User:Mr. Ibrahem/Galantamine

Mr. Ibrahem/Galantamine
Clinical data
Trade names	Razadyne, Reminyl, GalantaMind, others
Other names	Galantamine hydrobromide
AHFS/Drugs.com	Monograph
MedlinePlus	a699058
License data	US DailyMed: Razadyne;
Pregnancy; category	AU: B1; ;
Routes of; administration	By mouth
Drug class	Anticholinesterase inhibitor
Legal status
Legal status	EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	80–100%
Protein binding	18%
Metabolism	Liver partially CYP450:CYP2D6/3A4 substrate
Elimination half-life	7 hours
Excretion	Kidney (95%, of which 32% unchanged), fecal (5%)
Identifiers
	IUPAC name (4aS,6R,8aS)-5,6,9,10,11,12-Hexahydro-3-methoxy-11-methyl-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol;
Chemical and physical data
Formula	C17H21NO3
Molar mass	287.359 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	126.5 °C (259.7 °F)
	SMILES O(c2c1O[C@H]4C[C@@H](O)/C=C\[C@@]43c1c(cc2)CN(C)CC3)C;
	InChI InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1 ; Key:ASUTZQLVASHGKV-JDFRZJQESA-N ;
	(verify)

Galantamine, sold under the brand name Razadyne among others, is a medication used to treat mild to moderate Alzheimer's disease.^[4]^[5] It may be used in dementia with Lewy bodies if other treatments are not tolerated.^[2] In mild cognitive impairment it may worsen outcomes.^[4] It is taken by mouth.^[4]

Common side effect include arrhythmias, depression, diarrhea, sleepiness, hallucinationss, high blood pressure, and tremor.^[2] Other side effects may include gastrointestinal bleeding, urinary retention, seizures, and Stevens-Johnson syndrome.^[4] It is an anticholinesterase inhibitor which increases acetylcholine at cholinergic synapses in the brain.^[2]^[4]

Galantamine was approved for medical use in the United States in 2001.^[4] It is available as a generic medication.^[2] In the United Kingdom it costs the NHS up to £80 for 4 weeks as of 2021.^[2] This amount in the United States costs about 66 USD.^[6]

References[edit]

^ ^a ^b "Galantamine Use During Pregnancy". Drugs.com. 18 February 2019. Archived from the original on 25 February 2020. Retrieved 24 February 2020.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 318. ISBN 978-0857114105.
^ "Archive copy" (PDF). Archived (PDF) from the original on 2021-10-31. Retrieved 2021-09-26.{{cite web}}: CS1 maint: archived copy as title (link)
^ ^a ^b ^c ^d ^e ^f ^g "Galantamine Monograph for Professionals". Drugs.com. Archived from the original on 19 October 2021. Retrieved 2 December 2021.
^ Birks J (January 2006). Birks JS (ed.). "Cholinesterase inhibitors for Alzheimer's disease". The Cochrane Database of Systematic Reviews (1): CD005593. doi:10.1002/14651858.CD005593. PMID 16437532.
^ "Galantamine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 October 2021. Retrieved 2 December 2021.

[Drugs.com_pregnancy-1] "Galantamine Use During Pregnancy". Drugs.com. 18 February 2019. Archived from the original on 25 February 2020. Retrieved 24 February 2020.

[BNF81-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 318. ISBN 978-0857114105.

[3] "Archive copy" (PDF). Archived (PDF) from the original on 2021-10-31. Retrieved 2021-09-26.{{cite web}}: CS1 maint: archived copy as title (link)

[AHFS2021-4] ^ ^a ^b ^c ^d ^e ^f ^g "Galantamine Monograph for Professionals". Drugs.com. Archived from the original on 19 October 2021. Retrieved 2 December 2021.

[Birk2006-5] Birks J (January 2006). Birks JS (ed.). "Cholinesterase inhibitors for Alzheimer's disease". The Cochrane Database of Systematic Reviews (1): CD005593. doi:10.1002/14651858.CD005593. PMID 16437532.

[6] "Galantamine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 October 2021. Retrieved 2 December 2021.

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