, D (September 2017). "Varenicline for Smoking Cessation". American Family Physician. 96 (5): Online. PMID 28925657. Archived from the original on 2019-05-26. Retrieved 2019-05-26.
- ^ "Varenicline Use During Pregnancy". Drugs.com. Archived from the original on 27 January 2021. Retrieved 19 August 2020.
- ^ European Medicines Agency (2011-01-28). "EPAR summary for the public. Champix varenicline". London. Archived from the original on 2011-07-20. Retrieved 2011-02-14.
- ^ a b "Varenicline Prices, Coupons & Savings Tips". GoodRx. Retrieved 19 August 2020.
- ^ "NADAC as of 2020-08-19 | Data.Medicaid.gov". Centers for Medicare and Medicaid Services. Retrieved 19 August 2020.
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