User:Mr. Ibrahem/Plerixafor

Mr. Ibrahem/Plerixafor
Clinical data
Trade names	Mozobil
Other names	JM 3100, AMD3100
AHFS/Drugs.com	Monograph
MedlinePlus	a609018
License data	EU EMA: by INN; US DailyMed: Plerixafor;
Pregnancy; category	AU: D; ;
Routes of; administration	Subcutaneous injection
Drug class	CXCR4 chemokine receptor blocker
Legal status
Legal status	US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	Up to 58%
Metabolism	None
Elimination half-life	3–5 hours
Excretion	Kidney
Identifiers
	IUPAC name 1,1’-(1,4-phenylenebismethylene)bis(1,4,8,11- tetraazacyclotetradecane);
Chemical and physical data
Formula	C28H54N8
Molar mass	502.796 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N1CCNCCCN(CCNCCC1)Cc2ccc(cc2)CN3CCCNCCNCCCNCC3;
	InChI InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2 ; Key:YIQPUIGJQJDJOS-UHFFFAOYSA-N ;
	(what is this?) (verify)

Plerixafor, sold under the brand name Mozobil, is a medication used to stimulate release of stem cells from the bone marrow into the blood to be collected for later transplanted back.^[3] It is used together with a granulocyte-colony stimulating factor (G-CSF).^[1] It is given by injection under the skin.^[1]

Common side effects include diarrhea, nausea, and pain at the site of injection.^[1] Other side effects may include low platelets, splenic rupture, and release of leukemia cells into the blood.^[2] Use in pregnancy may harm the baby.^[2] It works by blocking the activity of the CXCR4 chemokine receptor.^[1]

Plerixafor was approved for medical use in the United States in 2008 and Europe in 2009.^[2]^[1] In the United Kingdom a vial of 24 mg costs the NHS about £4,900 as of 2021.^[4] In the United States this amount costs about 9,300 USD.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Mozobil". Archived from the original on 23 July 2021. Retrieved 28 October 2021.
^ ^a ^b ^c ^d "Plerixafor Monograph for Professionals". Drugs.com. Archived from the original on 7 March 2016. Retrieved 28 October 2021.
^ Cite error: The named reference EAPR2021 was invoked but never defined (see the help page).
^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1079. ISBN 978-0857114105.
^ "Mozobil Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 18 April 2021. Retrieved 28 October 2021.

[EPAR2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Mozobil". Archived from the original on 23 July 2021. Retrieved 28 October 2021.

[AHFS2021-2] "Plerixafor Monograph for Professionals". Drugs.com. Archived from the original on 7 March 2016. Retrieved 28 October 2021.

[EAPR2021-3] Cite error: The named reference EAPR2021 was invoked but never defined (see the help page).

[BNF81-4] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1079. ISBN 978-0857114105.

[5] "Mozobil Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 18 April 2021. Retrieved 28 October 2021.

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