User:Mr. Ibrahem/Flurbiprofen
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| Clinical data | |
|---|---|
| Trade names | Ansaid, Ocufen, Strepfen |
| Other names | (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid |
| AHFS/Drugs.com | Systemic: Monograph Eye: Monograph |
| MedlinePlus | a687005 |
| Pregnancy category |
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| Routes of administration | By mouth |
| Drug class | Nonsteroidal anti-inflammatory drugs (NSAIDs)[1] |
| Pharmacokinetic data | |
| Protein binding | > 99% |
| Metabolism | Liver (CYP2C9) |
| Elimination half-life | 4.7-5.7 hours |
| Excretion | Kidney |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C15H13FO2 |
| Molar mass | 244.265 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
| Melting point | 117 °C (243 °F) |
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| (verify) | |
Flurbiprofen is a nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation.[1][3] By mouth it is used to treat painful periods, rheumatoid arthritis, and ankylosing spondylitis.[1][3] As an eye drop it is used to decrease pupil constriction during eye surgery and inflammation of the eye after surgery.[2]
Common side effects when taken by mouth include swelling, heart burn, gastrointestinal bleeding, nausea, liver problems, and anxiety.[1] Common side effects when used as an eye drop include burning, dry eyes, and large pupils.[2] Other side effects may include anaphylaxis and heart problems.[1] Use in the second half of pregnancy may harm the baby.[1] It works by blocking COX1 and COX2.[1]
Flurbiprofen was patented in 1964 and approved for medical use in 1987.[4] It became available as a generic medicaion in 1994.[5] In the United States 100 tablets of 100 mg costs about 66 USD as of 2021.[6] This amount in the United Kingdom costs about £92.[3]
References[edit]
- ^ a b c d e f g h "Flurbiprofen Monograph for Professionals". Drugs.com. Archived from the original on 28 August 2021. Retrieved 14 December 2021.
- ^ a b c "Flurbiprofen (EENT) Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 14 December 2021.
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1186. ISBN 978-0857114105.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 520. ISBN 9783527607495. Archived from the original on 2020-08-06. Retrieved 2020-10-17.
- ^ Approved Drug Products with Therapeutic Equivalence Evaluations (PDF) (36th ed.). FDA. 2014. p. 158. Archived (PDF) from the original on 2016-11-15. Retrieved 2016-11-14.
- ^ "Flurbiprofen Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 28 August 2021. Retrieved 14 December 2021.