User:Mr. Ibrahem/Lomustine

Mr. Ibrahem/Lomustine
Clinical data
Trade names	CeeNU, Gleostine, CCNU, others
Other names	1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
AHFS/Drugs.com	Monograph
MedlinePlus	a682207
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth (capsules)
Drug class	Alkylating agent
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	~100%
Protein binding	50%
Metabolism	Liver
Metabolites	Monoxydroxylated metabolites, trans-4-hydroxy-CCNU, cis-4-hydroxy-CCNU
Elimination half-life	16–48 hours (metabolites)
Identifiers
	IUPAC name N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea;
Chemical and physical data
Formula	C9H16ClN3O2
Molar mass	233.70 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	90 °C (194 °F)
	SMILES O=C(NC1CCCCC1)N(N=O)CCCl;
	InChI InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14) ; Key:GQYIWUVLTXOXAJ-UHFFFAOYSA-N ;
	(what is this?) (verify)

Lomustine sold under the brand name CeeNU, is a medication used to treat brain tumors, melanoma, and Hodgkin lymphoma (HL).^[1]^[3] In HL it is used when other treatments have not worked.^[1] It is taken by mouth.^[1]

Common side effects include pulmonary fibrosis, low platelets, low white blood cells, low red blood cells, nausea, kidney problems, and liver problems.^[1] Other side effects may include hair loss, confusion, vision loss, and mouth inflammation.^[3] It should not be used in pregnancy or breastfeeding.^[3] It is an alkylating nitrosourea compound.^[1]

Lomustine was approved for medical use in the United States in 1976.^[1] It is available as a generic medication.^[3] In the United States it costs about 1,050 USD per 100 mg pill as of 2021.^[4] This amount in the United Kingdom costs the NHS about £50.^[3]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Lomustine Monograph for Professionals". Drugs.com. Archived from the original on 17 August 2019. Retrieved 24 November 2021.
^ Lee FY, Workman P, Roberts JT, Bleehen NM (1985). "Clinical pharmacokinetics of oral CCNU (lomustine)". Cancer Chemotherapy and Pharmacology. 14 (2): 125–31. doi:10.1007/bf00434350. PMID 3971475. S2CID 29619378.
^ ^a ^b ^c ^d ^e ^f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 941. ISBN 978-0857114105.
^ "Gleostine Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 24 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Lomustine Monograph for Professionals". Drugs.com. Archived from the original on 17 August 2019. Retrieved 24 November 2021.

[2] Lee FY, Workman P, Roberts JT, Bleehen NM (1985). "Clinical pharmacokinetics of oral CCNU (lomustine)". Cancer Chemotherapy and Pharmacology. 14 (2): 125–31. doi:10.1007/bf00434350. PMID 3971475. S2CID 29619378.

[BNF81-3] ^ ^a ^b ^c ^d ^e ^f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 941. ISBN 978-0857114105.

[4] "Gleostine Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 24 November 2021.

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