User:Mr. Ibrahem/Ivacaftor

From Wikipedia, the free encyclopedia

Mr. Ibrahem/Ivacaftor
Clinical data
Trade namesKalydeco
Other namesVX-770
AHFS/Drugs.comMonograph
MedlinePlusa612012
License data
Pregnancy
category
Routes of
administration		By mouth
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only[2]
  • EU: Rx-only[3]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding99%
MetabolismCYP3A
Elimination half-life12 hrs (single dose)
Excretion88% faeces
Identifiers
  • N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
Chemical and physical data
FormulaC24H28N2O3
Molar mass392.499 g·mol−1
3D model (JSmol)
  • O= C\2c1c(cccc1)N/C= C/2C(= O)Nc3cc(O)c(cc3C(C)(C)C)C(C)(C)C
  • InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29) checkY
  • Key:PURKAOJPTOLRMP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ivacaftor, sold under the brand name Kalydeco, is a medication used to treat cystic fibrosis.[3] Specifically it is used for cases that have specific mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.[3] It is taken by mouth.[4]

Common side effects include headache, throat pain, runny nose, abdominal pain, diarrhea, rash, and nausea.[5] Other side effects may include liver problems.[5] There is no evidence of harm in pregnancy, but such use has not been well studied.[6] It works by increasing the effectiveness of CFTR.[3]

Ivacaftor was approved for medical use in the United States and Europe in 2012.[5][3] In the United Kingdom a year of treatment costs the NHS about £196,000 as of 2021.[4] In the United States this amount costs about 350,000 USD.[7] It is also available in combination as lumacaftor/ivacaftor, tezacaftor/ivacaftor, and elexacaftor/tezacaftor/ivacaftor.[4]

References[edit]

  1. ^ a b "Ivacaftor (Kalydeco) Use During Pregnancy". Drugs.com. 9 November 2019. Archived from the original on 21 October 2020. Retrieved 26 June 2020.
  2. ^ "Kalydeco- ivacaftor tablet, film coated Kalydeco- ivacaftor granule prescribing information". DailyMed. 25 April 2019. Archived from the original on 28 September 2020. Retrieved 20 November 2019.
  3. ^ a b c d e "Kalydeco". Archived from the original on 21 November 2019. Retrieved 1 December 2021.
  4. ^ a b c d e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 310. ISBN 978-0857114105.
  5. ^ a b c d "Ivacaftor Monograph for Professionals". Drugs.com. Archived from the original on 6 May 2021. Retrieved 26 November 2021.
  6. ^ "Ivacaftor (Kalydeco) Use During Pregnancy". Drugs.com. Archived from the original on 21 October 2020. Retrieved 1 December 2021.
  7. ^ "Kalydeco Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 July 2021. Retrieved 1 December 2021.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Ivacaftor&oldid=1109966094"