User:Mr. Ibrahem/Pentoxifylline
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| Pronunciation | /ˌpɛntɒkˈsɪfɪliːn, -ɪn/ |
| Trade names | Pentoxil, Trental, others[1] |
| Other names | Oxpentifylline (former AAN)[2] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a685027 |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | 10–30%[3] |
| Metabolism | Liver and via erythrocytes |
| Elimination half-life | 0.4–0.8 hours (1–1.6 hours for active metabolite)[3] |
| Excretion | Urine (95%), faeces (<4%)[3] |
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| Chemical and physical data | |
| Formula | C13H18N4O3 |
| Molar mass | 278.312 g·mol−1 |
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Pentoxifylline, also known as oxpentifylline, is a medication used to treat peripheral artery disease that results in pain with walking and venous leg ulcers.[4] There is tentative evidence that it may improve peoples ability to walk.[5] Use is not recommended in the United Kingdom.[4] It is taken by mouth.[6]
Common side effects include nausea, dizziness, and heart burn.[6] Other side effects may include bleeding.[4] It is a xanthine derivative and is believed to work by increasing red blood cell flexibility.[6]
Pentoxifylline was approved for medical use in the United States in 1984.[6] It is available as a generic medication.[6] In the United Kingdom it costs the NHS about £19 a month as of 2021.[4] This amount in the United States is about 36 USD.[7]
References[edit]
- ^ Drugs.com drugs.com international listings for Pentoxifylline Archived 2020-09-25 at the Wayback Machine. Page accessed Feb 1, 206
- ^ "PRODUCT INFORMATION TRENTAL® 400" (PDF). TGA eBusiness Services. sanofi-aventis australia pty limited. 25 March 2010. Archived from the original on 9 August 2017. Retrieved 3 February 2014.
- ^ a b c "Trental, Pentoxil (pentoxifylline) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 4 February 2014. Retrieved 3 February 2014.
- ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 250. ISBN 978-0857114105.
- ^ Broderick, Cathryn; Forster, Rachel; Abdel-Hadi, Mohammed; Salhiyyah, Kareem (October 16, 2020). "Pentoxifylline for intermittent claudication". The Cochrane Database of Systematic Reviews. 10: CD005262. doi:10.1002/14651858.CD005262.pub4. ISSN 1469-493X. PMC 8094235. PMID 33063850.
{{cite journal}}: CS1 maint: PMC embargo expired (link) - ^ a b c d e "Pentoxifylline Monograph for Professionals". Drugs.com. Archived from the original on 18 June 2019. Retrieved 27 October 2021.
- ^ "Pentoxifylline Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 January 2021. Retrieved 27 October 2021.