User:Mr. Ibrahem/Prasterone
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| Clinical data | |
|---|---|
| Trade names | Astenile, Cetovister, 17-Chetovis, others[1] |
| Other names | EL-10; GL-701; KYH-3102; Androst-5-en-3β-ol-17-one; 3β-Hydroxyandrost-5-en-17-one; 5,6-Didehydroepiandrosterone;[2] Dehydroisoepiandrosterone[1] |
| AHFS/Drugs.com | Monograph |
| Routes of administration | By mouth, vaginal (insert), intramuscular injection (as prasterone enanthate), injection (as prasterone sodium sulfate) |
| Drug class | Androgen; Anabolic steroid; Estrogen; Neurosteroid |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 50%[3] |
| Metabolism | Liver[3] |
| Metabolites | • Androsterone[3] • Etiocholanolone[3] • @@@2@@@ sulfate[3] • Androstenedione[3] • Androstenediol[3] • Testosterone[3] • Dihydrotestosterone • Androstanediol[3] • Estrone • Estradiol |
| Elimination half-life | DHEA: 25 minutes[4] DHEA-S: 11 hours[4] |
| Excretion | Urine |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C19H28O2 |
| Molar mass | 288.431 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 148.5 °C (299.3 °F) |
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Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand names Intrarosa among others, is a medication and dietary supplement.[5][7] As a medication it is used to treat postmenopausal women with vaginal atrophy.[5] For this purpose it is used in the vagina.[5] As a supplements it is sold with claims of anti-aging properties.[7]
Common side effects include vaginal discharge and abnormal Pap smear.[8] Other side effects may include weight change, acne, oily skin, and increased hair growth.[6][7] It is a naturally occurring steroid hormone which is converted into androgens and estrogens.[9]
Prasterone was discovered in 1934.[7] An association between DHEA levels and aging was reported in 1965.[3] The compound started being used for health claims in the 1980s.[3] It was approved for medical use in Europe in 2018.[5] In the United Kingdom 4 weeks of treatment costs the NHS about £16 in 2021 while in the United States this amount costs about 210 USD.[6][8] The marketing of over-the-counter supplements is allowed in the United States.[3]
References[edit]
- ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 641–. ISBN 978-1-4757-2085-3. Archived from the original on 22 October 2020. Retrieved 27 September 2021.
- ^ James Devillers (27 April 2009). Endocrine Disruption Modeling. CRC Press. pp. 339–. ISBN 978-1-4200-7636-3. Archived from the original on 19 April 2021. Retrieved 27 September 2021.
- ^ a b c d e f g h i j k l Melanie Johns Cupp; Timothy S. Tracy (10 December 2002). Dietary Supplements: Toxicology and Clinical Pharmacology. Springer Science & Business Media. pp. 123–147. ISBN 978-1-59259-303-3. Archived from the original on 20 August 2020. Retrieved 27 September 2021.
- ^ a b B.J. Oddens; A. Vermeulen (15 November 1996). Androgens and the Aging Male. CRC Press. pp. 5–. ISBN 978-1-85070-763-9. Archived from the original on 8 March 2021. Retrieved 27 September 2021.
- ^ a b c d e "Intrarosa". Archived from the original on 21 March 2021. Retrieved 29 October 2021.
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 879. ISBN 978-0857114105.
- ^ a b c d e Rutkowski K, Sowa P, Rutkowska-Talipska J, Kuryliszyn-Moskal A, Rutkowski R (July 2014). "Dehydroepiandrosterone (DHEA): hypes and hopes". Drugs. 74 (11): 1195–207. doi:10.1007/s40265-014-0259-8. PMID 25022952. S2CID 26554413.
- ^ a b c "Prasterone Monograph for Professionals". Drugs.com. Retrieved 29 October 2021.
- ^ Prough RA, Clark BJ, Klinge CM (April 2016). "Novel mechanisms for DHEA action". J. Mol. Endocrinol. 56 (3): R139–55. doi:10.1530/JME-16-0013. PMID 26908835.