User:Mr. Ibrahem/Imipramine

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Mr. Ibrahem/Imipramine
Clinical data
Trade namesTofranil, Tofranil-PM, others
Other namesImipramine hydrochloride, melipramine; G-22355
AHFS/Drugs.comMonograph
MedlinePlusa682389
License data
Pregnancy
category
Routes of
administration		By mouth, intramuscular injection
Drug classTricyclic antidepressant (TCA)[2]
Legal status
Legal status
Pharmacokinetic data
Bioavailability94–96%[3]
Protein binding86%[4]
MetabolismLiver (CYP1A2, CYP2C19, CYP2D6)[4]
MetabolitesDesipramine[4]
Elimination half-life20 hours[4]
ExcretionKidney (80%), fecal (20%)[4]
Identifiers
  • 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
Chemical and physical data
FormulaC19H24N2
Molar mass280.415 g·mol−1
3D model (JSmol)
  • CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
  • InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 checkY
  • Key:BCGWQEUPMDMJNV-UHFFFAOYSA-N checkY
  (verify)

Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) used to treat depression, anxiety disorders including panic disorder, bed wetting, and postherpetic neuralgia.[5][2] It is taken by mouth.[2]

Common side effects include dry mouth, sleepiness, constipation, blurry vision, and low blood pressure with standing.[2] Other side effects may include mania, sunburns, seizures, and suicide.[2] Safety in pregnancy is unclear.[6] How it works is not clear but may involve increasing levels of serotonin and norepinephrine.[2]

Imipramine was discovered in 1951 and came into medical use in 1959.[7] It was the first TCA to be marketed.[8] It is available as a generic medication. In the United Kingdom 4 weeks of 25 mg costs the NHS about £7 as of 2021.[5] This amount in the United States is about 10 USD.[9]

References[edit]

  1. ^ a b "Imipramine Use During Pregnancy". Drugs.com. 28 August 2019. Archived from the original on 7 February 2020. Retrieved 7 February 2020.
  2. ^ a b c d e f g h "Imipramine Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 26 November 2021.
  3. ^ Heck HA, Buttrill SE Jr, Flynn NW, Dyer RL, Anbar M, Cairns T, Dighe S, Cabana BE (June 1979). "Bioavailability of imipramine tablets relative to a stable isotope-labelled internal standard: increasing the power of bioavailability tests". Journal of Pharmacokinetics and Biopharmaceutics. 7 (3): 233–248. doi:10.1007/bf01060015. PMID 480146. S2CID 23232584.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ a b c d e "Product Information Tolerade (imipramine hydrochloride)". TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013. Archived from the original on 10 December 2019. Retrieved 16 October 2013.
  5. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 397. ISBN 978-0857114105.
  6. ^ "Imipramine Use During Pregnancy". Drugs.com. Archived from the original on 7 February 2020. Retrieved 26 November 2021.
  7. ^ Walker, S. R. (6 December 2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109. ISBN 978-94-009-2659-2. Archived from the original on 14 September 2016. Retrieved 26 November 2021.
  8. ^ "imipramine | Uses, Mechanism of Action, & Side Effects | Britannica". www.britannica.com. Archived from the original on 8 November 2021. Retrieved 26 November 2021.
  9. ^ "Imipramine Hydrochloride Prices and Imipramine Hydrochloride Coupons - GoodRx". GoodRx. Retrieved 26 November 2021.
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