User:Mr. Ibrahem/Fluvastatin

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Mr. Ibrahem/Fluvastatin
Clinical data
Trade namesLescol, others
AHFS/Drugs.comMonograph
MedlinePlusa694010
Pregnancy
category
  • AU: D
Routes of
administration		By mouth (capsules, tablets)
Drug classStatin[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability24–30%[2][3]
Protein binding>98%[3]
MetabolismLiver: CYP2C9 (75%), CYP3A4 (20%), CYP2C8 (5%)[3][4]
Elimination half-life1–3 hours (capsule), 9 hours (XR formulations)[3][4]
ExcretionFaeces (95%), urine (5%)[3]
Identifiers
  • (3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Chemical and physical data
FormulaC24H26FNO4
Molar mass411.473 g·mol−1
3D model (JSmol)
  • O=C(O)C[C@H](O)C[C@H](O)/C=C/c2c(c1ccccc1n2C(C)C)c3ccc(F)cc3
  • InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1 checkY
  • Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N checkY
  (verify)

Fluvastatin, sold under the brand name Lescol among others, is a medication used to treat high cholesterol and high triglycerides and prevent heart disease.[5][1] It is used together with diet and exercise.[1] It is taken by mouth.[5] Up to 4 weeks may be required for maximal effect.[1]

Common side effects include muscle pain, heart burn, nausea, and headaches.[1] Other side effects may include muscle breakdown, liver problems, high blood sugar, and memory problems.[1] Use during pregnancy may harm the baby.[1] It is a statin and works by blocking HMG-CoA reductase.[1]

Fluvastatin was patented in 1982 and approved for medical use in 1993.[6][1] It is on the World Health Organization's List of Essential Medicines as an alternative to simvastatin.[7] It is available as a generic medication.[5] In the United Kingdom 4 weeks of medication costs the NHS about £3 to 20 per month as of 2021.[5]

References[edit]

  1. ^ a b c d e f g h i j "Fluvastatin Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 13 December 2021.
  2. ^ Haberfeld H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.
  3. ^ a b c d e Neuvonen PJ, Backman JT, Niemi M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955. S2CID 11716425.
  4. ^ a b "Lescol, Lescol XR (fluvastatin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 18 March 2014. Retrieved 18 March 2014.
  5. ^ a b c d e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 218. ISBN 978-0857114105.
  6. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 472. ISBN 9783527607495. Archived from the original on 2020-08-19. Retrieved 2021-10-05.
  7. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
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