Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 21:13, 7 November 2007 (UTC)[edit]
Proteins without matches (14)[edit]
Proteins with a High Potential Match (11)[edit]
Created (7)[edit]
Manual Inspection (Page not found) (18)[edit]
Protein Status Grid - Date: 21:13, 7 November 2007 (UTC)[edit]
Vebose Log - Date: 21:13, 7 November 2007 (UTC)[edit]
- INFO: Beginning work on ACTC1... {November 7, 2007 12:41:54 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:42:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:42:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACTC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1atn.
| PDB = {{PDB2|1atn}}, {{PDB2|1c0g}}, {{PDB2|1d4x}}, {{PDB2|1dej}}, {{PDB2|1eqy}}, {{PDB2|1esv}}, {{PDB2|1h1v}}, {{PDB2|1hlu}}, {{PDB2|1ijj}}, {{PDB2|1j6z}}, {{PDB2|1kxp}}, {{PDB2|1lcu}}, {{PDB2|1lot}}, {{PDB2|1m8q}}, {{PDB2|1ma9}}, {{PDB2|1mdu}}, {{PDB2|1mvw}}, {{PDB2|1nlv}}, {{PDB2|1nm1}}, {{PDB2|1nmd}}, {{PDB2|1nwk}}, {{PDB2|1o18}}, {{PDB2|1o19}}, {{PDB2|1o1a}}, {{PDB2|1o1b}}, {{PDB2|1o1c}}, {{PDB2|1o1d}}, {{PDB2|1o1e}}, {{PDB2|1o1f}}, {{PDB2|1o1g}}, {{PDB2|1p8z}}, {{PDB2|1qz5}}, {{PDB2|1qz6}}, {{PDB2|1rdw}}, {{PDB2|1rfq}}, {{PDB2|1rgi}}, {{PDB2|1s22}}, {{PDB2|1sqk}}, {{PDB2|1t44}}, {{PDB2|1wua}}, {{PDB2|1y64}}, {{PDB2|1yxq}}, {{PDB2|2a3z}}, {{PDB2|2a40}}, {{PDB2|2a41}}, {{PDB2|2a42}}, {{PDB2|2a5x}}, {{PDB2|2asm}}, {{PDB2|2aso}}, {{PDB2|2asp}}, {{PDB2|2btf}}, {{PDB2|2d1k}}, {{PDB2|2ff3}}, {{PDB2|2ff6}}, {{PDB2|2fxu}}, {{PDB2|2gwj}}, {{PDB2|2gwk}}, {{PDB2|2hf3}}, {{PDB2|2hf4}}, {{PDB2|2hmp}}, {{PDB2|2oan}}, {{PDB2|2q1n}}, {{PDB2|2q31}}, {{PDB2|2q36}}
| Name = Actin, alpha, cardiac muscle 1
| HGNCid = 143
| Symbol = ACTC1
| AltSymbols =; ACTC; CMD1R
| OMIM = 102540
| ECnumber =
| Homologene = 68446
| MGIid = 87905
| GeneAtlas_image1 = PBB_GE_ACTC1_205132_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005884 |text = actin filament}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 70
| Hs_Ensembl = ENSG00000159251
| Hs_RefseqProtein = NP_005150
| Hs_RefseqmRNA = NM_005159
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 32869724
| Hs_GenLoc_end = 32875181
| Hs_Uniprot = P68032
| Mm_EntrezGene = 11464
| Mm_Ensembl = ENSMUSG00000068614
| Mm_RefseqmRNA = XM_001002645
| Mm_RefseqProtein = XP_001002645
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 113738727
| Mm_GenLoc_end = 113744252
| Mm_Uniprot = Q3TG92
}}
}}
'''Actin, alpha, cardiac muscle 1''', also known as '''ACTC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).<ref>{{cite web | title = Entrez Gene: ACTC1 actin, alpha, cardiac muscle 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=70| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227-30 |year= 1997 |pmid= 8997639 |doi= }}
*{{cite journal | author=Bearer EL, Prakash JM, Li Z |title=Actin dynamics in platelets. |journal=Int. Rev. Cytol. |volume=217 |issue= |pages= 137-82 |year= 2002 |pmid= 12019562 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AQP2... {November 7, 2007 12:42:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:43:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Aquaporin 2 (collecting duct)
| HGNCid = 634
| Symbol = AQP2
| AltSymbols =; AQP-CD; MGC34501; WCH-CD
| OMIM = 107777
| ECnumber =
| Homologene = 20137
| MGIid = 1096865
| GeneAtlas_image1 = PBB_GE_AQP2_206672_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015250 |text = water channel activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0007588 |text = excretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 359
| Hs_Ensembl = ENSG00000167580
| Hs_RefseqProtein = NP_000477
| Hs_RefseqmRNA = NM_000486
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 48630796
| Hs_GenLoc_end = 48638926
| Hs_Uniprot = P41181
| Mm_EntrezGene = 11827
| Mm_Ensembl = ENSMUSG00000023013
| Mm_RefseqmRNA = NM_009699
| Mm_RefseqProtein = NP_033829
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 99407090
| Mm_GenLoc_end = 99412579
| Mm_Uniprot = Q3UQD4
}}
}}
'''Aquaporin 2 (collecting duct)''', also known as '''AQP2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant, and recessive forms of nephrogenic diabetes insipidus.<ref>{{cite web | title = Entrez Gene: AQP2 aquaporin 2 (collecting duct)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=359| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bichet DG |title=Nephrogenic diabetes insipidus. |journal=Advances in chronic kidney disease |volume=13 |issue= 2 |pages= 96-104 |year= 2006 |pmid= 16580609 |doi= 10.1053/j.ackd.2006.01.006 }}
*{{cite journal | author=Robben JH, Knoers NV, Deen PM |title=Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus. |journal=Am. J. Physiol. Renal Physiol. |volume=291 |issue= 2 |pages= F257-70 |year= 2006 |pmid= 16825342 |doi= 10.1152/ajprenal.00491.2005 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CACNA1C... {November 7, 2007 12:43:34 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CACNA1C image.jpg {November 7, 2007 12:43:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:44:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CACNA1C_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2be6.
| PDB = {{PDB2|2be6}}
| Name = Calcium channel, voltage-dependent, L type, alpha 1C subunit
| HGNCid = 1390
| Symbol = CACNA1C
| AltSymbols =; CACH2; CACN2; CACNL1A1; CCHL1A1; CaV1.2; MGC120730; TS
| OMIM = 114205
| ECnumber =
| Homologene = 55484
| MGIid = 103013
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005245 |text = voltage-gated calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component = {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}} {{GNF_GO|id=GO:0014069 |text = postsynaptic density}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 775
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000710
| Hs_RefseqmRNA = NM_000719
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12288
| Mm_Ensembl = ENSMUSG00000051331
| Mm_RefseqmRNA = NM_009781
| Mm_RefseqProtein = NP_033911
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 118557938
| Mm_GenLoc_end = 119023135
| Mm_Uniprot = Q0PCR4
}}
}}
'''Calcium channel, voltage-dependent, L type, alpha 1C subunit''', also known as '''CACNA1C''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Many alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref>{{cite web | title = Entrez Gene: CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=775| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J |title=International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 411-25 |year= 2006 |pmid= 16382099 |doi= 10.1124/pr.57.4.5 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCR7... {November 7, 2007 12:45:18 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:45:57 PM PST}
- CREATED: Created new protein page: CCR7 {November 7, 2007 12:46:04 PM PST}
- INFO: Beginning work on CHGA... {November 7, 2007 12:44:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:45:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chromogranin A (parathyroid secretory protein 1)
| HGNCid = 1929
| Symbol = CHGA
| AltSymbols =; CGA
| OMIM = 118910
| ECnumber =
| Homologene = 976
| MGIid = 88394
| GeneAtlas_image1 = PBB_GE_CHGA_204697_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}}
| Process = {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1113
| Hs_Ensembl = ENSG00000100604
| Hs_RefseqProtein = NP_001266
| Hs_RefseqmRNA = NM_001275
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 92459245
| Hs_GenLoc_end = 92471389
| Hs_Uniprot = P10645
| Mm_EntrezGene = 12652
| Mm_Ensembl = ENSMUSG00000021194
| Mm_RefseqmRNA = NM_007693
| Mm_RefseqProtein = NP_031719
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 102956019
| Mm_GenLoc_end = 102966077
| Mm_Uniprot = Q3UN28
}}
}}
'''Chromogranin A (parathyroid secretory protein 1)''', also known as '''CHGA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.<ref>{{cite web | title = Entrez Gene: CHGA chromogranin A (parathyroid secretory protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1113| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hendy GN, Bevan S, Mattei MG, Mouland AJ |title=Chromogranin A. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=18 |issue= 1 |pages= 47-65 |year= 1995 |pmid= 7768066 |doi= }}
*{{cite journal | author=Iacangelo AL, Eiden LE |title=Chromogranin A: current status as a precursor for bioactive peptides and a granulogenic/sorting factor in the regulated secretory pathway. |journal=Regul. Pept. |volume=58 |issue= 3 |pages= 65-88 |year= 1996 |pmid= 8577930 |doi= }}
*{{cite journal | author=Curry WJ, Barkatullah SC, Johansson AN, ''et al.'' |title=WE-14, a chromogranin a-derived neuropeptide. |journal=Ann. N. Y. Acad. Sci. |volume=971 |issue= |pages= 311-6 |year= 2002 |pmid= 12438141 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COPS5... {November 7, 2007 1:04:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:06:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
| HGNCid = 2240
| Symbol = COPS5
| AltSymbols =; CSN5; JAB1; MGC3149; MOV-34; SGN5
| OMIM = 604850
| ECnumber =
| Homologene = 55992
| MGIid = 1349415
| GeneAtlas_image1 = PBB_GE_COPS5_201652_at_tn.png
| GeneAtlas_image2 = PBB_GE_COPS5_gnf1h08492_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005852 |text = eukaryotic translation initiation factor 3 complex}} {{GNF_GO|id=GO:0008180 |text = signalosome}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006412 |text = translation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10987
| Hs_Ensembl = ENSG00000121022
| Hs_RefseqProtein = NP_006828
| Hs_RefseqmRNA = NM_006837
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 68117871
| Hs_GenLoc_end = 68136785
| Hs_Uniprot = Q92905
| Mm_EntrezGene = 26754
| Mm_Ensembl = ENSMUSG00000025917
| Mm_RefseqmRNA = NM_013715
| Mm_RefseqProtein = NP_038743
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 10009816
| Mm_GenLoc_end = 10023160
| Mm_Uniprot = Q3V0K7
}}
}}
'''COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)''', also known as '''COPS5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.<ref>{{cite web | title = Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10987| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029-33 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSF1R... {November 7, 2007 12:46:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:46:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog
| HGNCid = 2433
| Symbol = CSF1R
| AltSymbols =; C-FMS; CD115; CSFR; FIM2; FMS
| OMIM = 164770
| ECnumber =
| Homologene = 3817
| MGIid = 1339758
| GeneAtlas_image1 = PBB_GE_CSF1R_203104_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005011 |text = macrophage colony stimulating factor receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1436
| Hs_Ensembl = ENSG00000182578
| Hs_RefseqProtein = NP_005202
| Hs_RefseqmRNA = NM_005211
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 149413051
| Hs_GenLoc_end = 149473128
| Hs_Uniprot = P07333
| Mm_EntrezGene = 12978
| Mm_Ensembl = ENSMUSG00000024621
| Mm_RefseqmRNA = NM_001037859
| Mm_RefseqProtein = NP_001032948
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 61230941
| Mm_GenLoc_end = 61256506
| Mm_Uniprot = Q0P635
}}
}}
'''Colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog''', also known as '''CSF1R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.<ref>{{cite web | title = Entrez Gene: CSF1R colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1436| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rettenmier CW, Roussel MF, Sherr CJ |title=The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand. |journal=J. Cell Sci. Suppl. |volume=9 |issue= |pages= 27-44 |year= 1989 |pmid= 2978516 |doi= }}
*{{cite journal | author=Stanley ER, Berg KL, Einstein DB, ''et al.'' |title=Biology and action of colony--stimulating factor-1. |journal=Mol. Reprod. Dev. |volume=46 |issue= 1 |pages= 4-10 |year= 1997 |pmid= 8981357 |doi= 10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EWSR1... {November 7, 2007 12:46:45 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EWSR1 image.jpg {November 7, 2007 12:47:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:47:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EWSR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cpe.
| PDB = {{PDB2|2cpe}}
| Name = Ewing sarcoma breakpoint region 1
| HGNCid = 3508
| Symbol = EWSR1
| AltSymbols =; EWS
| OMIM = 133450
| ECnumber =
| Homologene = 22438
| MGIid = 99960
| GeneAtlas_image1 = PBB_GE_EWSR1_210012_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2130
| Hs_Ensembl = ENSG00000182944
| Hs_RefseqProtein = NP_005234
| Hs_RefseqmRNA = NM_005243
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 27994283
| Hs_GenLoc_end = 28026504
| Hs_Uniprot = Q01844
| Mm_EntrezGene = 14030
| Mm_Ensembl = ENSMUSG00000009079
| Mm_RefseqmRNA = XM_988357
| Mm_RefseqProtein = XP_993451
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 4969692
| Mm_GenLoc_end = 4999269
| Mm_Uniprot = Q9CRS5
}}
}}
'''Ewing sarcoma breakpoint region 1''', also known as '''EWSR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a putative RNA binding protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in two products.<ref>{{cite web | title = Entrez Gene: EWSR1 Ewing sarcoma breakpoint region 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2130| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ban J, Siligan C, Kreppel M, ''et al.'' |title=EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage. |journal=Adv. Exp. Med. Biol. |volume=587 |issue= |pages= 41-52 |year= 2007 |pmid= 17163154 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GDNF... {November 7, 2007 12:47:28 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GDNF image.jpg {November 7, 2007 12:48:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:48:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GDNF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1agq.
| PDB = {{PDB2|1agq}}
| Name = Glial cell derived neurotrophic factor
| HGNCid = 4232
| Symbol = GDNF
| AltSymbols =; ATF1; ATF2; HFB1-GDNF
| OMIM = 600837
| ECnumber =
| Homologene = 433
| MGIid = 107430
| GeneAtlas_image1 = PBB_GE_GDNF_221359_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0001657 |text = ureteric bud development}} {{GNF_GO|id=GO:0001755 |text = neural crest cell migration}} {{GNF_GO|id=GO:0001759 |text = induction of an organ}} {{GNF_GO|id=GO:0001941 |text = postsynaptic membrane organization}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0030432 |text = peristalsis}} {{GNF_GO|id=GO:0031175 |text = neurite development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2668
| Hs_Ensembl = ENSG00000168621
| Hs_RefseqProtein = NP_000505
| Hs_RefseqmRNA = NM_000514
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 37848536
| Hs_GenLoc_end = 37875539
| Hs_Uniprot = P39905
| Mm_EntrezGene = 14573
| Mm_Ensembl = ENSMUSG00000022144
| Mm_RefseqmRNA = NM_010275
| Mm_RefseqProtein = NP_034405
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 7758226
| Mm_GenLoc_end = 7784790
| Mm_Uniprot = Q6LEL9
}}
}}
'''Glial cell derived neurotrophic factor''', also known as '''GDNF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.<ref>{{cite web | title = Entrez Gene: GDNF glial cell derived neurotrophic factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2668| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hofstra RM, Osinga J, Buys CH |title=Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 4 |pages= 180-5 |year= 1998 |pmid= 9359036 |doi= }}
*{{cite journal | author=Martucciello G, Ceccherini I, Lerone M, Jasonni V |title=Pathogenesis of Hirschsprung's disease. |journal=J. Pediatr. Surg. |volume=35 |issue= 7 |pages= 1017-25 |year= 2000 |pmid= 10917288 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IFNGR1... {November 7, 2007 12:48:20 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IFNGR1 image.jpg {November 7, 2007 12:49:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:49:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IFNGR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fg9.
| PDB = {{PDB2|1fg9}}, {{PDB2|1fyh}}, {{PDB2|1jrh}}
| Name = Interferon gamma receptor 1
| HGNCid = 5439
| Symbol = IFNGR1
| AltSymbols =; CD119; FLJ45734; IFNGR
| OMIM = 107470
| ECnumber =
| Homologene = 359
| MGIid = 107655
| GeneAtlas_image1 = PBB_GE_IFNGR1_202727_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IFNGR1_211676_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004906 |text = interferon-gamma receptor activity}} {{GNF_GO|id=GO:0019955 |text = cytokine binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3459
| Hs_Ensembl = ENSG00000027697
| Hs_RefseqProtein = NP_000407
| Hs_RefseqmRNA = NM_000416
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 137560314
| Hs_GenLoc_end = 137582279
| Hs_Uniprot = P15260
| Mm_EntrezGene = 15979
| Mm_Ensembl = ENSMUSG00000020009
| Mm_RefseqmRNA = NM_010511
| Mm_RefseqProtein = NP_034641
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 19281386
| Mm_GenLoc_end = 19299641
| Mm_Uniprot = Q3TW49
}}
}}
'''Interferon gamma receptor 1''', also known as '''IFNGR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = IFNGR1 encodes the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor. IFNGR2 encodes the non-ligand-binding partner of the heterodimeric receptor.<ref>{{cite web | title = Entrez Gene: IFNGR1 interferon gamma receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3459| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Samuel CE |title=Antiviral actions of interferons. |journal=Clin. Microbiol. Rev. |volume=14 |issue= 4 |pages= 778-809, table of contents |year= 2002 |pmid= 11585785 |doi= 10.1128/CMR.14.4.778-809.2001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LCAT... {November 7, 2007 12:50:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:50:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Lecithin-cholesterol acyltransferase
| HGNCid = 6522
| Symbol = LCAT
| AltSymbols =;
| OMIM = 606967
| ECnumber =
| Homologene = 68042
| MGIid = 96755
| Function = {{GNF_GO|id=GO:0004607 |text = phosphatidylcholine-sterol O-acyltransferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}} {{GNF_GO|id=GO:0018350 |text = protein amino acid esterification}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3931
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000220
| Hs_RefseqmRNA = NM_000229
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16816
| Mm_Ensembl = ENSMUSG00000035237
| Mm_RefseqmRNA = NM_008490
| Mm_RefseqProtein = NP_032516
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 108828681
| Mm_GenLoc_end = 108832511
| Mm_Uniprot = Q791M3
}}
}}
'''Lecithin-cholesterol acyltransferase''', also known as '''LCAT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.<ref>{{cite web | title = Entrez Gene: LCAT lecithin-cholesterol acyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3931| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kuivenhoven JA, Pritchard H, Hill J, ''et al.'' |title=The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes. |journal=J. Lipid Res. |volume=38 |issue= 2 |pages= 191-205 |year= 1997 |pmid= 9162740 |doi= }}
*{{cite journal | author=de Vries R, Borggreve SE, Dullaart RP |title=Role of lipases, lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus. |journal=Clin. Lab. |volume=49 |issue= 11-12 |pages= 601-13 |year= 2004 |pmid= 14651331 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PAPPA... {November 7, 2007 12:50:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:51:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pregnancy-associated plasma protein A, pappalysin 1
| HGNCid = 8602
| Symbol = PAPPA
| AltSymbols =; PAPA; ASBABP2; DIPLA1; IGFBP-4ase; PAPP-A; PAPPA1
| OMIM = 176385
| ECnumber =
| Homologene = 31097
| MGIid = 97479
| GeneAtlas_image1 = PBB_GE_PAPPA_201981_at_tn.png
| GeneAtlas_image2 = PBB_GE_PAPPA_201982_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5069
| Hs_Ensembl = ENSG00000182752
| Hs_RefseqProtein = NP_002572
| Hs_RefseqmRNA = NM_002581
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 117955892
| Hs_GenLoc_end = 118204420
| Hs_Uniprot = Q13219
| Mm_EntrezGene = 18491
| Mm_Ensembl = ENSMUSG00000028370
| Mm_RefseqmRNA = NM_021362
| Mm_RefseqProtein = NP_067337
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 64610535
| Mm_GenLoc_end = 64843870
| Mm_Uniprot = Q8R4K8
}}
}}
'''Pregnancy-associated plasma protein A, pappalysin 1''', also known as '''PAPPA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.<ref>{{cite web | title = Entrez Gene: PAPPA pregnancy-associated plasma protein A, pappalysin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5069| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PLD1... {November 7, 2007 12:51:37 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:53:46 PM PST}
- CREATED: Created new protein page: PLD1 {November 7, 2007 12:53:53 PM PST}
- INFO: Beginning work on POLB... {November 7, 2007 12:53:53 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein POLB image.jpg {November 7, 2007 12:54:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:54:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_POLB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bno.
| PDB = {{PDB2|1bno}}, {{PDB2|1bnp}}, {{PDB2|1bpb}}, {{PDB2|1bpd}}, {{PDB2|1bpe}}, {{PDB2|1bpx}}, {{PDB2|1bpy}}, {{PDB2|1bpz}}, {{PDB2|1dk2}}, {{PDB2|1dk3}}, {{PDB2|1huo}}, {{PDB2|1huz}}, {{PDB2|1jn3}}, {{PDB2|1mq2}}, {{PDB2|1mq3}}, {{PDB2|1nom}}, {{PDB2|1rpl}}, {{PDB2|1tv9}}, {{PDB2|1tva}}, {{PDB2|1zjm}}, {{PDB2|1zjn}}, {{PDB2|1zqa}}, {{PDB2|1zqb}}, {{PDB2|1zqc}}, {{PDB2|1zqd}}, {{PDB2|1zqe}}, {{PDB2|1zqf}}, {{PDB2|1zqg}}, {{PDB2|1zqh}}, {{PDB2|1zqi}}, {{PDB2|1zqj}}, {{PDB2|1zqk}}, {{PDB2|1zql}}, {{PDB2|1zqm}}, {{PDB2|1zqn}}, {{PDB2|1zqo}}, {{PDB2|1zqp}}, {{PDB2|1zqq}}, {{PDB2|1zqr}}, {{PDB2|1zqs}}, {{PDB2|1zqt}}, {{PDB2|1zqu}}, {{PDB2|1zqv}}, {{PDB2|1zqw}}, {{PDB2|1zqx}}, {{PDB2|1zqy}}, {{PDB2|1zqz}}, {{PDB2|2bpc}}, {{PDB2|2bpf}}, {{PDB2|2bpg}}, {{PDB2|2fmp}}, {{PDB2|2fmq}}, {{PDB2|2fms}}, {{PDB2|2i9g}}, {{PDB2|2iso}}, {{PDB2|2isp}}, {{PDB2|2p66}}, {{PDB2|7ice}}, {{PDB2|7icf}}, {{PDB2|7icg}}, {{PDB2|7ich}}, {{PDB2|7ici}}, {{PDB2|7icj}}, {{PDB2|7ick}}, {{PDB2|7icl}}, {{PDB2|7icm}}, {{PDB2|7icn}}, {{PDB2|7ico}}, {{PDB2|7icp}}, {{PDB2|7icq}}, {{PDB2|7icr}}, {{PDB2|7ics}}, {{PDB2|7ict}}, {{PDB2|7icu}}, {{PDB2|7icv}}, {{PDB2|8ica}}, {{PDB2|8icb}}, {{PDB2|8icc}}, {{PDB2|8ice}}, {{PDB2|8icf}}, {{PDB2|8icg}}, {{PDB2|8ich}}, {{PDB2|8ici}}, {{PDB2|8icj}}, {{PDB2|8ick}}, {{PDB2|8icl}}, {{PDB2|8icm}}, {{PDB2|8icn}}, {{PDB2|8ico}}, {{PDB2|8icp}}, {{PDB2|8icq}}, {{PDB2|8icr}}, {{PDB2|8ics}}, {{PDB2|8ict}}, {{PDB2|8icu}}, {{PDB2|8icv}}, {{PDB2|8icw}}, {{PDB2|8icx}}, {{PDB2|8icy}}, {{PDB2|8icz}}, {{PDB2|9ica}}, {{PDB2|9icb}}, {{PDB2|9icc}}, {{PDB2|9ice}}, {{PDB2|9icf}}, {{PDB2|9icg}}, {{PDB2|9ich}}, {{PDB2|9ici}}, {{PDB2|9icj}}, {{PDB2|9ick}}, {{PDB2|9icl}}, {{PDB2|9icm}}, {{PDB2|9icn}}, {{PDB2|9ico}}, {{PDB2|9icp}}, {{PDB2|9icq}}, {{PDB2|9icr}}, {{PDB2|9ics}}, {{PDB2|9ict}}, {{PDB2|9icu}}, {{PDB2|9icv}}, {{PDB2|9icw}}, {{PDB2|9icx}}, {{PDB2|9icy}}
| Name = Polymerase (DNA directed), beta
| HGNCid = 9174
| Symbol = POLB
| AltSymbols =; MGC125976
| OMIM = 174760
| ECnumber =
| Homologene = 2013
| MGIid = 97740
| GeneAtlas_image1 = PBB_GE_POLB_203616_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003890 |text = beta DNA polymerase activity}} {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005876 |text = spindle microtubule}}
| Process = {{GNF_GO|id=GO:0006261 |text = DNA-dependent DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5423
| Hs_Ensembl = ENSG00000070501
| Hs_RefseqProtein = NP_002681
| Hs_RefseqmRNA = NM_002690
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 42315131
| Hs_GenLoc_end = 42348482
| Hs_Uniprot = P06746
| Mm_EntrezGene = 18970
| Mm_Ensembl = ENSMUSG00000031536
| Mm_RefseqmRNA = NM_011130
| Mm_RefseqProtein = NP_035260
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 24093675
| Mm_GenLoc_end = 24118966
| Mm_Uniprot = Q62085
}}
}}
'''Polymerase (DNA directed), beta''', also known as '''POLB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. Also see POLA (MIM 312040).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: POLB polymerase (DNA directed), beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5423| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on POLR2I... {November 7, 2007 12:54:38 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:55:13 PM PST}
- CREATED: Created new protein page: POLR2I {November 7, 2007 12:55:21 PM PST}
- INFO: Beginning work on PRKCI... {November 7, 2007 12:55:21 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PRKCI image.jpg {November 7, 2007 12:56:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:56:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKCI_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vd2.
| PDB = {{PDB2|1vd2}}, {{PDB2|1wmh}}, {{PDB2|1zrz}}
| Name = Protein kinase C, iota
| HGNCid = 9404
| Symbol = PRKCI
| AltSymbols =; DXS1179E; MGC26534; PKCI; nPKC-iota
| OMIM = 600539
| ECnumber =
| Homologene = 37667
| MGIid = 99260
| GeneAtlas_image1 = PBB_GE_PRKCI_209678_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKCI_209677_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRKCI_213518_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004700 |text = atypical protein kinase C activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000133 |text = polarisome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0045177 |text = apical part of cell}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006612 |text = protein targeting to membrane}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007015 |text = actin filament organization}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016044 |text = membrane organization and biogenesis}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}} {{GNF_GO|id=GO:0035089 |text = establishment of apical/basal cell polarity}} {{GNF_GO|id=GO:0042462 |text = eye photoreceptor cell development}} {{GNF_GO|id=GO:0045197 |text = establishment and/or maintenance of epithelial cell polarity}} {{GNF_GO|id=GO:0045216 |text = intercellular junction assembly and maintenance}} {{GNF_GO|id=GO:0046903 |text = secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5584
| Hs_Ensembl = ENSG00000163558
| Hs_RefseqProtein = NP_002731
| Hs_RefseqmRNA = NM_002740
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 171422919
| Hs_GenLoc_end = 171506458
| Hs_Uniprot = P41743
| Mm_EntrezGene = 18759
| Mm_Ensembl = ENSMUSG00000037643
| Mm_RefseqmRNA = NM_008857
| Mm_RefseqProtein = NP_032883
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 31186625
| Mm_GenLoc_end = 31243615
| Mm_Uniprot = Q3TJJ5
}}
}}
'''Protein kinase C, iota''', also known as '''PRKCI''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.<ref>{{cite web | title = Entrez Gene: PRKCI protein kinase C, iota| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5584| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Suzuki A, Akimoto K, Ohno S |title=Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. |journal=J. Biochem. |volume=133 |issue= 1 |pages= 9-16 |year= 2003 |pmid= 12761193 |doi= }}
*{{cite journal | author=Fields AP, Regala RP |title=Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. |journal=Pharmacol. Res. |volume=55 |issue= 6 |pages= 487-97 |year= 2007 |pmid= 17570678 |doi= 10.1016/j.phrs.2007.04.015 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRKD1... {November 7, 2007 12:56:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:57:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein kinase D1
| HGNCid = 9407
| Symbol = PRKD1
| AltSymbols =; PKC-MU; PKCM; PKD; PRKCM
| OMIM = 605435
| ECnumber =
| Homologene = 55680
| MGIid = 99879
| GeneAtlas_image1 = PBB_GE_PRKD1_205880_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004700 |text = atypical protein kinase C activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5587
| Hs_Ensembl = ENSG00000184304
| Hs_RefseqProtein = NP_002733
| Hs_RefseqmRNA = NM_002742
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 29116195
| Hs_GenLoc_end = 29466469
| Hs_Uniprot = Q15139
| Mm_EntrezGene = 18760
| Mm_Ensembl = ENSMUSG00000002688
| Mm_RefseqmRNA = NM_008858
| Mm_RefseqProtein = NP_032884
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 51217854
| Mm_GenLoc_end = 51571105
| Mm_Uniprot = Q62101
}}
}}
'''Protein kinase D1''', also known as '''PRKD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the protein kinase C (PKC) family function in many extracellular receptor-mediated signal transduction pathways. See PRKCA (MIM 176960) for further background information. The PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PRKD1 protein kinase D1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5587| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Van Lint J, Rykx A, Maeda Y, ''et al.'' |title=Protein kinase D: an intracellular traffic regulator on the move. |journal=Trends Cell Biol. |volume=12 |issue= 4 |pages= 193-200 |year= 2002 |pmid= 11978539 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RYR2... {November 7, 2007 12:57:35 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:58:02 PM PST}
- CREATED: Created new protein page: RYR2 {November 7, 2007 12:58:09 PM PST}
- INFO: Beginning work on SFRS2... {November 7, 2007 12:58:09 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:59:35 PM PST}
- CREATED: Created new protein page: SFRS2 {November 7, 2007 1:01:01 PM PST}
- INFO: Beginning work on SLC3A2... {November 7, 2007 1:01:01 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SLC3A2 image.jpg {November 7, 2007 1:01:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:02:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SLC3A2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dh2.
| PDB = {{PDB2|2dh2}}, {{PDB2|2dh3}}
| Name = Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
| HGNCid = 11026
| Symbol = SLC3A2
| AltSymbols =; 4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1; NACAE
| OMIM = 158070
| ECnumber =
| Homologene = 1795
| MGIid = 96955
| GeneAtlas_image1 = PBB_GE_SLC3A2_200924_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0005432 |text = calcium:sodium antiporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015171 |text = amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0043169 |text = cation binding}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006865 |text = amino acid transport}} {{GNF_GO|id=GO:0015827 |text = tryptophan transport}} {{GNF_GO|id=GO:0016049 |text = cell growth}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6520
| Hs_Ensembl = ENSG00000168003
| Hs_RefseqProtein = NP_001012679
| Hs_RefseqmRNA = NM_001012661
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 62380094
| Hs_GenLoc_end = 62412928
| Hs_Uniprot = P08195
| Mm_EntrezGene = 17254
| Mm_Ensembl = ENSMUSG00000010095
| Mm_RefseqmRNA = NM_008577
| Mm_RefseqProtein = NP_032603
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 8773927
| Mm_GenLoc_end = 8780921
| Mm_Uniprot = Q3TIP1
}}
}}
'''Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2''', also known as '''SLC3A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6520| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC9A1... {November 7, 2007 1:02:04 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SLC9A1 image.jpg {November 7, 2007 1:02:37 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:02:51 PM PST}
- CREATED: Created new protein page: SLC9A1 {November 7, 2007 1:02:59 PM PST}
- INFO: Beginning work on STMN1... {November 7, 2007 12:49:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:50:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Stathmin 1/oncoprotein 18
| HGNCid = 6510
| Symbol = STMN1
| AltSymbols =; LAP18; Lag; OP18; PP17; PP19; PR22; SMN
| OMIM = 151442
| ECnumber =
| Homologene = 4063
| MGIid = 96739
| GeneAtlas_image1 = PBB_GE_STMN1_200783_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015631 |text = tubulin binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005874 |text = microtubule}}
| Process = {{GNF_GO|id=GO:0007019 |text = microtubule depolymerization}} {{GNF_GO|id=GO:0007052 |text = mitotic spindle organization and biogenesis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3925
| Hs_Ensembl = ENSG00000117632
| Hs_RefseqProtein = NP_005554
| Hs_RefseqmRNA = NM_005563
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 26099180
| Hs_GenLoc_end = 26105955
| Hs_Uniprot = P16949
| Mm_EntrezGene = 16765
| Mm_Ensembl = ENSMUSG00000028832
| Mm_RefseqmRNA = NM_019641
| Mm_RefseqProtein = NP_062615
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 133740475
| Mm_GenLoc_end = 133745914
| Mm_Uniprot = Q545B6
}}
}}
'''Stathmin 1/oncoprotein 18''', also known as '''STMN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified.<ref>{{cite web | title = Entrez Gene: STMN1 stathmin 1/oncoprotein 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3925| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sobel A |title=Stathmin: a relay phosphoprotein for multiple signal transduction? |journal=Trends Biochem. Sci. |volume=16 |issue= 8 |pages= 301-5 |year= 1991 |pmid= 1957351 |doi= }}
*{{cite journal | author=Steinmetz MO |title=Structure and thermodynamics of the tubulin-stathmin interaction. |journal=J. Struct. Biol. |volume=158 |issue= 2 |pages= 137-47 |year= 2007 |pmid= 17029844 |doi= 10.1016/j.jsb.2006.07.018 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TG... {November 7, 2007 1:02:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:03:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thyroglobulin
| HGNCid = 11764
| Symbol = TG
| AltSymbols =; AITD3; TGN
| OMIM = 188450
| ECnumber =
| Homologene = 2430
| MGIid = 98733
| Function = {{GNF_GO|id=GO:0004759 |text = carboxylesterase activity}} {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006590 |text = thyroid hormone generation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042446 |text = hormone biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7038
| Hs_Ensembl = ENSG00000042832
| Hs_RefseqProtein = NP_003226
| Hs_RefseqmRNA = NM_003235
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 133948387
| Hs_GenLoc_end = 134216325
| Hs_Uniprot = P01266
| Mm_EntrezGene = 21819
| Mm_Ensembl = ENSMUSG00000053469
| Mm_RefseqmRNA = NM_009375
| Mm_RefseqProtein = NP_033401
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 66500422
| Mm_GenLoc_end = 66680286
| Mm_Uniprot = Q2NKY1
}}
}}
'''Thyroglobulin''', also known as '''TG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mazzaferri EL, Robbins RJ, Spencer CA, ''et al.'' |title=A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 4 |pages= 1433-41 |year= 2003 |pmid= 12679418 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFRSF8... {November 7, 2007 12:44:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:44:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor necrosis factor receptor superfamily, member 8
| HGNCid = 11923
| Symbol = TNFRSF8
| AltSymbols =; CD30; D1S166E; KI-1
| OMIM = 153243
| ECnumber =
| Homologene = 949
| MGIid = 99908
| GeneAtlas_image1 = PBB_GE_TNFRSF8_206729_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 943
| Hs_Ensembl = ENSG00000120949
| Hs_RefseqProtein = NP_001234
| Hs_RefseqmRNA = NM_001243
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 12046021
| Hs_GenLoc_end = 12126851
| Hs_Uniprot = P28908
| Mm_EntrezGene = 21941
| Mm_Ensembl = ENSMUSG00000028602
| Mm_RefseqmRNA = NM_009401
| Mm_RefseqProtein = NP_033427
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 144535663
| Mm_GenLoc_end = 144581834
| Mm_Uniprot = Q60846
}}
}}
'''Tumor necrosis factor receptor superfamily, member 8''', also known as '''TNFRSF8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=943| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schneider C, Hübinger G |title=Pleiotropic signal transduction mediated by human CD30: a member of the tumor necrosis factor receptor (TNFR) family. |journal=Leuk. Lymphoma |volume=43 |issue= 7 |pages= 1355-66 |year= 2003 |pmid= 12389614 |doi= }}
*{{cite journal | author=Horie R, Higashihara M, Watanabe T |title=Hodgkin's lymphoma and CD30 signal transduction. |journal=Int. J. Hematol. |volume=77 |issue= 1 |pages= 37-47 |year= 2003 |pmid= 12568298 |doi= }}
*{{cite journal | author=Tarkowski M |title=Expression and a role of CD30 in regulation of T-cell activity. |journal=Curr. Opin. Hematol. |volume=10 |issue= 4 |pages= 267-71 |year= 2004 |pmid= 12799531 |doi= }}
*{{cite journal | author=Granados S, Hwang ST |title=Roles for CD30 in the biology and treatment of CD30 lymphoproliferative diseases. |journal=J. Invest. Dermatol. |volume=122 |issue= 6 |pages= 1345-7 |year= 2004 |pmid= 15175022 |doi= 10.1111/j.0022-202X.2004.22616.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ZBTB16... {November 7, 2007 1:03:14 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ZBTB16 image.jpg {November 7, 2007 1:03:47 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:03:59 PM PST}
- CREATED: Created new protein page: ZBTB16 {November 7, 2007 1:04:07 PM PST}
end log.
