Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 01:01, 7 November 2007 (UTC)[edit]
Proteins without matches (15)[edit]
Proteins with a High Potential Match (9)[edit]
Created (2)[edit]
Manual Inspection (Page not found) (22)[edit]
Protein Status Grid - Date: 01:01, 7 November 2007 (UTC)[edit]
Vebose Log - Date: 01:01, 7 November 2007 (UTC)[edit]
- INFO: Beginning work on ACTG1... {November 6, 2007 4:26:13 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 4:29:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:30:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACTG1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1atn.
| PDB = {{PDB2|1atn}}, {{PDB2|1c0f}}, {{PDB2|1c0g}}, {{PDB2|1d4x}}, {{PDB2|1dej}}, {{PDB2|1eqy}}, {{PDB2|1esv}}, {{PDB2|1h1v}}, {{PDB2|1hlu}}, {{PDB2|1ijj}}, {{PDB2|1j6z}}, {{PDB2|1kxp}}, {{PDB2|1lcu}}, {{PDB2|1lot}}, {{PDB2|1m8q}}, {{PDB2|1ma9}}, {{PDB2|1mdu}}, {{PDB2|1mvw}}, {{PDB2|1nlv}}, {{PDB2|1nm1}}, {{PDB2|1nmd}}, {{PDB2|1nwk}}, {{PDB2|1o18}}, {{PDB2|1o19}}, {{PDB2|1o1a}}, {{PDB2|1o1b}}, {{PDB2|1o1c}}, {{PDB2|1o1d}}, {{PDB2|1o1e}}, {{PDB2|1o1f}}, {{PDB2|1o1g}}, {{PDB2|1p8z}}, {{PDB2|1qz5}}, {{PDB2|1qz6}}, {{PDB2|1rdw}}, {{PDB2|1rfq}}, {{PDB2|1rgi}}, {{PDB2|1s22}}, {{PDB2|1sqk}}, {{PDB2|1t44}}, {{PDB2|1wua}}, {{PDB2|1y64}}, {{PDB2|1yxq}}, {{PDB2|2a3z}}, {{PDB2|2a40}}, {{PDB2|2a41}}, {{PDB2|2a42}}, {{PDB2|2a5x}}, {{PDB2|2asm}}, {{PDB2|2aso}}, {{PDB2|2asp}}, {{PDB2|2btf}}, {{PDB2|2d1k}}, {{PDB2|2ff3}}, {{PDB2|2ff6}}, {{PDB2|2fxu}}, {{PDB2|2gwj}}, {{PDB2|2gwk}}, {{PDB2|2hf3}}, {{PDB2|2hf4}}, {{PDB2|2hmp}}, {{PDB2|2oan}}, {{PDB2|2q1n}}, {{PDB2|2q31}}, {{PDB2|2q36}}
| Name = Actin, gamma 1
| HGNCid = 144
| Symbol = ACTG1
| AltSymbols =; ACT; ACTG; DFNA20; DFNA26
| OMIM = 102560
| ECnumber =
| Homologene = 74402
| MGIid = 87906
| GeneAtlas_image1 = PBB_GE_ACTG1_211983_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_ACTG1_201550_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ACTG1_211970_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030016 |text = myofibril}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0045214 |text = sarcomere organization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 71
| Hs_Ensembl = ENSG00000184009
| Hs_RefseqProtein = NP_001605
| Hs_RefseqmRNA = NM_001614
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 77091594
| Hs_GenLoc_end = 77094422
| Hs_Uniprot = P63261
| Mm_EntrezGene = 11465
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001052054
| Mm_RefseqProtein = XP_001052054
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Actin, gamma 1''', also known as '''ACTG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells.<ref>{{cite web | title = Entrez Gene: ACTG1 actin, gamma 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=71| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227-30 |year= 1997 |pmid= 8997639 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADRBK1... {November 6, 2007 4:30:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ADRBK1 image.jpg {November 6, 2007 4:31:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:31:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ADRBK1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bak.
| PDB = {{PDB2|1bak}}, {{PDB2|1omw}}, {{PDB2|1ym7}}, {{PDB2|2bcj}}
| Name = Adrenergic, beta, receptor kinase 1
| HGNCid = 289
| Symbol = ADRBK1
| AltSymbols =; BARK1; BETA-ARK1; GRK2
| OMIM = 109635
| ECnumber =
| Homologene = 1223
| MGIid = 87940
| GeneAtlas_image1 = PBB_GE_ADRBK1_38447_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADRBK1_201401_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ADRBK1_201402_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004703 |text = G-protein coupled receptor kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0002026 |text = cardiac inotropy}} {{GNF_GO|id=GO:0002029 |text = desensitization of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 156
| Hs_Ensembl = ENSG00000173020
| Hs_RefseqProtein = NP_001610
| Hs_RefseqmRNA = NM_001619
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 66790507
| Hs_GenLoc_end = 66810602
| Hs_Uniprot = P25098
| Mm_EntrezGene = 110355
| Mm_Ensembl = ENSMUSG00000024858
| Mm_RefseqmRNA = NM_130863
| Mm_RefseqProtein = NP_570933
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 4286001
| Mm_GenLoc_end = 4306014
| Mm_Uniprot = Q3U5J8
}}
}}
'''Adrenergic, beta, receptor kinase 1''', also known as '''ADRBK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.<ref>{{cite web | title = Entrez Gene: ADRBK1 adrenergic, beta, receptor kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=156| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ANGPT1... {November 6, 2007 4:31:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:32:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Angiopoietin 1
| HGNCid = 484
| Symbol = ANGPT1
| AltSymbols =; AGP1; AGPT; ANG1
| OMIM = 601667
| ECnumber =
| Homologene = 37447
| MGIid = 108448
| GeneAtlas_image1 = PBB_GE_ANGPT1_205608_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ANGPT1_205609_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component =
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 284
| Hs_Ensembl = ENSG00000154188
| Hs_RefseqProtein = NP_001137
| Hs_RefseqmRNA = NM_001146
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 108330899
| Hs_GenLoc_end = 108579459
| Hs_Uniprot = Q15389
| Mm_EntrezGene = 11600
| Mm_Ensembl = ENSMUSG00000022309
| Mm_RefseqmRNA = NM_009640
| Mm_RefseqProtein = NP_033770
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 42254801
| Mm_GenLoc_end = 42507051
| Mm_Uniprot = Q6A0F0
}}
}}
'''Angiopoietin 1''', also known as '''ANGPT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.<ref>{{cite web | title = Entrez Gene: ANGPT1 angiopoietin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
*{{cite journal | author=Metheny-Barlow LJ, Li LY |title=The enigmatic role of angiopoietin-1 in tumor angiogenesis. |journal=Cell Res. |volume=13 |issue= 5 |pages= 309-17 |year= 2004 |pmid= 14672554 |doi= 10.1038/sj.cr.7290176 }}
*{{cite journal | author=Makinde T, Murphy RF, Agrawal DK |title=Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling. |journal=Curr. Mol. Med. |volume=6 |issue= 8 |pages= 831-41 |year= 2007 |pmid= 17168735 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BCAR1... {November 6, 2007 4:55:39 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BCAR1 image.jpg {November 6, 2007 4:56:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:56:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BCAR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wyx.
| PDB = {{PDB2|1wyx}}
| Name = Breast cancer anti-estrogen resistance 1
| HGNCid = 971
| Symbol = BCAR1
| AltSymbols =; CAS; CRKAS; P130Cas
| OMIM = 602941
| ECnumber =
| Homologene = 7674
| MGIid = 108091
| GeneAtlas_image1 = PBB_GE_BCAR1_gnf1h00170_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0019903 |text = protein phosphatase binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0007015 |text = actin filament organization}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008286 |text = insulin receptor signaling pathway}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030335 |text = positive regulation of cell migration}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0048008 |text = platelet-derived growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0048011 |text = nerve growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}} {{GNF_GO|id=GO:0050853 |text = B cell receptor signaling pathway}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9564
| Hs_Ensembl = ENSG00000050820
| Hs_RefseqProtein = NP_055382
| Hs_RefseqmRNA = NM_014567
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 73820430
| Hs_GenLoc_end = 73843004
| Hs_Uniprot = P56945
| Mm_EntrezGene = 12927
| Mm_Ensembl = ENSMUSG00000031955
| Mm_RefseqmRNA = NM_009954
| Mm_RefseqProtein = NP_034084
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 114597147
| Mm_GenLoc_end = 114608054
| Mm_Uniprot = Q3TIT7
}}
}}
'''Breast cancer anti-estrogen resistance 1''', also known as '''BCAR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rozengurt E |title=Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists. |journal=J. Cell. Physiol. |volume=177 |issue= 4 |pages= 507-17 |year= 1999 |pmid= 10092204 |doi= 10.1002/(SICI)1097-4652(199812)177:4<507::AID-JCP2>3.0.CO;2-K }}
*{{cite journal | author=O'Neill GM, Fashena SJ, Golemis EA |title=Integrin signalling: a new Cas(t) of characters enters the stage. |journal=Trends Cell Biol. |volume=10 |issue= 3 |pages= 111-9 |year= 2000 |pmid= 10675905 |doi= }}
*{{cite journal | author=Bouton AH, Riggins RB, Bruce-Staskal PJ |title=Functions of the adapter protein Cas: signal convergence and the determination of cellular responses. |journal=Oncogene |volume=20 |issue= 44 |pages= 6448-58 |year= 2001 |pmid= 11607844 |doi= 10.1038/sj.onc.1204785 }}
*{{cite journal | author=Panetti TS |title=Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. |journal=Front. Biosci. |volume=7 |issue= |pages= d143-50 |year= 2002 |pmid= 11779709 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BCL2L11... {November 6, 2007 4:56:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:58:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BCL2-like 11 (apoptosis facilitator)
| HGNCid = 994
| Symbol = BCL2L11
| AltSymbols =; BAM; BIM; BIM-alpha6; BIM-beta6; BIM-beta7; BOD; BimEL; BimL
| OMIM = 603827
| ECnumber =
| Homologene = 7643
| MGIid = 1197519
| GeneAtlas_image1 = PBB_GE_BCL2L11_208536_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BCL2L11_222343_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10018
| Hs_Ensembl = ENSG00000153094
| Hs_RefseqProtein = NP_619528
| Hs_RefseqmRNA = NM_138622
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 111597781
| Hs_GenLoc_end = 111641054
| Hs_Uniprot = O43521
| Mm_EntrezGene = 12125
| Mm_Ensembl = ENSMUSG00000027381
| Mm_RefseqmRNA = NM_009754
| Mm_RefseqProtein = NP_033884
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 127817479
| Mm_GenLoc_end = 127853613
| Mm_Uniprot = Q542N5
}}
}}
'''BCL2-like 11 (apoptosis facilitator)''', also known as '''BCL2L11''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.<ref>{{cite web | title = Entrez Gene: BCL2L11 BCL2-like 11 (apoptosis facilitator)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10018| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSF1... {November 6, 2007 4:32:47 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 4:33:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:34:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hmc.
| PDB = {{PDB2|1hmc}}
| Name = Colony stimulating factor 1 (macrophage)
| HGNCid = 2432
| Symbol = CSF1
| AltSymbols =; MCSF; MGC31930
| OMIM = 120420
| ECnumber =
| Homologene = 7282
| MGIid = 1339753
| GeneAtlas_image1 = PBB_GE_CSF1_211839_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CSF1_207082_at_tn.png
| Function = {{GNF_GO|id=GO:0005157 |text = macrophage colony stimulating factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030225 |text = macrophage differentiation}} {{GNF_GO|id=GO:0030278 |text = regulation of ossification}} {{GNF_GO|id=GO:0040018 |text = positive regulation of body size}} {{GNF_GO|id=GO:0042488 |text = positive regulation of odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045672 |text = positive regulation of osteoclast differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1435
| Hs_Ensembl = ENSG00000184371
| Hs_RefseqProtein = NP_000748
| Hs_RefseqmRNA = NM_000757
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 110254778
| Hs_GenLoc_end = 110275144
| Hs_Uniprot = P09603
| Mm_EntrezGene = 12977
| Mm_Ensembl = ENSMUSG00000014599
| Mm_RefseqmRNA = NM_007778
| Mm_RefseqProtein = NP_031804
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 107869116
| Mm_GenLoc_end = 107888525
| Mm_Uniprot = Q3TDK0
}}
}}
'''Colony stimulating factor 1 (macrophage)''', also known as '''CSF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Four transcript variants encoding three different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CSF1 colony stimulating factor 1 (macrophage)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1435| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stanley ER, Berg KL, Einstein DB, ''et al.'' |title=The biology and action of colony stimulating factor-1. |journal=Stem Cells |volume=12 Suppl 1 |issue= |pages= 15-24; discussion 25 |year= 1995 |pmid= 7696959 |doi= }}
*{{cite journal | author=Alterman RL, Stanley ER |title=Colony stimulating factor-1 expression in human glioma. |journal=Mol. Chem. Neuropathol. |volume=21 |issue= 2-3 |pages= 177-88 |year= 1994 |pmid= 8086034 |doi= }}
*{{cite journal | author=Stanley ER, Berg KL, Einstein DB, ''et al.'' |title=Biology and action of colony--stimulating factor-1. |journal=Mol. Reprod. Dev. |volume=46 |issue= 1 |pages= 4-10 |year= 1997 |pmid= 8981357 |doi= 10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V }}
*{{cite journal | author=Sweet MJ, Hume DA |title=CSF-1 as a regulator of macrophage activation and immune responses. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=51 |issue= 3 |pages= 169-77 |year= 2004 |pmid= 12894871 |doi= }}
*{{cite journal | author=Mroczko B, Szmitkowski M |title=Hematopoietic cytokines as tumor markers. |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 12 |pages= 1347-54 |year= 2005 |pmid= 15576295 |doi= 10.1515/CCLM.2004.253 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DNMT1... {November 6, 2007 4:34:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:35:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = DNA (cytosine-5-)-methyltransferase 1
| HGNCid = 2976
| Symbol = DNMT1
| AltSymbols =; CXXC9; DNMT; FLJ16293; MCMT; MGC104992
| OMIM = 126375
| ECnumber =
| Homologene = 1055
| MGIid = 94912
| GeneAtlas_image1 = PBB_GE_DNMT1_201697_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003886 |text = DNA (cytosine-5-)-methyltransferase activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006306 |text = DNA methylation}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1786
| Hs_Ensembl = ENSG00000130816
| Hs_RefseqProtein = NP_001370
| Hs_RefseqmRNA = NM_001379
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 10105023
| Hs_GenLoc_end = 10166811
| Hs_Uniprot = P26358
| Mm_EntrezGene = 13433
| Mm_Ensembl = ENSMUSG00000004099
| Mm_RefseqmRNA = NM_010066
| Mm_RefseqProtein = NP_034196
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 20657611
| Mm_GenLoc_end = 20703267
| Mm_Uniprot = Q0VDW2
}}
}}
'''DNA (cytosine-5-)-methyltransferase 1''', also known as '''DNMT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.<ref>{{cite web | title = Entrez Gene: DNMT1 DNA (cytosine-5-)-methyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1786| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FGB... {November 6, 2007 4:35:02 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FGB image.jpg {November 6, 2007 4:36:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:36:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FGB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fza.
| PDB = {{PDB2|1fza}}, {{PDB2|1fzb}}, {{PDB2|1fzc}}, {{PDB2|1fze}}, {{PDB2|1fzf}}, {{PDB2|1fzg}}, {{PDB2|1lt9}}, {{PDB2|1ltj}}, {{PDB2|1n86}}, {{PDB2|1n8e}}, {{PDB2|1re3}}, {{PDB2|1re4}}, {{PDB2|1rf0}}, {{PDB2|1rf1}}, {{PDB2|2a45}}, {{PDB2|2ffd}}, {{PDB2|2h43}}, {{PDB2|2hod}}, {{PDB2|2hpc}}, {{PDB2|2oyh}}, {{PDB2|2oyi}}
| Name = Fibrinogen beta chain
| HGNCid = 3662
| Symbol = FGB
| AltSymbols =; MGC104327; MGC120405
| OMIM = 134830
| ECnumber =
| Homologene = 3772
| MGIid = 99501
| GeneAtlas_image1 = PBB_GE_FGB_216238_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FGB_204988_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005577 |text = fibrinogen complex}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2244
| Hs_Ensembl = ENSG00000171564
| Hs_RefseqProtein = NP_005132
| Hs_RefseqmRNA = NM_005141
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 155703596
| Hs_GenLoc_end = 155711683
| Hs_Uniprot = P02675
| Mm_EntrezGene = 110135
| Mm_Ensembl = ENSMUSG00000033831
| Mm_RefseqmRNA = NM_181849
| Mm_RefseqProtein = NP_862897
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 83128174
| Mm_GenLoc_end = 83135736
| Mm_Uniprot = Q3TGR2
}}
}}
'''Fibrinogen beta chain''', also known as '''FGB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.<ref>{{cite web | title = Entrez Gene: FGB fibrinogen beta chain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2244| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Doolittle RF |title=Fibrinogen and fibrin. |journal=Annu. Rev. Biochem. |volume=53 |issue= |pages= 195-229 |year= 1984 |pmid= 6383194 |doi= 10.1146/annurev.bi.53.070184.001211 }}
*{{cite journal | author=Vasse M, Paysant J, Soria J, ''et al.'' |title=Regulation of fibrinogen biosynthesis by cytokines, consequences on the vascular risk. |journal=Haemostasis |volume=26 Suppl 4 |issue= |pages= 331-9 |year= 1997 |pmid= 8979138 |doi= }}
*{{cite journal | author=Herrick S, Blanc-Brude O, Gray A, Laurent G |title=Fibrinogen. |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 7 |pages= 741-6 |year= 1999 |pmid= 10467729 |doi= }}
*{{cite journal | author=Redman CM, Xia H |title=Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 480-95 |year= 2001 |pmid= 11460506 |doi= }}
*{{cite journal | author=Brennan SO, Fellowes AP, George PM |title=Molecular mechanisms of hypo- and afibrinogenemia. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 91-100 |year= 2001 |pmid= 11460528 |doi= }}
*{{cite journal | author=Everse SJ |title=New insights into fibrin (ogen) structure and function. |journal=Vox Sang. |volume=83 Suppl 1 |issue= |pages= 375-82 |year= 2003 |pmid= 12617173 |doi= }}
*{{cite journal | author=Scott EM, Ariëns RA, Grant PJ |title=Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 9 |pages= 1558-66 |year= 2005 |pmid= 15217804 |doi= 10.1161/01.ATV.0000136649.83297.bf }}
*{{cite journal | author=Lord ST |title=Fibrinogen and fibrin: scaffold proteins in hemostasis. |journal=Curr. Opin. Hematol. |volume=14 |issue= 3 |pages= 236-41 |year= 2007 |pmid= 17414213 |doi= 10.1097/MOH.0b013e3280dce58c }}
*{{cite journal | author=Chen XC, Xu MT, Zhou W, ''et al.'' |title=A meta-analysis of relationship between beta-fibrinogen gene -148C/T polymorphism and susceptibility to cerebral infarction in Han Chinese. |journal=Chin. Med. J. |volume=120 |issue= 13 |pages= 1198-202 |year= 2007 |pmid= 17637253 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FGF1... {November 6, 2007 4:36:20 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FGF1 image.jpg {November 6, 2007 4:37:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:38:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FGF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1afc.
| PDB = {{PDB2|1afc}}, {{PDB2|1axm}}, {{PDB2|1bar}}, {{PDB2|1djs}}, {{PDB2|1dzc}}, {{PDB2|1dzd}}, {{PDB2|1e0o}}, {{PDB2|1evt}}, {{PDB2|1hkn}}, {{PDB2|1jqz}}, {{PDB2|1jt3}}, {{PDB2|1jt4}}, {{PDB2|1jt5}}, {{PDB2|1jt7}}, {{PDB2|1jtc}}, {{PDB2|1jy0}}, {{PDB2|1k5u}}, {{PDB2|1k5v}}, {{PDB2|1m16}}, {{PDB2|1nzk}}, {{PDB2|1p63}}, {{PDB2|1pzz}}, {{PDB2|1q03}}, {{PDB2|1q04}}, {{PDB2|1rg8}}, {{PDB2|1rml}}, {{PDB2|1ry7}}, {{PDB2|1yto}}, {{PDB2|1z2v}}, {{PDB2|1z4s}}, {{PDB2|2afg}}, {{PDB2|2aqz}}, {{PDB2|2axm}}, {{PDB2|2erm}}, {{PDB2|2j3p}}
| Name = Fibroblast growth factor 1 (acidic)
| HGNCid = 3665
| Symbol = FGF1
| AltSymbols =; AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-alpha; FGFA; GLIO703; HBGF1
| OMIM = 131220
| ECnumber =
| Homologene = 625
| MGIid = 95515
| GeneAtlas_image1 = PBB_GE_FGF1_205117_at_tn.png
| GeneAtlas_image2 = PBB_GE_FGF1_208240_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001759 |text = induction of an organ}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030324 |text = lung development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2246
| Hs_Ensembl = ENSG00000113578
| Hs_RefseqProtein = NP_000791
| Hs_RefseqmRNA = NM_000800
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 141951927
| Hs_GenLoc_end = 142046134
| Hs_Uniprot = P05230
| Mm_EntrezGene = 14164
| Mm_Ensembl = ENSMUSG00000036585
| Mm_RefseqmRNA = NM_010197
| Mm_RefseqProtein = NP_034327
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 38965154
| Mm_GenLoc_end = 39044673
| Mm_Uniprot = Q6ZWS1
}}
}}
'''Fibroblast growth factor 1 (acidic)''', also known as '''FGF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.<ref>{{cite web | title = Entrez Gene: FGF1 fibroblast growth factor 1 (acidic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2246| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRIN2B... {November 6, 2007 4:38:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:39:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, ionotropic, N-methyl D-aspartate 2B
| HGNCid = 4586
| Symbol = GRIN2B
| AltSymbols =; MGC142178; MGC142180; NMDAR2B; NR2B; hNR3
| OMIM = 138252
| ECnumber =
| Homologene = 646
| MGIid = 95821
| GeneAtlas_image1 = PBB_GE_GRIN2B_210412_at_tn.png
| GeneAtlas_image2 = PBB_GE_GRIN2B_210411_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004972 |text = N-methyl-D-aspartate selective glutamate receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005234 |text = extracellular-glutamate-gated ion channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0042734 |text = presynaptic membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007215 |text = glutamate signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2904
| Hs_Ensembl = ENSG00000150086
| Hs_RefseqProtein = NP_000825
| Hs_RefseqmRNA = NM_000834
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 13605411
| Hs_GenLoc_end = 14024319
| Hs_Uniprot = Q13224
| Mm_EntrezGene = 14812
| Mm_Ensembl = ENSMUSG00000030209
| Mm_RefseqmRNA = NM_008171
| Mm_RefseqProtein = NP_032197
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 135697791
| Mm_GenLoc_end = 136009994
| Mm_Uniprot = Q8CG69
}}
}}
'''Glutamate receptor, ionotropic, N-methyl D-aspartate 2B''', also known as '''GRIN2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA)<ref>{{cite web | title = Entrez Gene: GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2904| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nagy J |title=The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence. |journal=Current drug targets. CNS and neurological disorders |volume=3 |issue= 3 |pages= 169-79 |year= 2004 |pmid= 15180478 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GSN... {November 6, 2007 4:39:21 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GSN image.jpg {November 6, 2007 4:40:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:40:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GSN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c0f.
| PDB = {{PDB2|1c0f}}, {{PDB2|1c0g}}, {{PDB2|1d0n}}, {{PDB2|1d4x}}, {{PDB2|1dej}}, {{PDB2|1eqy}}, {{PDB2|1esv}}, {{PDB2|1h1v}}, {{PDB2|1kcq}}, {{PDB2|1mdu}}, {{PDB2|1nlv}}, {{PDB2|1nm1}}, {{PDB2|1nmd}}, {{PDB2|1nph}}, {{PDB2|1p8x}}, {{PDB2|1p8z}}, {{PDB2|1rgi}}, {{PDB2|1t44}}, {{PDB2|1yag}}, {{PDB2|1yvn}}, {{PDB2|2ff3}}, {{PDB2|2ff6}}, {{PDB2|2fgh}}, {{PDB2|2fh1}}, {{PDB2|2fh2}}, {{PDB2|2fh3}}, {{PDB2|2fh4}}
| Name = Gelsolin (amyloidosis, Finnish type)
| HGNCid = 4620
| Symbol = GSN
| AltSymbols =; DKFZp313L0718
| OMIM = 137350
| ECnumber =
| Homologene = 147
| MGIid = 95851
| GeneAtlas_image1 = PBB_GE_GSN_200696_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GSN_214040_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}}
| Process = {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}} {{GNF_GO|id=GO:0030041 |text = actin filament polymerization}} {{GNF_GO|id=GO:0051014 |text = actin filament severing}} {{GNF_GO|id=GO:0051016 |text = barbed-end actin filament capping}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2934
| Hs_Ensembl = ENSG00000148180
| Hs_RefseqProtein = NP_000168
| Hs_RefseqmRNA = NM_000177
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 123070228
| Hs_GenLoc_end = 123134941
| Hs_Uniprot = P06396
| Mm_EntrezGene = 227753
| Mm_Ensembl = ENSMUSG00000026879
| Mm_RefseqmRNA = NM_146120
| Mm_RefseqProtein = NP_666232
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 35104449
| Mm_GenLoc_end = 35129901
| Mm_Uniprot = Q3TGJ9
}}
}}
'''Gelsolin (amyloidosis, Finnish type)''', also known as '''GSN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fujita H |title=[An actin-regulatory protein, gelsolin functions as a regulator of cell growth and apoptosis] |journal=Seikagaku |volume=74 |issue= 2 |pages= 135-9 |year= 2002 |pmid= 11925941 |doi= }}
*{{cite journal | author=Silacci P, Mazzolai L, Gauci C, ''et al.'' |title=Gelsolin superfamily proteins: key regulators of cellular functions. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 19-20 |pages= 2614-23 |year= 2004 |pmid= 15526166 |doi= 10.1007/s00018-004-4225-6 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HLA-DPB1... {November 6, 2007 4:40:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:41:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Major histocompatibility complex, class II, DP beta 1
| HGNCid = 4940
| Symbol = HLA-DPB1
| AltSymbols =; DPB1; HLA-DP1B; MHC DPB1
| OMIM = 142858
| ECnumber =
| Homologene = 88656
| MGIid =
| GeneAtlas_image1 = PBB_GE_HLA-DPB1_201137_s_at_tn.png
| Function = {{GNF_GO|id=GO:0032395 |text = MHC class II receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3115
| Hs_Ensembl = ENSG00000168383
| Hs_RefseqProtein = NP_002112
| Hs_RefseqmRNA = NM_002121
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 33151694
| Hs_GenLoc_end = 33162956
| Hs_Uniprot = P04232
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Major histocompatibility complex, class II, DP beta 1''', also known as '''HLA-DPB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.<ref>{{cite web | title = Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3115| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HPSE... {November 6, 2007 4:58:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:59:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heparanase
| HGNCid = 5164
| Symbol = HPSE
| AltSymbols =; HPR1; HPA; HPSE1; HSE1
| OMIM = 604724
| ECnumber =
| Homologene = 68528
| MGIid = 1343124
| GeneAtlas_image1 = PBB_GE_HPSE_219403_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004566 |text = beta-glucuronidase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006029 |text = proteoglycan metabolic process}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10855
| Hs_Ensembl = ENSG00000173083
| Hs_RefseqProtein = NP_006656
| Hs_RefseqmRNA = NM_006665
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 84432639
| Hs_GenLoc_end = 84475329
| Hs_Uniprot = Q9Y251
| Mm_EntrezGene = 15442
| Mm_Ensembl = ENSMUSG00000035273
| Mm_RefseqmRNA = XM_982223
| Mm_RefseqProtein = XP_987317
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 100920698
| Mm_GenLoc_end = 100959985
| Mm_Uniprot = Q6YGZ1
}}
}}
'''Heparanase''', also known as '''HPSE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Zcharia E, Metzger S, Chajek-Shaul T, ''et al.'' |title=Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis. |journal=Journal of mammary gland biology and neoplasia |volume=6 |issue= 3 |pages= 311-22 |year= 2002 |pmid= 11547900 |doi= }}
*{{cite journal | author=Vlodavsky I, Goldshmidt O, Zcharia E, ''et al.'' |title=Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development. |journal=Semin. Cancer Biol. |volume=12 |issue= 2 |pages= 121-9 |year= 2003 |pmid= 12027584 |doi= 10.1006/scbi.2001.0420 }}
*{{cite journal | author=Vlodavsky I, Abboud-Jarrous G, Elkin M, ''et al.'' |title=The impact of heparanese and heparin on cancer metastasis and angiogenesis. |journal=Pathophysiol. Haemost. Thromb. |volume=35 |issue= 1-2 |pages= 116-27 |year= 2006 |pmid= 16855356 |doi= 10.1159/000093553 }}
*{{cite journal | author=van den Hoven MJ, Rops AL, Vlodavsky I, ''et al.'' |title=Heparanase in glomerular diseases. |journal=Kidney Int. |volume=72 |issue= 5 |pages= 543-8 |year= 2007 |pmid= 17519955 |doi= 10.1038/sj.ki.5002337 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL8RB... {November 6, 2007 4:41:36 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 4:42:35 PM PST}
- CREATED: Created new protein page: IL8RB {November 6, 2007 4:42:46 PM PST}
- INFO: Beginning work on ILK... {November 6, 2007 4:42:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:43:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Integrin-linked kinase
| HGNCid = 6040
| Symbol = ILK
| AltSymbols =; DKFZp686F1765; P59
| OMIM = 602366
| ECnumber =
| Homologene = 3318
| MGIid = 1195267
| GeneAtlas_image1 = PBB_GE_ILK_201234_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}}
| Process = {{GNF_GO|id=GO:0001658 |text = ureteric bud branching}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0045197 |text = establishment and/or maintenance of epithelial cell polarity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3611
| Hs_Ensembl = ENSG00000166333
| Hs_RefseqProtein = NP_001014794
| Hs_RefseqmRNA = NM_001014794
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 6581540
| Hs_GenLoc_end = 6588673
| Hs_Uniprot = Q13418
| Mm_EntrezGene = 16202
| Mm_Ensembl = ENSMUSG00000030890
| Mm_RefseqmRNA = NM_010562
| Mm_RefseqProtein = NP_034692
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 105610473
| Mm_GenLoc_end = 105616745
| Mm_Uniprot = O55222
}}
}}
'''Integrin-linked kinase''', also known as '''ILK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: ILK integrin-linked kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3611| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dedhar S |title=Cell-substrate interactions and signaling through ILK. |journal=Curr. Opin. Cell Biol. |volume=12 |issue= 2 |pages= 250-6 |year= 2000 |pmid= 10712922 |doi= }}
*{{cite journal | author=Persad S, Dedhar S |title=The role of integrin-linked kinase (ILK) in cancer progression. |journal=Cancer Metastasis Rev. |volume=22 |issue= 4 |pages= 375-84 |year= 2004 |pmid= 12884912 |doi= }}
*{{cite journal | author=Srivastava D, Yu S |title=Stretching to meet needs: integrin-linked kinase and the cardiac pump. |journal=Genes Dev. |volume=20 |issue= 17 |pages= 2327-31 |year= 2006 |pmid= 16951248 |doi= 10.1101/gad.1472506 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KITLG... {November 6, 2007 4:44:50 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KITLG image.jpg {November 6, 2007 4:45:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:46:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_KITLG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1exz.
| PDB = {{PDB2|1exz}}, {{PDB2|1scf}}
| Name = KIT ligand
| HGNCid = 6343
| Symbol = KITLG
| AltSymbols =; SF; DKFZp686F2250; KL-1; Kitl; MGF; SCF
| OMIM = 184745
| ECnumber =
| Homologene = 692
| MGIid = 96974
| GeneAtlas_image1 = PBB_GE_KITLG_207029_at_tn.png
| GeneAtlas_image2 = PBB_GE_KITLG_211124_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005173 |text = stem cell factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4254
| Hs_Ensembl = ENSG00000049130
| Hs_RefseqProtein = NP_000890
| Hs_RefseqmRNA = NM_000899
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 87410697
| Hs_GenLoc_end = 87498369
| Hs_Uniprot = P21583
| Mm_EntrezGene = 17311
| Mm_Ensembl = ENSMUSG00000019966
| Mm_RefseqmRNA = NM_013598
| Mm_RefseqProtein = NP_038626
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 99445514
| Mm_GenLoc_end = 99518923
| Mm_Uniprot = Q61854
}}
}}
'''KIT ligand''', also known as '''KITLG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: KITLG KIT ligand| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4254| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Broudy VC |title=Stem cell factor and hematopoiesis. |journal=Blood |volume=90 |issue= 4 |pages= 1345-64 |year= 1997 |pmid= 9269751 |doi= }}
*{{cite journal | author=Andrews RG, Briddell RA, Appelbaum FR, McNiece IK |title=Stimulation of hematopoiesis in vivo by stem cell factor. |journal=Curr. Opin. Hematol. |volume=1 |issue= 3 |pages= 187-96 |year= 1999 |pmid= 9371281 |doi= }}
*{{cite journal | author=Wehrle-Haller B |title=The role of Kit-ligand in melanocyte development and epidermal homeostasis. |journal=Pigment Cell Res. |volume=16 |issue= 3 |pages= 287-96 |year= 2004 |pmid= 12753403 |doi= }}
*{{cite journal | author=Rönnstrand L |title=Signal transduction via the stem cell factor receptor/c-Kit. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 19-20 |pages= 2535-48 |year= 2004 |pmid= 15526160 |doi= 10.1007/s00018-004-4189-6 }}
*{{cite journal | author=Mroczko B, Szmitkowski M |title=Hematopoietic cytokines as tumor markers. |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 12 |pages= 1347-54 |year= 2005 |pmid= 15576295 |doi= 10.1515/CCLM.2004.253 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KRT8... {November 6, 2007 4:43:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:44:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 8
| HGNCid = 6446
| Symbol = KRT8
| AltSymbols =; K8; CARD2; CK8; CYK8; K2C8; KO
| OMIM = 148060
| ECnumber =
| Homologene = 55643
| MGIid = 96705
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
| Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3856
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002264
| Hs_RefseqmRNA = NM_002273
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16691
| Mm_Ensembl = ENSMUSG00000049382
| Mm_RefseqmRNA = NM_031170
| Mm_RefseqProtein = NP_112447
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101824745
| Mm_GenLoc_end = 101832348
| Mm_Uniprot = P11679
}}
}}
'''Keratin 8''', also known as '''KRT8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Moll R, Franke WW, Schiller DL, ''et al.'' |title=The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. |journal=Cell |volume=31 |issue= 1 |pages= 11-24 |year= 1983 |pmid= 6186379 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LHCGR... {November 6, 2007 4:44:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:44:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Luteinizing hormone/choriogonadotropin receptor
| HGNCid = 6585
| Symbol = LHCGR
| AltSymbols =; LHR; LCGR; LGR2; hLHR
| OMIM = 152790
| ECnumber =
| Homologene = 37276
| MGIid = 96783
| GeneAtlas_image1 = PBB_GE_LHCGR_207240_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004964 |text = lutropin-choriogonadotropic hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0030539 |text = male genitalia development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3973
| Hs_Ensembl = ENSG00000138039
| Hs_RefseqProtein = NP_000224
| Hs_RefseqmRNA = NM_000233
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 48768340
| Hs_GenLoc_end = 48836314
| Hs_Uniprot = P22888
| Mm_EntrezGene = 16867
| Mm_Ensembl = ENSMUSG00000024107
| Mm_RefseqmRNA = NM_013582
| Mm_RefseqProtein = NP_038610
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 88649875
| Mm_GenLoc_end = 88700302
| Mm_Uniprot = P30730
}}
}}
'''Luteinizing hormone/choriogonadotropin receptor''', also known as '''LHCGR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = LHCGR encodes the receptor for both luteinizing hormone and choriogonadotropin. Mutations in this gonadotropin receptor result in disorders of male secondary sexual character development, such as familial male precocious puberty and male pseudohermaphtoditism.<ref>{{cite web | title = Entrez Gene: LHCGR luteinizing hormone/choriogonadotropin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3973| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ji TH, Ryu KS, Gilchrist R, Ji I |title=Interaction, signal generation, signal divergence, and signal transduction of LH/CG and the receptor. |journal=Recent Prog. Horm. Res. |volume=52 |issue= |pages= 431-53; discussion 454 |year= 1997 |pmid= 9238862 |doi= }}
*{{cite journal | author=Dufau ML |title=The luteinizing hormone receptor. |journal=Annu. Rev. Physiol. |volume=60 |issue= |pages= 461-96 |year= 1998 |pmid= 9558473 |doi= 10.1146/annurev.physiol.60.1.461 }}
*{{cite journal | author=Ascoli M, Fanelli F, Segaloff DL |title=The lutropin/choriogonadotropin receptor, a 2002 perspective. |journal=Endocr. Rev. |volume=23 |issue= 2 |pages= 141-74 |year= 2002 |pmid= 11943741 |doi= }}
*{{cite journal | author=Amsterdam A, Hanoch T, Dantes A, ''et al.'' |title=Mechanisms of gonadotropin desensitization. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 69-74 |year= 2003 |pmid= 11988313 |doi= }}
*{{cite journal | author=Fanelli F, Puett D |title=Structural aspects of luteinizing hormone receptor: information from molecular modeling and mutagenesis. |journal=Endocrine |volume=18 |issue= 3 |pages= 285-93 |year= 2003 |pmid= 12450321 |doi= }}
*{{cite journal | author=Latronico AC, Segaloff DL |title=Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor. |journal=Mol. Cell. Endocrinol. |volume=260-262 |issue= |pages= 287-93 |year= 2007 |pmid= 17055147 |doi= 10.1016/j.mce.2005.11.053 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCOA3... {November 6, 2007 4:52:45 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NCOA3 image.jpg {November 6, 2007 4:54:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:55:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NCOA3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kbh.
| PDB = {{PDB2|1kbh}}
| Name = Nuclear receptor coactivator 3
| HGNCid = 7670
| Symbol = NCOA3
| AltSymbols =; RAC3; ACTR; AIB-1; AIB1; CAGH16; CTG26; MGC141848; SRC-1; SRC3; TNRC14; TNRC16; TRAM-1; pCIP
| OMIM = 601937
| ECnumber =
| Homologene = 4764
| MGIid = 1276535
| GeneAtlas_image1 = PBB_GE_NCOA3_207700_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCOA3_209060_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_NCOA3_209062_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0046966 |text = thyroid hormone receptor binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8202
| Hs_Ensembl = ENSG00000124151
| Hs_RefseqProtein = NP_006525
| Hs_RefseqmRNA = NM_006534
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 45564053
| Hs_GenLoc_end = 45717938
| Hs_Uniprot = Q9Y6Q9
| Mm_EntrezGene = 17979
| Mm_Ensembl = ENSMUSG00000027678
| Mm_RefseqmRNA = NM_008679
| Mm_RefseqProtein = NP_032705
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 165683882
| Mm_GenLoc_end = 165762141
| Mm_Uniprot = O09000
}}
}}
'''Nuclear receptor coactivator 3''', also known as '''NCOA3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.<ref>{{cite web | title = Entrez Gene: NCOA3 nuclear receptor coactivator 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8202| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Liao L, Kuang SQ, Yuan Y, ''et al.'' |title=Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. |journal=J. Steroid Biochem. Mol. Biol. |volume=83 |issue= 1-5 |pages= 3-14 |year= 2003 |pmid= 12650696 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTGS1... {November 6, 2007 4:46:18 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PTGS1 image.jpg {November 6, 2007 4:47:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:48:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PTGS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cqe.
| PDB = {{PDB2|1cqe}}, {{PDB2|1diy}}, {{PDB2|1ebv}}, {{PDB2|1eqg}}, {{PDB2|1eqh}}, {{PDB2|1fe2}}, {{PDB2|1ht5}}, {{PDB2|1ht8}}, {{PDB2|1igx}}, {{PDB2|1igz}}, {{PDB2|1pge}}, {{PDB2|1pgf}}, {{PDB2|1pgg}}, {{PDB2|1prh}}, {{PDB2|1pth}}, {{PDB2|1q4g}}, {{PDB2|1u67}}, {{PDB2|2ayl}}
| Name = Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
| HGNCid = 9604
| Symbol = PTGS1
| AltSymbols =; COX1; COX3; PCOX1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS
| OMIM = 176805
| ECnumber =
| Homologene = 743
| MGIid = 97797
| GeneAtlas_image1 = PBB_GE_PTGS1_215813_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTGS1_205127_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTGS1_205128_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004601 |text = peroxidase activity}} {{GNF_GO|id=GO:0004666 |text = prostaglandin-endoperoxide synthase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016702 |text = oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001516 |text = prostaglandin biosynthetic process}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5742
| Hs_Ensembl = ENSG00000095303
| Hs_RefseqProtein = NP_000953
| Hs_RefseqmRNA = NM_000962
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 124173050
| Hs_GenLoc_end = 124197802
| Hs_Uniprot = P23219
| Mm_EntrezGene = 19224
| Mm_Ensembl = ENSMUSG00000047250
| Mm_RefseqmRNA = NM_008969
| Mm_RefseqProtein = NP_032995
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 36052509
| Mm_GenLoc_end = 36074278
| Mm_Uniprot = Q3TJN9
}}
}}
'''Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)''', also known as '''PTGS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.<ref>{{cite web | title = Entrez Gene: PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5742| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Richards JA, Petrel TA, Brueggemeier RW |title=Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. |journal=J. Steroid Biochem. Mol. Biol. |volume=80 |issue= 2 |pages= 203-12 |year= 2002 |pmid= 11897504 |doi= }}
*{{cite journal | author=Jain S, Khuri FR, Shin DM |title=Prevention of head and neck cancer: current status and future prospects. |journal=Current problems in cancer |volume=28 |issue= 5 |pages= 265-86 |year= 2004 |pmid= 15375804 |doi= }}
*{{cite journal | author=Bingham S, Beswick PJ, Blum DE, ''et al.'' |title=The role of the cylooxygenase pathway in nociception and pain. |journal=Semin. Cell Dev. Biol. |volume=17 |issue= 5 |pages= 544-54 |year= 2007 |pmid= 17071117 |doi= 10.1016/j.semcdb.2006.09.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SDC1... {November 6, 2007 4:48:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:49:23 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Syndecan 1
| HGNCid = 10658
| Symbol = SDC1
| AltSymbols =; CD138; SDC; SYND1; syndecan
| OMIM = 186355
| ECnumber =
| Homologene = 2252
| MGIid = 1349162
| GeneAtlas_image1 = PBB_GE_SDC1_201286_at_tn.png
| GeneAtlas_image2 = PBB_GE_SDC1_201287_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008092 |text = cytoskeletal protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6382
| Hs_Ensembl = ENSG00000115884
| Hs_RefseqProtein = NP_001006947
| Hs_RefseqmRNA = NM_001006946
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 20264039
| Hs_GenLoc_end = 20288675
| Hs_Uniprot = P18827
| Mm_EntrezGene = 20969
| Mm_Ensembl = ENSMUSG00000020592
| Mm_RefseqmRNA = NM_011519
| Mm_RefseqProtein = NP_035649
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 8797404
| Mm_GenLoc_end = 8819683
| Mm_Uniprot = Q3THY2
}}
}}
'''Syndecan 1''', also known as '''SDC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.<ref>{{cite web | title = Entrez Gene: SDC1 syndecan 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6382| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=David G |title=Structural and functional diversity of the heparan sulfate proteoglycans. |journal=Adv. Exp. Med. Biol. |volume=313 |issue= |pages= 69-78 |year= 1992 |pmid= 1442271 |doi= }}
*{{cite journal | author=Jaakkola P, Jalkanen M |title=Transcriptional regulation of Syndecan-1 expression by growth factors. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=63 |issue= |pages= 109-38 |year= 1999 |pmid= 10506830 |doi= }}
*{{cite journal | author=Wijdenes J, Dore JM, Clement C, Vermot-Desroches C |title=CD138. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 2 |pages= 152-5 |year= 2003 |pmid= 12144130 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on THBD... {November 6, 2007 4:49:23 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein THBD image.jpg {November 6, 2007 4:50:25 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:50:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_THBD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1adx.
| PDB = {{PDB2|1adx}}, {{PDB2|1dqb}}, {{PDB2|1dx5}}, {{PDB2|1zaq}}, {{PDB2|2adx}}
| Name = Thrombomodulin
| HGNCid = 11784
| Symbol = THBD
| AltSymbols =; TM; CD141; THRM
| OMIM = 188040
| ECnumber =
| Homologene = 308
| MGIid = 98736
| GeneAtlas_image1 = PBB_GE_THBD_203887_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_THBD_203888_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0009790 |text = embryonic development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7056
| Hs_Ensembl = ENSG00000178726
| Hs_RefseqProtein = NP_000352
| Hs_RefseqmRNA = NM_000361
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 22974270
| Hs_GenLoc_end = 22978287
| Hs_Uniprot = P07204
| Mm_EntrezGene = 21824
| Mm_Ensembl = ENSMUSG00000074743
| Mm_RefseqmRNA = NM_009378
| Mm_RefseqProtein = NP_033404
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 148097654
| Mm_GenLoc_end = 148099387
| Mm_Uniprot = Q543W3
}}
}}
'''Thrombomodulin''', also known as '''THBD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.<ref>{{cite web | title = Entrez Gene: THBD thrombomodulin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7056| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Esmon CT |title=Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. |journal=FASEB J. |volume=9 |issue= 10 |pages= 946-55 |year= 1995 |pmid= 7615164 |doi= }}
*{{cite journal | author=Ohlin AK, Norlund L, Marlar RA |title=Thrombomodulin gene variations and thromboembolic disease. |journal=Thromb. Haemost. |volume=78 |issue= 1 |pages= 396-400 |year= 1997 |pmid= 9198186 |doi= }}
*{{cite journal | author=Van de Wouwer M, Collen D, Conway EM |title=Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 8 |pages= 1374-83 |year= 2005 |pmid= 15178554 |doi= 10.1161/01.ATV.0000134298.25489.92 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TSG101... {November 6, 2007 4:50:44 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TSG101 image.jpg {November 6, 2007 4:51:30 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 4:51:47 PM PST}
- CREATED: Created new protein page: TSG101 {November 6, 2007 4:51:56 PM PST}
- INFO: Beginning work on TYR... {November 6, 2007 4:51:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:52:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tyrosinase (oculocutaneous albinism IA)
| HGNCid = 12442
| Symbol = TYR
| AltSymbols =; OCA1A; OCAIA
| OMIM = 606933
| ECnumber =
| Homologene = 30969
| MGIid = 98880
| GeneAtlas_image1 = PBB_GE_TYR_206630_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004503 |text = monophenol monooxygenase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005798 |text = Golgi-associated vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042470 |text = melanosome}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006583 |text = melanin biosynthetic process from tyrosine}} {{GNF_GO|id=GO:0006726 |text = eye pigment biosynthetic process}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0043473 |text = pigmentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7299
| Hs_Ensembl = ENSG00000077498
| Hs_RefseqProtein = NP_000363
| Hs_RefseqmRNA = NM_000372
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 88550268
| Hs_GenLoc_end = 88668474
| Hs_Uniprot = P14679
| Mm_EntrezGene = 22173
| Mm_Ensembl = ENSMUSG00000004651
| Mm_RefseqmRNA = NM_011661
| Mm_RefseqProtein = NP_035791
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 87303166
| Mm_GenLoc_end = 87369172
| Mm_Uniprot = Q3UFK9
}}
}}
'''Tyrosinase (oculocutaneous albinism IA)''', also known as '''TYR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oetting WS, King RA |title=Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism. |journal=Hum. Mutat. |volume=13 |issue= 2 |pages= 99-115 |year= 1999 |pmid= 10094567 |doi= 10.1002/(SICI)1098-1004(1999)13:2<99::AID-HUMU2>3.0.CO;2-C }}
}}
{{refend}}
{{protein-stub}}
end log.
