User:Mr. Ibrahem/Octreotide

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Mr. Ibrahem/Octreotide
Clinical data
Trade namesSandostatin, Bynfezia Pen, Mycapssa, others
AHFS/Drugs.comMonograph
MedlinePlusa693049
License data
Pregnancy
category
  • AU: C
Routes of
administration		Subcutaneous, intramuscular, intravenous, by mouth
Drug classSomatostatin[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability60% (IM), 100% (SC)
Protein binding40–65%
MetabolismLiver
Elimination half-life1.7–1.9 hours
ExcretionUrine (32%)
Identifiers
  • (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-
    [[(2R)-2-amino-3-phenyl-propanoyl]amino]-16-
    benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-
    (1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,
    15,18-pentaoxo-1,2-dithia-5,8,11,14,17-
    pentazacycloicosane-4-carboxamide
Chemical and physical data
FormulaC49H66N10O10S2
Molar mass1019.25 g·mol−1
3D model (JSmol)
  • C[C@H]([C@H]1C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)Cc2c[nH]c3c2cccc3)Cc4ccccc4)NC(=O)[C@@H](Cc5ccccc5)N)C(=O)N[C@H](CO)[C@@H](C)O)O
  • InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+/m1/s1 ☒N
  • Key:DEQANNDTNATYII-OULOTJBUSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Octreotide, sold under the brand name Sandostatin among others, is a medication used to treat carcinoid syndrome, acromegaly, congenital hyperinsulinism, and gastrointestinal bleeding due to esophageal varices.[1][2] It can be given by injection into a vein or muscle.[1] The immediate release form may be effective up to 12 hours.[1]

Common side effects include nausea, a slow heart rate, and abdominal discomfort.[1] Other side effects may include low or high blood sugar, gall bladder problems, and anaphylaxis.[1] It is unclear if use during pregnancy is safe.[3] Use is not recommended when breastfeeding.[4] It mimics the effects of natural somatostatin and inhibits the release of growth hormone, serotonin, insulin, and glucagon.[1]

It was first made in 1979, by the chemist Wilfried Bauer.[5] It was approved for medical use in the United States in 1988.[6] It is available as a generic medication.[4] In the United Kingdom it costs about 3 pounds per 50 ug dose as of 2020.[4] In the United States this amount costs about 5.30 USD as of 2020.[7]

References[edit]

  1. ^ a b c d e f g h i "Octreotide Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 25 December 2020.
  2. ^ Cat, TB; Liu-DeRyke, X (September 2010). "Medical management of variceal hemorrhage". Critical care nursing clinics of North America. 22 (3): 381–93. doi:10.1016/j.ccell.2010.02.004. PMID 20691388.
  3. ^ "Octreotide Use During Pregnancy". Drugs.com. Archived from the original on 20 January 2021. Retrieved 25 December 2020.
  4. ^ a b c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1002. ISBN 978-0-85711-369-6.
  5. ^ MD, Laura Lamps; MD, Andrew Bellizzi; MD, Wendy L. Frankel; MD, Rhonda Yantiss; MD, Scott R. Owens (2015). Neoplastic Gastrointestinal Pathology: An Illustrated Guide. Springer Publishing Company. p. 40. ISBN 978-1-936287-72-7. Archived from the original on 28 August 2021. Retrieved 25 December 2020.
  6. ^ "Octreotide Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 25 December 2020.
  7. ^ "Octreotide Prices and Octreotide Coupons". GoodRx. Retrieved 25 December 2020.
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