Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 10:31, 7 November 2007 (UTC)[edit]
Proteins without matches (14)[edit]
Proteins with a High Potential Match (11)[edit]
Created (8)[edit]
Manual Inspection (Page not found) (17)[edit]
Protein Status Grid - Date: 10:31, 7 November 2007 (UTC)[edit]
Vebose Log - Date: 10:31, 7 November 2007 (UTC)[edit]
- INFO: Beginning work on ABCC8... {November 7, 2007 2:21:04 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:21:54 AM PST}
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{{PBB_Controls
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family C (CFTR/MRP), member 8
| HGNCid = 59
| Symbol = ABCC8
| AltSymbols =; PHHI; MRP8; ABC36; HHF1; HI; HRINS; SUR; SUR1; TNDM2
| OMIM = 600509
| ECnumber =
| Homologene = 68048
| MGIid = 1352629
| GeneAtlas_image1 = PBB_GE_ABCC8_210246_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008281 |text = sulfonylurea receptor activity}} {{GNF_GO|id=GO:0015079 |text = potassium ion transmembrane transporter activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6833
| Hs_Ensembl = ENSG00000006071
| Hs_RefseqProtein = NP_000343
| Hs_RefseqmRNA = NM_000352
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 17371009
| Hs_GenLoc_end = 17455025
| Hs_Uniprot = Q09428
| Mm_EntrezGene = 20927
| Mm_Ensembl = ENSMUSG00000040136
| Mm_RefseqmRNA = NM_011510
| Mm_RefseqProtein = NP_035640
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 45972565
| Mm_GenLoc_end = 46048075
| Mm_Uniprot =
}}
}}
'''ATP-binding cassette, sub-family C (CFTR/MRP), member 8''', also known as '''ABCC8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.<ref>{{cite web | title = Entrez Gene: ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6833| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Aguilar-Bryan L, Bryan J |title=Molecular biology of adenosine triphosphate-sensitive potassium channels. |journal=Endocr. Rev. |volume=20 |issue= 2 |pages= 101-35 |year= 1999 |pmid= 10204114 |doi= }}
*{{cite journal | author=Meissner T, Beinbrech B, Mayatepek E |title=Congenital hyperinsulinism: molecular basis of a heterogeneous disease. |journal=Hum. Mutat. |volume=13 |issue= 5 |pages= 351-61 |year= 1999 |pmid= 10338089 |doi= 10.1002/(SICI)1098-1004(1999)13:5<351::AID-HUMU3>3.0.CO;2-R }}
*{{cite journal | author=Gloyn AL, Siddiqui J, Ellard S |title=Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism. |journal=Hum. Mutat. |volume=27 |issue= 3 |pages= 220-31 |year= 2006 |pmid= 16416420 |doi= 10.1002/humu.20292 }}
*{{cite journal | author=Bryan J, Muñoz A, Zhang X, ''et al.'' |title=ABCC8 and ABCC9: ABC transporters that regulate K+ channels. |journal=Pflugers Arch. |volume=453 |issue= 5 |pages= 703-18 |year= 2007 |pmid= 16897043 |doi= 10.1007/s00424-006-0116-z }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AQP1... {November 7, 2007 2:02:42 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AQP1 image.jpg {November 7, 2007 2:03:42 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:03:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AQP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fqy.
| PDB = {{PDB2|1fqy}}, {{PDB2|1h6i}}, {{PDB2|1ih5}}, {{PDB2|1j4n}}
| Name = Aquaporin 1 (Colton blood group)
| HGNCid = 633
| Symbol = AQP1
| AltSymbols =; AQP-CHIP; CHIP28; CO; MGC26324
| OMIM = 107776
| ECnumber =
| Homologene = 68051
| MGIid = 103201
| GeneAtlas_image1 = PBB_GE_AQP1_209047_at_tn.png
| GeneAtlas_image2 = PBB_GE_AQP1_207542_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005372 |text = water transporter activity}} {{GNF_GO|id=GO:0015288 |text = porin activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019867 |text = outer membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0007588 |text = excretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 358
| Hs_Ensembl = ENSG00000106125
| Hs_RefseqProtein = NP_932766
| Hs_RefseqmRNA = NM_198098
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 30917993
| Hs_GenLoc_end = 30931656
| Hs_Uniprot = P29972
| Mm_EntrezGene = 11826
| Mm_Ensembl = ENSMUSG00000004655
| Mm_RefseqmRNA = NM_007472
| Mm_RefseqProtein = NP_031498
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 55266010
| Mm_GenLoc_end = 55278133
| Mm_Uniprot = Q3TLW5
}}
}}
'''Aquaporin 1 (Colton blood group)''', also known as '''AQP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.<ref>{{cite web | title = Entrez Gene: AQP1 aquaporin 1 (Colton blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=358| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Knepper MA |title=The aquaporin family of molecular water channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6255-8 |year= 1994 |pmid= 7517546 |doi= }}
*{{cite journal | author=Borgnia M, Nielsen S, Engel A, Agre P |title=Cellular and molecular biology of the aquaporin water channels. |journal=Annu. Rev. Biochem. |volume=68 |issue= |pages= 425-58 |year= 2000 |pmid= 10872456 |doi= 10.1146/annurev.biochem.68.1.425 }}
*{{cite journal | author=Horster M |title=Embryonic epithelial membrane transporters. |journal=Am. J. Physiol. Renal Physiol. |volume=279 |issue= 6 |pages= F982-96 |year= 2001 |pmid= 11097616 |doi= }}
*{{cite journal | author=Yool AJ, Weinstein AM |title=New roles for old holes: ion channel function in aquaporin-1. |journal=News Physiol. Sci. |volume=17 |issue= |pages= 68-72 |year= 2002 |pmid= 11909995 |doi= }}
*{{cite journal | author=Mitra AK, Ren G, Reddy VS, ''et al.'' |title=The architecture of a water-selective pore in the lipid bilayer visualized by electron crystallography in vitreous ice. |journal=Novartis Found. Symp. |volume=245 |issue= |pages= 33-46; discussion 46-50; 165-8 |year= 2002 |pmid= 12027013 |doi= }}
*{{cite journal | author=Ripoche P, Goossens D, Devuyst O, ''et al.'' |title=Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 117-22 |year= 2006 |pmid= 16574458 |doi= 10.1016/j.tracli.2006.03.004 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AXIN1... {November 7, 2007 2:24:08 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AXIN1 image.jpg {November 7, 2007 2:24:39 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:24:51 AM PST}
- CREATED: Created new protein page: AXIN1 {November 7, 2007 2:25:00 AM PST}
- INFO: Beginning work on BCHE... {November 7, 2007 2:03:57 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BCHE image.jpg {November 7, 2007 2:04:27 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:04:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BCHE_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p0i.
| PDB = {{PDB2|1p0i}}, {{PDB2|1p0m}}, {{PDB2|1p0p}}, {{PDB2|1p0q}}, {{PDB2|1xlu}}, {{PDB2|1xlv}}, {{PDB2|1xlw}}, {{PDB2|2j4c}}
| Name = Butyrylcholinesterase
| HGNCid = 983
| Symbol = BCHE
| AltSymbols =; CHE1; E1
| OMIM = 177400
| ECnumber =
| Homologene = 20065
| MGIid = 894278
| GeneAtlas_image1 = PBB_GE_BCHE_205433_at_tn.png
| Function = {{GNF_GO|id=GO:0001540 |text = beta-amyloid binding}} {{GNF_GO|id=GO:0004104 |text = cholinesterase activity}} {{GNF_GO|id=GO:0004759 |text = carboxylesterase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005641 |text = nuclear envelope lumen}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0050783 |text = cocaine metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 590
| Hs_Ensembl = ENSG00000114200
| Hs_RefseqProtein = NP_000046
| Hs_RefseqmRNA = NM_000055
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 166973387
| Hs_GenLoc_end = 167037944
| Hs_Uniprot = P06276
| Mm_EntrezGene = 12038
| Mm_Ensembl = ENSMUSG00000027792
| Mm_RefseqmRNA = NM_009738
| Mm_RefseqProtein = NP_033868
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 73721734
| Mm_GenLoc_end = 73794168
| Mm_Uniprot = Q499C7
}}
}}
'''Butyrylcholinesterase''', also known as '''BCHE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.<ref>{{cite web | title = Entrez Gene: BCHE butyrylcholinesterase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=590| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lockridge O |title=Structure of human serum cholinesterase. |journal=Bioessays |volume=9 |issue= 4 |pages= 125-8 |year= 1989 |pmid= 3067729 |doi= 10.1002/bies.950090406 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAMK2G... {November 7, 2007 2:04:39 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CAMK2G image.jpg {November 7, 2007 2:05:34 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:05:52 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CAMK2G_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ux0.
| PDB = {{PDB2|2ux0}}
| Name = Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
| HGNCid = 1463
| Symbol = CAMK2G
| AltSymbols =; CAMK; CAMK-II; CAMKG; FLJ16043; MGC26678
| OMIM = 602123
| ECnumber =
| Homologene = 15596
| MGIid = 88259
| GeneAtlas_image1 = PBB_GE_CAMK2G_212669_at_tn.png
| GeneAtlas_image2 = PBB_GE_CAMK2G_212757_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004685 |text = calmodulin-dependent protein kinase activity}} {{GNF_GO|id=GO:0004723 |text = calcium-dependent protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005954 |text = calcium- and calmodulin-dependent protein kinase complex}}
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030073 |text = insulin secretion}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 818
| Hs_Ensembl = ENSG00000148660
| Hs_RefseqProtein = NP_001213
| Hs_RefseqmRNA = NM_001222
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 75242265
| Hs_GenLoc_end = 75304349
| Hs_Uniprot = Q13555
| Mm_EntrezGene = 12325
| Mm_Ensembl = ENSMUSG00000021820
| Mm_RefseqmRNA = XM_980738
| Mm_RefseqProtein = XP_985832
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 19523427
| Mm_GenLoc_end = 19582640
| Mm_Uniprot = Q923T9
}}
}}
'''Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma''', also known as '''CAMK2G''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.<ref>{{cite web | title = Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=818| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hook SS, Means AR |title=Ca(2+)/CaM-dependent kinases: from activation to function. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=41 |issue= |pages= 471-505 |year= 2001 |pmid= 11264466 |doi= 10.1146/annurev.pharmtox.41.1.471 }}
*{{cite journal | author=Yamamoto H |title=[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 3 |pages= 241-7 |year= 2002 |pmid= 11889801 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CASP2... {November 7, 2007 2:05:52 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CASP2 image.jpg {November 7, 2007 2:07:46 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:08:03 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CASP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pyo.
| PDB = {{PDB2|1pyo}}, {{PDB2|2p2c}}
| Name = Caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)
| HGNCid = 1503
| Symbol = CASP2
| AltSymbols =; CASP-2; ICH-1L; ICH-1L/1S; ICH1; NEDD2
| OMIM = 600639
| ECnumber =
| Homologene = 7254
| MGIid = 97295
| GeneAtlas_image1 = PBB_GE_CASP2_34449_at_tn.png
| GeneAtlas_image2 = PBB_GE_CASP2_208050_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CASP2_209811_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0030693 |text = caspase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 835
| Hs_Ensembl = ENSG00000106144
| Hs_RefseqProtein = NP_116764
| Hs_RefseqmRNA = NM_032982
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 142695524
| Hs_GenLoc_end = 142714906
| Hs_Uniprot = P42575
| Mm_EntrezGene = 12366
| Mm_Ensembl = ENSMUSG00000029863
| Mm_RefseqmRNA = NM_007610
| Mm_RefseqProtein = NP_031636
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 42194648
| Mm_GenLoc_end = 42212114
| Mm_Uniprot = P29594
}}
}}
'''Caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)''', also known as '''CASP2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.<ref>{{cite web | title = Entrez Gene: CASP2 caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=835| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD38... {November 7, 2007 2:08:03 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CD38 image.jpg {November 7, 2007 2:08:38 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:08:47 AM PST}
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{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD38_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yh3.
| PDB = {{PDB2|1yh3}}, {{PDB2|1zvm}}, {{PDB2|2ef1}}, {{PDB2|2hct}}, {{PDB2|2i65}}, {{PDB2|2i66}}, {{PDB2|2i67}}, {{PDB2|2o3q}}, {{PDB2|2o3r}}, {{PDB2|2o3s}}, {{PDB2|2o3t}}, {{PDB2|2o3u}}, {{PDB2|2pgj}}, {{PDB2|2pgl}}
| Name = CD38 molecule
| HGNCid = 1667
| Symbol = CD38
| AltSymbols =; T10
| OMIM = 107270
| ECnumber =
| Homologene = 1345
| MGIid = 107474
| GeneAtlas_image1 = PBB_GE_CD38_205692_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003953 |text = NAD+ nucleosidase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0016849 |text = phosphorus-oxygen lyase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 952
| Hs_Ensembl = ENSG00000004468
| Hs_RefseqProtein = NP_001766
| Hs_RefseqmRNA = NM_001775
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 15388999
| Hs_GenLoc_end = 15460167
| Hs_Uniprot = P28907
| Mm_EntrezGene = 12494
| Mm_Ensembl = ENSMUSG00000029084
| Mm_RefseqmRNA = NM_007646
| Mm_RefseqProtein = NP_031672
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 44157098
| Mm_GenLoc_end = 44200622
| Mm_Uniprot = Q3UCS6
}}
}}
'''CD38 molecule''', also known as '''CD38''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.<ref>{{cite web | title = Entrez Gene: CD38 CD38 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=952| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=States DJ, Walseth TF, Lee HC |title=Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38. |journal=Trends Biochem. Sci. |volume=17 |issue= 12 |pages= 495 |year= 1993 |pmid= 1471258 |doi= }}
*{{cite journal | author=Malavasi F, Funaro A, Roggero S, ''et al.'' |title=Human CD38: a glycoprotein in search of a function. |journal=Immunol. Today |volume=15 |issue= 3 |pages= 95-7 |year= 1994 |pmid= 8172650 |doi= }}
*{{cite journal | author=Guse AH |title=Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger. |journal=Cell. Signal. |volume=11 |issue= 5 |pages= 309-16 |year= 1999 |pmid= 10376802 |doi= }}
*{{cite journal | author=Funaro A, Malavasi F |title=Human CD38, a surface receptor, an enzyme, an adhesion molecule and not a simple marker. |journal=J. Biol. Regul. Homeost. Agents |volume=13 |issue= 1 |pages= 54-61 |year= 1999 |pmid= 10432444 |doi= }}
*{{cite journal | author=Mallone R, Perin PC |title=Anti-CD38 autoantibodies in type? diabetes. |journal=Diabetes Metab. Res. Rev. |volume=22 |issue= 4 |pages= 284-94 |year= 2006 |pmid= 16544364 |doi= 10.1002/dmrr.626 }}
*{{cite journal | author=Partidá-Sánchez S, Rivero-Nava L, Shi G, Lund FE |title=CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. |journal=Adv. Exp. Med. Biol. |volume=590 |issue= |pages= 171-83 |year= 2007 |pmid= 17191385 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CGA... {November 7, 2007 2:08:47 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CGA image.jpg {November 7, 2007 2:09:18 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:09:42 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CGA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dz7.
| PDB = {{PDB2|1dz7}}, {{PDB2|1e9j}}, {{PDB2|1fl7}}, {{PDB2|1hcn}}, {{PDB2|1hd4}}, {{PDB2|1hrp}}, {{PDB2|1qfw}}, {{PDB2|1xwd}}
| Name = Glycoprotein hormones, alpha polypeptide
| HGNCid = 1885
| Symbol = CGA
| AltSymbols =; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
| OMIM = 118850
| ECnumber =
| Homologene = 587
| MGIid = 88390
| GeneAtlas_image1 = PBB_GE_CGA_204637_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1081
| Hs_Ensembl = ENSG00000135346
| Hs_RefseqProtein = NP_000726
| Hs_RefseqmRNA = NM_000735
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 87851935
| Hs_GenLoc_end = 87861569
| Hs_Uniprot = P01215
| Mm_EntrezGene = 12640
| Mm_Ensembl = ENSMUSG00000028298
| Mm_RefseqmRNA = NM_009889
| Mm_RefseqProtein = NP_034019
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 35082666
| Mm_GenLoc_end = 35096261
| Mm_Uniprot = P01216
}}
}}
'''Glycoprotein hormones, alpha polypeptide''', also known as '''CGA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.<ref>{{cite web | title = Entrez Gene: CGA glycoprotein hormones, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1081| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Roger M, Lahlou N, Couzinet B, ''et al.'' |title=[Free alpha-subunit glycoprotein hormones: physiological and pathological data] |journal=J. Steroid Biochem. |volume=33 |issue= 4B |pages= 763-9 |year= 1990 |pmid= 2481154 |doi= }}
*{{cite journal | author=Pierce JG |title=Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones. |journal=Endocrinology |volume=89 |issue= 6 |pages= 1331-44 |year= 1972 |pmid= 5002675 |doi= }}
*{{cite journal | author=Kourides IA, Gurr JA, Wolf O |title=The regulation and organization of thyroid stimulating hormone genes. |journal=Recent Prog. Horm. Res. |volume=40 |issue= |pages= 79-120 |year= 1984 |pmid= 6207569 |doi= }}
*{{cite journal | author=Miyoshi I, Kasai N, Hayashizaki Y |title=[Structure and regulation of human thyroid-stimulating hormone (TSH) gene] |journal=Nippon Rinsho |volume=52 |issue= 4 |pages= 940-7 |year= 1994 |pmid= 8196184 |doi= }}
*{{cite journal | author=Barrios-De-Tomasi J, Timossi C, Merchant H, ''et al.'' |title=Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones. |journal=Mol. Cell. Endocrinol. |volume=186 |issue= 2 |pages= 189-98 |year= 2002 |pmid= 11900895 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CLTC... {November 7, 2007 2:09:42 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CLTC image.jpg {November 7, 2007 2:10:21 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:10:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CLTC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b89.
| PDB = {{PDB2|1b89}}, {{PDB2|1bpo}}, {{PDB2|1c9i}}, {{PDB2|1c9l}}, {{PDB2|1utc}}, {{PDB2|1xi4}}, {{PDB2|1xi5}}
| Name = Clathrin, heavy chain (Hc)
| HGNCid = 2092
| Symbol = CLTC
| AltSymbols =; CHC17; CLH-17; CLTCL2; Hc; KIAA0034
| OMIM = 118955
| ECnumber =
| Homologene = 3572
| MGIid = 2388633
| GeneAtlas_image1 = PBB_GE_CLTC_200614_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005905 |text = coated pit}} {{GNF_GO|id=GO:0030125 |text = clathrin vesicle coat}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1213
| Hs_Ensembl = ENSG00000141367
| Hs_RefseqProtein = NP_004850
| Hs_RefseqmRNA = NM_004859
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 55052038
| Hs_GenLoc_end = 55127254
| Hs_Uniprot = Q00610
| Mm_EntrezGene = 67300
| Mm_Ensembl = ENSMUSG00000047126
| Mm_RefseqmRNA = NM_001003908
| Mm_RefseqProtein = NP_001003908
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 86510546
| Mm_GenLoc_end = 86573760
| Mm_Uniprot = Q3TJ98
}}
}}
'''Clathrin, heavy chain (Hc)''', also known as '''CLTC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.<ref>{{cite web | title = Entrez Gene: CLTC clathrin, heavy chain (Hc)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1213| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL18A1... {November 7, 2007 2:27:01 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein COL18A1 image.jpg {November 7, 2007 2:27:51 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:28:05 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COL18A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bnl.
| PDB = {{PDB2|1bnl}}
| Name = Collagen, type XVIII, alpha 1
| HGNCid = 2195
| Symbol = COL18A1
| AltSymbols =; FLJ27325; KNO; MGC74745
| OMIM = 120328
| ECnumber =
| Homologene = 7673
| MGIid = 88451
| GeneAtlas_image1 = PBB_GE_COL18A1_209082_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL18A1_209081_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 80781
| Hs_Ensembl = ENSG00000182871
| Hs_RefseqProtein = NP_085059
| Hs_RefseqmRNA = NM_030582
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 45649516
| Hs_GenLoc_end = 45758061
| Hs_Uniprot = P39060
| Mm_EntrezGene = 12822
| Mm_Ensembl = ENSMUSG00000001435
| Mm_RefseqmRNA = NM_009929
| Mm_RefseqProtein = NP_034059
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 76495895
| Mm_GenLoc_end = 76610217
| Mm_Uniprot = Q61434
}}
}}
'''Collagen, type XVIII, alpha 1''', also known as '''COL18A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: COL18A1 collagen, type XVIII, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80781| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pufe T, Kurz B, Petersen W, ''et al.'' |title=The influence of biomechanical parameters on the expression of VEGF and endostatin in the bone and joint system. |journal=Ann. Anat. |volume=187 |issue= 5-6 |pages= 461-72 |year= 2006 |pmid= 16320826 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CTSG... {November 7, 2007 2:10:40 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CTSG image.jpg {November 7, 2007 2:11:28 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:11:49 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CTSG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1au8.
| PDB = {{PDB2|1au8}}, {{PDB2|1cgh}}, {{PDB2|1kyn}}, {{PDB2|1t32}}
| Name = Cathepsin G
| HGNCid = 2532
| Symbol = CTSG
| AltSymbols =; CG; MGC23078
| OMIM = 116830
| ECnumber =
| Homologene = 20450
| MGIid = 88563
| GeneAtlas_image1 = PBB_GE_CTSG_205653_at_tn.png
| Function = {{GNF_GO|id=GO:0004261 |text = cathepsin G activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005626 |text = insoluble fraction}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1511
| Hs_Ensembl = ENSG00000100448
| Hs_RefseqProtein = NP_001902
| Hs_RefseqmRNA = NM_001911
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 24112564
| Hs_GenLoc_end = 24115306
| Hs_Uniprot = P08311
| Mm_EntrezGene = 13035
| Mm_Ensembl = ENSMUSG00000040314
| Mm_RefseqmRNA = NM_007800
| Mm_RefseqProtein = NP_031826
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 55053952
| Mm_GenLoc_end = 55056645
| Mm_Uniprot = Q059V7
}}
}}
'''Cathepsin G''', also known as '''CTSG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene.<ref>{{cite web | title = Entrez Gene: CTSG cathepsin G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1511| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Shafer WM, Katzif S, Bowers S, ''et al.'' |title=Tailoring an antibacterial peptide of human lysosomal cathepsin G to enhance its broad-spectrum action against antibiotic-resistant bacterial pathogens. |journal=Curr. Pharm. Des. |volume=8 |issue= 9 |pages= 695-702 |year= 2002 |pmid= 11945165 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HIST3H3... {November 7, 2007 2:23:15 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HIST3H3 image.jpg {November 7, 2007 2:23:45 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:24:01 AM PST}
- CREATED: Created new protein page: HIST3H3 {November 7, 2007 2:24:08 AM PST}
- INFO: Beginning work on HP... {November 7, 2007 2:11:49 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:12:44 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Haptoglobin
| HGNCid = 5141
| Symbol = HP
| AltSymbols =; MGC111141; hp2-alpha
| OMIM = 140100
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_HP_206697_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HP_208470_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0030492 |text = hemoglobin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0006952 |text = defense response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3240
| Hs_Ensembl = ENSG00000197711
| Hs_RefseqProtein = NP_005134
| Hs_RefseqmRNA = NM_005143
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 70646009
| Hs_GenLoc_end = 70652441
| Hs_Uniprot = P00738
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Haptoglobin''', also known as '''HP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Graversen JH, Madsen M, Moestrup SK |title=CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 4 |pages= 309-14 |year= 2002 |pmid= 11854028 |doi= }}
*{{cite journal | author=Madsen M, Graversen JH, Moestrup SK |title=Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes. |journal=Redox Rep. |volume=6 |issue= 6 |pages= 386-8 |year= 2002 |pmid= 11865982 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IGFBP5... {November 7, 2007 2:12:44 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IGFBP5 image.jpg {November 7, 2007 2:14:46 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:14:56 AM PST}
- CREATED: Created new protein page: IGFBP5 {November 7, 2007 2:15:03 AM PST}
- INFO: Beginning work on JUP... {November 7, 2007 2:15:03 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:15:43 AM PST}
- CREATED: Created new protein page: JUP {November 7, 2007 2:15:50 AM PST}
- INFO: Beginning work on MUC2... {November 7, 2007 2:15:50 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:16:10 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mucin 2, oligomeric mucus/gel-forming
| HGNCid = 7512
| Symbol = MUC2
| AltSymbols =; MLP; SMUC
| OMIM = 158370
| ECnumber =
| Homologene = 80094
| MGIid =
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030197 |text = extracellular matrix constituent, lubricant activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030277 |text = maintenance of gastrointestinal epithelium}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4583
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002448
| Hs_RefseqmRNA = NM_002457
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Mucin 2, oligomeric mucus/gel-forming''', also known as '''MUC2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.<ref>{{cite web | title = Entrez Gene: MUC2 mucin 2, oligomeric mucus/gel-forming| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4583| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Allen A, Hutton DA, Pearson JP |title=The MUC2 gene product: a human intestinal mucin. |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 7 |pages= 797-801 |year= 1998 |pmid= 9722984 |doi= }}
*{{cite journal | author=Byrd JC, Bresalier RS |title=Mucins and mucin binding proteins in colorectal cancer. |journal=Cancer Metastasis Rev. |volume=23 |issue= 1-2 |pages= 77-99 |year= 2004 |pmid= 15000151 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCOA2... {November 7, 2007 2:25:00 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:25:37 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear receptor coactivator 2
| HGNCid = 7669
| Symbol = NCOA2
| AltSymbols =; GRIP1; MGC138808; NCoA-2; TIF2
| OMIM = 601993
| ECnumber =
| Homologene = 4768
| MGIid = 1276533
| GeneAtlas_image1 = PBB_GE_NCOA2_gnf1h04995_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0030375 |text = thyroid hormone receptor coactivator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10499
| Hs_Ensembl = ENSG00000140396
| Hs_RefseqProtein = NP_006531
| Hs_RefseqmRNA = NM_006540
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 71196006
| Hs_GenLoc_end = 71478574
| Hs_Uniprot = Q15596
| Mm_EntrezGene = 17978
| Mm_Ensembl = ENSMUSG00000005886
| Mm_RefseqmRNA = NM_001077695
| Mm_RefseqProtein = NP_001071163
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 13127689
| Mm_GenLoc_end = 13359278
| Mm_Uniprot = Q61026
}}
}}
'''Nuclear receptor coactivator 2''', also known as '''NCOA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PF4... {November 7, 2007 2:16:10 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:16:45 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:16:59 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PF4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1f9q.
| PDB = {{PDB2|1f9q}}, {{PDB2|1f9r}}, {{PDB2|1f9s}}, {{PDB2|1pfm}}, {{PDB2|1pfn}}, {{PDB2|1rhp}}
| Name = Platelet factor 4 (chemokine (C-X-C motif) ligand 4)
| HGNCid = 8861
| Symbol = PF4
| AltSymbols =; CXCL4; MGC138298; SCYB4
| OMIM = 173460
| ECnumber =
| Homologene = 87791
| MGIid = 1888711
| GeneAtlas_image1 = PBB_GE_PF4_206390_x_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0030595 |text = leukocyte chemotaxis}} {{GNF_GO|id=GO:0045653 |text = negative regulation of megakaryocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5196
| Hs_Ensembl = ENSG00000163737
| Hs_RefseqProtein = NP_002610
| Hs_RefseqmRNA = NM_002619
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 75065660
| Hs_GenLoc_end = 75066541
| Hs_Uniprot = P02776
| Mm_EntrezGene = 56744
| Mm_Ensembl = ENSMUSG00000029373
| Mm_RefseqmRNA = NM_019932
| Mm_RefseqProtein = NP_064316
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 91847703
| Mm_GenLoc_end = 91848577
| Mm_Uniprot = Q3TVN6
}}
}}
'''Platelet factor 4 (chemokine (C-X-C motif) ligand 4)''', also known as '''PF4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PF4 platelet factor 4 (chemokine (C-X-C motif) ligand 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5196| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bikfalvi A, Gimenez-Gallego G |title=The control of angiogenesis and tumor invasion by platelet factor-4 and platelet factor-4-derived molecules. |journal=Semin. Thromb. Hemost. |volume=30 |issue= 1 |pages= 137-44 |year= 2004 |pmid= 15034805 |doi= 10.1055/s-2004-822978 }}
*{{cite journal | author=Maurer AM, Zhou B, Han ZC |title=Roles of platelet factor 4 in hematopoiesis and angiogenesis. |journal=Growth Factors |volume=24 |issue= 4 |pages= 242-52 |year= 2007 |pmid= 17381065 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on POLR2K... {November 7, 2007 2:16:59 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:18:00 AM PST}
- CREATED: Created new protein page: POLR2K {November 7, 2007 2:18:08 AM PST}
- INFO: Beginning work on REL... {November 7, 2007 2:18:08 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:18:44 AM PST}
- CREATED: Created new protein page: REL {November 7, 2007 2:18:51 AM PST}
- INFO: Beginning work on SOS1... {November 7, 2007 2:18:51 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SOS1 image.jpg {November 7, 2007 2:19:41 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:20:03 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SOS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1awe.
| PDB = {{PDB2|1awe}}, {{PDB2|1bkd}}, {{PDB2|1dbh}}, {{PDB2|1nvu}}, {{PDB2|1nvv}}, {{PDB2|1nvw}}, {{PDB2|1nvx}}, {{PDB2|1pms}}, {{PDB2|1q9c}}, {{PDB2|1xd2}}, {{PDB2|1xd4}}, {{PDB2|1xdv}}, {{PDB2|2ii0}}
| Name = Son of sevenless homolog 1 (Drosophila)
| HGNCid = 11187
| Symbol = SOS1
| AltSymbols =; GF1; HGF; GGF1; GINGF; NS4
| OMIM = 182530
| ECnumber =
| Homologene = 4117
| MGIid = 98354
| GeneAtlas_image1 = PBB_GE_SOS1_212777_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOS1_212780_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005100 |text = Rho GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6654
| Hs_Ensembl = ENSG00000115904
| Hs_RefseqProtein = NP_005624
| Hs_RefseqmRNA = NM_005633
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 39066469
| Hs_GenLoc_end = 39201067
| Hs_Uniprot = Q07889
| Mm_EntrezGene = 20662
| Mm_Ensembl = ENSMUSG00000024241
| Mm_RefseqmRNA = NM_009231
| Mm_RefseqProtein = NP_033257
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 80306507
| Mm_GenLoc_end = 80388261
| Mm_Uniprot = Q2M4G6
}}
}}
'''Son of sevenless homolog 1 (Drosophila)''', also known as '''SOS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SOS1 son of sevenless homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6654| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SPAST... {November 7, 2007 2:20:03 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:20:57 AM PST}
- CREATED: Created new protein page: SPAST {November 7, 2007 2:21:04 AM PST}
- INFO: Beginning work on TUBA4A... {November 7, 2007 2:21:54 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TUBA4A image.jpg {November 7, 2007 2:22:28 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:22:43 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TUBA4A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ffx.
| PDB = {{PDB2|1ffx}}, {{PDB2|1ia0}}, {{PDB2|1jff}}, {{PDB2|1sa0}}, {{PDB2|1sa1}}, {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}, {{PDB2|2hxf}}, {{PDB2|2hxh}}
| Name = Tubulin, alpha 4a
| HGNCid = 12407
| Symbol = TUBA4A
| AltSymbols =; FLJ30169; H2-ALPHA; TUBA1
| OMIM = 191110
| ECnumber =
| Homologene = 68496
| MGIid = 1095410
| GeneAtlas_image1 = PBB_GE_TUBA4A_212242_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7277
| Hs_Ensembl = ENSG00000127824
| Hs_RefseqProtein = NP_005991
| Hs_RefseqmRNA = NM_006000
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 219822677
| Hs_GenLoc_end = 219826882
| Hs_Uniprot = P68366
| Mm_EntrezGene = 22145
| Mm_Ensembl = ENSMUSG00000026202
| Mm_RefseqmRNA = NM_009447
| Mm_RefseqProtein = NP_033473
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 75098770
| Mm_GenLoc_end = 75100582
| Mm_Uniprot = Q3TY31
}}
}}
'''Tubulin, alpha 4a''', also known as '''TUBA4A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.<ref>{{cite web | title = Entrez Gene: TUBA4A tubulin, alpha 4a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7277| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Desai A, Mitchison TJ |title=Tubulin and FtsZ structures: functional and therapeutic implications. |journal=Bioessays |volume=20 |issue= 7 |pages= 523-7 |year= 1998 |pmid= 9722999 |doi= 10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L }}
*{{cite journal | author=Oakley BR |title=An abundance of tubulins. |journal=Trends Cell Biol. |volume=10 |issue= 12 |pages= 537-42 |year= 2001 |pmid= 11121746 |doi= }}
*{{cite journal | author=Dutcher SK |title=The tubulin fraternity: alpha to eta. |journal=Curr. Opin. Cell Biol. |volume=13 |issue= 1 |pages= 49-54 |year= 2001 |pmid= 11163133 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on YWHAH... {November 7, 2007 2:22:43 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein YWHAH image.jpg {November 7, 2007 2:22:57 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:23:07 AM PST}
- CREATED: Created new protein page: YWHAH {November 7, 2007 2:23:14 AM PST}
- INFO: Beginning work on YWHAQ... {November 7, 2007 2:25:37 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein YWHAQ image.jpg {November 7, 2007 2:26:44 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:27:01 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_YWHAQ_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2btp.
| PDB = {{PDB2|2btp}}
| Name = Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
| HGNCid = 12854
| Symbol = YWHAQ
| AltSymbols =; HS1; 14-3-3; 1C5
| OMIM = 609009
| ECnumber =
| Homologene = 48407
| MGIid = 891963
| GeneAtlas_image1 = PBB_GE_YWHAQ_212426_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YWHAQ_200693_at_tn.png
| GeneAtlas_image3 = PBB_GE_YWHAQ_213699_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008426 |text = protein kinase C inhibitor activity}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10971
| Hs_Ensembl = ENSG00000134308
| Hs_RefseqProtein = NP_006817
| Hs_RefseqmRNA = NM_006826
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 9641552
| Hs_GenLoc_end = 9688629
| Hs_Uniprot = P27348
| Mm_EntrezGene = 22630
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011739
| Mm_RefseqProtein = NP_035869
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide''', also known as '''YWHAQ''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.<ref>{{cite web | title = Entrez Gene: YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10971| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
*{{cite journal | author=Calinisan V, Gravem D, Chen RP, ''et al.'' |title=New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. |journal=Front. Biosci. |volume=11 |issue= |pages= 1646-66 |year= 2006 |pmid= 16368544 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
