User:Mr. Ibrahem/Cimetidine

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Mr. Ibrahem/Cimetidine
Clinical data
Pronunciation/sɪˈmɛtɪdiːn/ or /saɪˈmɛtɪdiːn/
Trade namesTagamet, others[1]
Other namesSKF-92334[2]
AHFS/Drugs.comMonograph
MedlinePlusa682256
License data
Pregnancy
category
  • AU: B1
Routes of
administration		By mouth, intramuscular injection, intravenous infusion[3]
Drug classH2 receptor antagonist[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only (although 200 mg is OTC)
Pharmacokinetic data
Bioavailability60–70%[4][5]
Protein binding13–25%[5][6]
MetabolismLiver[5]
Metabolites• Cimetidine sulfoxide[5]
• Hydroxycimetidine[5]
• Guanyl urea cimetidine[5]
Onset of action30 minutes[7]
Elimination half-life123 minutes (~2 hours)[6]
Duration of action4–8 hours[3]
ExcretionUrine[6]
Identifiers
  • 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
Chemical and physical data
FormulaC10H16N6S
Molar mass252.34 g·mol−1
3D model (JSmol)
  • CC1=C(N=CN1)CSCCNC(=NC)NC#N
  • InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) checkY
  • Key:AQIXAKUUQRKLND-UHFFFAOYSA-N checkY
  (verify)

Cimetidine, sold under the brand name Tagamet among others, is a medication used to treat stomach ulcers, gastroesophageal reflux disease (GERD), heart burn, and upper GI bleeding.[8][9] It may also be used for allergic reactions.[9] It is taken by mouth or by injection.[9] Onset is within an hour with effects lasting for up to 5 hours.[10]

Common side effects include dizziness, headache, sleepiness, and diarrhea.[9] Prolonged use may result in breast enlargement.[9] Other side effects may include arrythmias, pneumonia, and confusion.[9] There is no evidence of harm in pregnancy, but such use has not been well studied.[11] H2 receptor antagonist that inhibits stomach acid production.[1]

Cimetidine was developed in 1971 and came into commercial use in 1977.[12][13] It is available as a generic medication.[8] In the United Kingdom a month of medication costs the NHS about £16 as of 2021.[8] This amount in the United States is about 33 USD.[14]

References[edit]

  1. ^ a b c Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 234–. ISBN 978-3-88763-075-1. Archived from the original on 2020-07-29. Retrieved 2021-10-04.
  2. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Bibliographies. Springer. pp. 275–. ISBN 978-1-4757-2085-3. Archived from the original on 29 July 2020. Retrieved 4 October 2021.
  3. ^ a b Anita Gupta; Nina Singh-Radcliff (12 March 2013). Pharmacology in Anesthesia Practice. Oxford University Press. pp. 177–. ISBN 978-0-19-934399-7. Archived from the original on 2 November 2021. Retrieved 4 October 2021.
  4. ^ Frank J. Dowd; Bart Johnson; Angelo Mariotti (3 September 2016). Pharmacology and Therapeutics for Dentistry - E-Book. Elsevier Health Sciences. pp. 406–. ISBN 978-0-323-44595-5. Archived from the original on 2 November 2021. Retrieved 4 October 2021.
  5. ^ a b c d e f Jerrold B. Leikin; Frank P. Paloucek (1995). Poisoning & Toxicology Handbook, 1995-1996. Lexi-Comp, Incorporated. p. 184. ISBN 978-0-916589-08-0. Archived from the original on 2021-11-02. Retrieved 2021-10-04.
  6. ^ a b c Profiles of Drug Substances, Excipients and Related Methodology. Academic Press. 24 October 1984. pp. 176–. ISBN 978-0-08-086108-1. Archived from the original on 2 November 2021. Retrieved 4 October 2021.
  7. ^ Vallerand AH, Sanoski CA, Deglin JH (25 May 2016). Davis's Drug Guide for Nurses. F.A. Davis. pp. 636–. ISBN 978-0-8036-5779-3.
  8. ^ a b c d e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 80. ISBN 978-0857114105.
  9. ^ a b c d e f g h "Cimetidine Monograph for Professionals". Drugs.com. Archived from the original on 16 November 2021. Retrieved 5 January 2022.
  10. ^ RN, Linda Lane Lilley, PhD; PharmD, Shelly Rainforth Collins; RN-BC, Julie S. Snyder, MSN (15 December 2015). Pharmacology and the Nursing Process. Elsevier Health Sciences. p. 806. ISBN 978-0-323-35828-6. Archived from the original on 11 January 2022. Retrieved 5 January 2022.{{cite book}}: CS1 maint: multiple names: authors list (link)
  11. ^ "Cimetidine Use During Pregnancy". Drugs.com. Archived from the original on 4 December 2020. Retrieved 5 January 2022.
  12. ^ Fischer J, Ganellin CR (24 August 2010). Analogue-based Drug Discovery II. John Wiley & Sons. p. 4. ISBN 978-3-527-63212-1. Archived from the original on 29 July 2020. Retrieved 4 October 2021.
  13. ^ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 444. ISBN 9783527607495. Archived from the original on 2020-07-29. Retrieved 2021-10-04.
  14. ^ "Cimetidine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 December 2021. Retrieved 5 January 2022.
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