Talk:Fibrate

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"Although less effective in lowering LDL and triglyceride levels, the ability of fibrates to increase HDL and lower triglyceride levels"

You are saying it is less effective in lowering triglycerides and then saying it does help to reduce trigylcerides. Which is it? If your intention is to say it does help reduce triglycerides I would change the sentence to " Although less effective in lowering LDL , the ability of fibrates to increase HDL and lower triglyceride levels — Preceding unsigned comment added by 2602:306:80F8:4A40:D9C3:A4DB:3125:9565 (talk) 23:11, 27 September 2016 (UTC)[reply]

Carboxylic acid?[edit]

The intro says that fibrates are carboxylic acids. But none of the structure diagrams show compounds with a -C(=O)OH group. David.Throop (talk) 22:33, 12 February 2008 (UTC)[reply]

Why "fibrate"?[edit]

Can anyone add an explanation of why fribates are named so? Do they have something to do with dietary or other kind of fiber? ~ Jeff Q (talk) 07:59, 13 December 2009 (UTC)[reply]

No relations with dietary fibers at all! Fibrates because related to fibric acid (PMID: 70343), I haven't found precise literature data but I think that, in turns, fibric acid owes its name to his structure, being a Phenoxyisobutyric acid. --Radio89 (talk) 20:34, 17 July 2012 (UTC)[reply]

I think this above is a relevant information that should be in the article. Also a hint about natural sources/origin of this compound would be nice. Is it purely synthetic, does it appear in the metabolism of any living organism, etc. 80.98.79.37 (talk) 22:57, 21 July 2017 (UTC).[reply]

Is there really evidence of fibrates being used since 1930?[edit]

Hello everyone, reference #6 to a patent is used as an evidence that fibrates were used since 1930s. The patent describes a mixture of tar oil and fibrate (among other things), and indeed, references two other patents: one from 1936 and another from 1980. However the problem is that the 1936 patent is describing usage of tar oil in the treatment of "hysteria", but has nothing to do with fibrates themselves. I think that the person who originally inserted this sentences into the article might have misunderstood the 1936 patent. Until there is trustworthy evidence, we should remove the claim of the drug being used since 1930, because the source given in this article is not justifying that claim. — Preceding unsigned comment added by Mchan12345 (talk • contribs) 12:30, 25 February 2019 (UTC)[reply]

The earliest mention of fibrate usage that I found on PubMed pertains to year 1962: https://www.ncbi.nlm.nih.gov/pubmed/13921051. I suggest modifying the disputed "1930s" claim to 1962. — Preceding unsigned comment added by Mchan12345 (talk • contribs) 13:51, 25 February 2019 (UTC)[reply]

Doing that right now, since no one has come up with a reference. SoloBear89 08:19, 12 July 2022 (UTC)[reply]