User:Mr. Ibrahem/Adenosine
Clinical data | |
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Trade names | Adenocard; Adenocor; Adenic; Adenoco; Adeno-Jec; Adenoscan; Adenosin; Adrekar; Krenosin |
Other names | SR-96225 |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | Rapidly cleared from circulation via cellular uptake |
Protein binding | No |
Metabolism | Rapidly converted to inosine and adenosine monophosphate |
Onset of action | <40 sec[1] |
Elimination half-life | cleared plasma <30 seconds; half-life <10 seconds |
Duration of action | 1 to 2 min[1] |
Excretion | can leave cell intact or can be degraded to hypoxanthine, xanthine, and ultimately uric acid |
Identifiers | |
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Chemical and physical data | |
Formula | C10H13N5O4 |
Molar mass | 267.245 g·mol−1 |
3D model (JSmol) | |
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Adenosine is a chemical found in mammals which is also used as a medication.[3][4] As a medication it is used to treat or diagnosis certain forms of supraventricular tachycardia that do not improve with vagal maneuvers.[2] It is generally used by rapid injection into a vein.[2] Onset of action is within 40 seconds and effects last for less than 2 minutes.[1]
Common side effects include chest pain, feeling faint, shortness of breath, and tingling of the skin.[2] Serious side effects include a worsening dysrhythmia and low blood pressure.[2] While it may be used during pregnancy, safety is not entirely clear.[5] Adenosine is one of four nucleoside building blocks to RNA.[3] It works by decreasing the frequency by which electrical signals can go through the AV node of the heart.[2]
Adenosine was approved for medical use in the United States in 1989.[2] It; however, has been studied within living systems since the 1920s.[3] Adenosine is avaliable as a generic medication.[6] It is not expensive.[7] In the United Kingdom in 2020 a 6 mg dose costs the NHS about a pound.[6]
References[edit]
- ^ a b c d Aehlert, Barbara J. (2015). ECGs Made Easy - E-Book. Elsevier Health Sciences. p. 116. ISBN 978-0-323-39150-4. Archived from the original on 27 August 2021. Retrieved 29 September 2020.
- ^ a b c d e f g h "Adenosine". The American Society of Health-System Pharmacists. Archived from the original on December 23, 2014. Retrieved Sep 27, 2020.
- ^ a b c Adenosine Receptors in Neurology and Psychiatry. Academic Press. 2014. p. XV. ISBN 978-0-12-801318-2. Archived from the original on 2021-08-27. Retrieved 2020-09-28.
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 18–. ISBN 978-3-88763-075-1. Archived from the original on 2016-05-04. Retrieved 2016-01-05.
- ^ "Adenosine Use During Pregnancy". Drugs.com. Archived from the original on 5 December 2020. Retrieved 28 September 2020.
- ^ a b BNF 79. London: Pharmaceutical Press. March 2020. p. 110. ISBN 978-0857113658.
- ^ Hitchings, Andrew; Lonsdale, Dagan; Burrage, Daniel; Baker, Emma (2019). The Top 100 Drugs: Clinical Pharmacology and Practical Prescribing (2nd ed.). Elsevier. pp. 34–35. ISBN 978-0-7020-7442-4. Archived from the original on 2021-05-22. Retrieved 2021-11-09.