User:Mr. Ibrahem/Famotidine

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Mr. Ibrahem/Famotidine
Clinical data
Pronunciation/fəˈmɒtɪdiːn/
Trade namesPepcid, others
AHFS/Drugs.comMonograph
MedlinePlusa687011
License data
Pregnancy
category
  • AU: B1
Routes of
administration		By mouth (tablets), Intravenous
Legal status
Legal status
Pharmacokinetic data
Bioavailability40–45% (by mouth)[1]
Protein binding15–20%[1]
Metabolismhepatic
Elimination half-life2.5–3.5 hours[1]
ExcretionKidney (25–30% unchanged [Oral])[1]
Identifiers
  • 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N-sulfamoylpropanimidamide
Chemical and physical data
FormulaC8H15N7O2S3
Molar mass337.44 g·mol−1
3D model (JSmol)
  • NS(=O)(=O)/N=C(\N)CCSCc1csc(n1)N=C(N)N
  • InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14) checkY
  • Key:XUFQPHANEAPEMJ-UHFFFAOYSA-N checkY
  (verify)

Famotidine, sold under the brand name Pepcid among others, is a medication that decreases stomach acid production.[3] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome.[3] It is taken by mouth or by injection into a vein.[3] It begins working within an hour.[3]

Common side effects include headache, intestinal upset, and dizziness.[3] Serious side effects may include pneumonia and seizures.[3][4] Use in pregnancy appears safe but has not been well studied while use during breastfeeding is not recommended.[5] It is a histamine H2 receptor antagonist.[3]

Famotidine was patented in 1979 and came into medical use in 1985.[6] It is available as a generic medication.[4] A month supply in the United Kingdom costs the NHS about £30 as of 2019.[4] In the United States the wholesale cost of this amount is about $2.[7] In 2017, it was the 115th most commonly prescribed medication in the United States, with more than six million prescriptions.[8][9]

References[edit]

  1. ^ a b c d Truven Health Analytics, Inc. DRUGDEX® System (Internet) [cited 2013 Oct 10]. Greenwood Village, CO: Thomsen Healthcare; 2013.
  2. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 5 September 2020.
  3. ^ a b c d e f g "Famotidine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  4. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 74–75. ISBN 9780857113382.
  5. ^ "Famotidine Use During Pregnancy". Drugs.com. Retrieved 3 March 2019.
  6. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 444. ISBN 9783527607495. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  7. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  8. ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  9. ^ "Famotidine - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
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