User:Mr. Ibrahem/Venlafaxine

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Mr. Ibrahem/Venlafaxine
Clinical data
Pronunciation/ˌvɛnləˈfæksiːn/
Trade namesEffexor, Efexor, others[1]
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B2
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
Bioavailability42±15%[3]
Protein binding27±2% (parent compound), 30±12% (active metabolite, desvenlafaxine)[4]
MetabolismExtensively metabolised by the liver[3][4]
Elimination half-life5±2 h (parent compound for immediate release preparations), 15±6 h (parent compound for extended release preparations), 11±2 h (active metabolite)[3][4]
ExcretionKidney (87%; 5% as unchanged drug; 29% as desvenlafaxine and 53% as other metabolites)[3][4]
Identifiers
  • (RS)-1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]cyclohexanol
Chemical and physical data
FormulaC17H27NO2
Molar mass277.408 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • OC2(C(c1ccc(OC)cc1)CN(C)C)CCCCC2
  • InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 checkY
  • Key:PNVNVHUZROJLTJ-UHFFFAOYSA-N checkY
  (verify)

Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.[6] It is used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, and social phobia.[6] It may also be used for chronic pain.[7] It is taken by mouth.[6]

Common side effects include loss of appetite, constipation, dry mouth, dizziness, sweating, and sexual problems.[6] Severe side effects include an increased risk of suicide, mania, and serotonin syndrome.[6] Antidepressant withdrawal syndrome may occur if stopped.[6] There are concerns that use during the later part of pregnancy can harm the baby.[6] How it works is not entirely clear but it is believed to involve alterations in neurotransmitters in the brain.[6]

Venlafaxine was approved for medical use in the United States in 1993.[6] It is available as a generic medication.[6] In the United States the wholesale cost per dose is less than US$0.20 as of 2018.[8] In 2017, it was the 49th most commonly prescribed medication in the United States with more than 16 million prescriptions.[9][10]

References[edit]

  1. ^ Cite error: The named reference brands was invoked but never defined (see the help page).
  2. ^ "Efexor XL 75 mg hard prolonged release capsules - Summary of Product Characteristics (SmPC)". (emc). 16 March 2020. Archived from the original on 7 October 2020. Retrieved 15 April 2020.
  3. ^ a b c d "Apo-Venlafaxine XR Capsules" (PDF). TGA eBusiness Services. Macquarie Park, NSW: Apotex Pty Ltd. 13 April 2012. Archived from the original on 19 April 2018. Retrieved 6 November 2013.
  4. ^ a b c d "Venlafaxine (venlafaxine hydrochloride) tablet [Aurobindo Pharma Limited]". DailyMed. Aurobindo Pharma Limited. February 2013. Archived from the original on 30 January 2020. Retrieved 6 November 2013.
  5. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 7 November 2020. Retrieved 9 September 2020.
  6. ^ a b c d e f g h i j "Venlafaxine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Archived from the original on 27 November 2020. Retrieved 24 December 2018.
  7. ^ "Antidepressants: Another weapon against chronic pain". Mayo Clinic. Archived from the original on 26 October 2021. Retrieved 25 January 2020.
  8. ^ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services. Archived from the original on 19 December 2018. Retrieved 22 December 2018.
  9. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  10. ^ "Venlafaxine - Drug Usage Statistics". ClinCalc. Archived from the original on 29 November 2021. Retrieved 11 April 2020.
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