User:Mr. Ibrahem/Hyoscyamine

Mr. Ibrahem/Hyoscyamine
Clinical data
Trade names	Anaspaz, Levbid, Levsin, others
Other names	Hyoscyamine sulfate, daturine, duboisine
AHFS/Drugs.com	Monograph
MedlinePlus	a684010
Pregnancy; category	C (US);
Routes of; administration	By mouth, injection
Drug class	Antispasmodics (antimuscarinic)
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	50% protein binding
Metabolism	Hepatic
Elimination half-life	3–5 hrs.
Excretion	Urine
Identifiers
	IUPAC name (S)-(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate;
Chemical and physical data
Formula	C17H23NO3
Molar mass	289.375 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN3[C@H]1CC[C@@H]3C[C@@H](C1)OC(=O)[C@H](CO)c2ccccc2;
	InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16-/m1/s1 ; Key:RKUNBYITZUJHSG-FXUDXRNXSA-N ;
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Hyoscyamine, sold under the brand name Anaspaz among others, is a medication used to treat irritable bowel syndrome, decrease saliva production, and treat cholinesterase inhibitor toxicity.^[1] Evidence for infant colic is poor.^[1] It may be taken by mouth or given by injection.^[1]

Side effects may include dry mouth, urinary retention, blurry vision, palpitations, headache, anxiety, sleepiness, rash, and poor coordination.^[1] Other side effects may include psychosis and glaucoma.^[1] It is an antispasmodics or the antimuscarinic type.^[1]

Hyoscyamine was initially isolated in 1833 from henbane.^[2] It is available as a generic medication under a number of brands.^[3] In the United States 30 tablets of 0.125 mg costs less than 10 USD as of 2021.^[3]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Hyoscyamine Monograph for Professionals". Drugs.com. Archived from the original on 24 November 2021. Retrieved 10 December 2021.
^ Anderson, Kenneth (25 July 2021). Strychnine & Gold (Part 2): Volume One Part Two of the Untold History of Addiction Treatment in the United States. Independently published. p. 321. ISBN 979-8-5380-3154-2. Archived from the original on 11 December 2021. Retrieved 10 December 2021.
^ ^a ^b "Hyoscyamine Prices and Hyoscyamine Coupons - GoodRx". GoodRx. Archived from the original on 23 April 2019. Retrieved 10 December 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Hyoscyamine Monograph for Professionals". Drugs.com. Archived from the original on 24 November 2021. Retrieved 10 December 2021.

[2] Anderson, Kenneth (25 July 2021). Strychnine & Gold (Part 2): Volume One Part Two of the Untold History of Addiction Treatment in the United States. Independently published. p. 321. ISBN 979-8-5380-3154-2. Archived from the original on 11 December 2021. Retrieved 10 December 2021.

[GX2021-3] "Hyoscyamine Prices and Hyoscyamine Coupons - GoodRx". GoodRx. Archived from the original on 23 April 2019. Retrieved 10 December 2021.

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