Talk:Zinc pyrithione

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Zinc pyrithione.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Wiki Education Foundation-supported course assignment[edit]

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): XiaoMMMZhao.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 05:29, 18 January 2022 (UTC)[reply]

Monomeric vs dimeric form[edit]

The stick-figure is a monomer but the 3D-balls is a dimer. Both are known forms, but should be consistent in the infobox (probably monomer, since that's the molecular compound itself?). Monomeric vs dimeric is important for bioactivity and presumably chemistry, and solubility and other properties. Lead refs:

"The influence of chemical composition on anti-bacterial activity. VIII. 2-Mercaptopyridine-N-oxide, and some general observations on metal-binding agents". Br. J. Exp. Pathol. 37: 5000–5001. 1956. {{cite journal}}: Cite uses deprecated parameter |authors= (help)

"Mechanism of Pyrithione-Induced Membrane Depolarization in Neurospora crassa". Applied and Environmental Microbiology. 61 (9): 3385–3390. 1995. {{cite journal}}: Cite uses deprecated parameter |authors= (help); Unknown parameter |month= ignored (help)

"Structural characterization of bis(N-oxopyridine-2-thionato)zinc(II)". Inorg. Chem. 16 (8): 1834–1838. 1977. doi:10.1021/ic50174a002. {{cite journal}}: Cite uses deprecated parameter |authors= (help)

"Pyrithione biocide interactions with bacterial phospholipid head groups". Journal of Applied Microbiology. 85 (1): 132–140. doi:10.1046/j.1365-2672.1998.00477.x.

DMacks (talk) 17:25, 28 August 2008 (UTC)[reply]

That's fine, I'm happy to make a similar ball-and-stick model of the monomer, but do any of these articles (or any others) contain detailed structural data on the monomer? For example, square planar or tetrahedral? I'd assume tetrahedral, but I wouldn't want to put false information out there!

Ben (talk) 22:32, 28 August 2008 (UTC)[reply]

I did not see any ref to monomer X-ray, so you're out of luck. There's a good chance that the monomer has bound solvent, which complicates matters further. The situation is like the zinc acac's.--Smokefoot (talk) 23:03, 28 August 2008 (UTC)[reply]

Much of the infobox data is also about the monomeric form (formula & weight, for example). The Chemspider page agrees with the monomeric, and the pubchem as well (and the pubchem entry even asserts that it's a dication!). Note also confusion between monomeric one-ligand vs two-ligand also. DMacks (talk) 17:02, 15 December 2010 (UTC)[reply]

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Justify the Health Effects[edit]

It would be nice to specify the responses that has been mentioned in the session of "Health Effects". Here are notes taken from the Reference 8: Zinc pyrithione at a nanomolar concentration triggers cellular responses after a 24-hour treatment. Zinc pyrithione induces DNA damage and cell apoptosis of primary skin cells. Zinc pyrithione reduces the ATP energy source of primary skin cells.^[1]

References

^ Lamore, Sarah; Cabello, Christopher; Wondrak, Georg (Oct 7, 2009). "The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in cultured human skin cells". Cell Stress Chaperones. 13 (3): 309–322. doi:10.1007/s12192-009-0145-6. PMID 19809895.

XiaoMMMZhao (talk) 16:58, 18 October 2016 (UTC)[reply]

We just dont talk about health effects (for humans) unless we have super good references. The rule is WP:MEDRS. And furthermore, we try to avoid primary references like the one cite above. That rule is described in WP:SECONDARY. --Smokefoot (talk) 18:09, 18 October 2016 (UTC)[reply]

There is a lack of secondary source about zinc pyrithione use in cancer. Does it mean I cannot add any information about it into the page?XiaoMMMZhao (talk) 15:15, 20 October 2016 (UTC)[reply]

exactly. Jytdog (talk) 01:09, 21 October 2016 (UTC)[reply]

Indeed" you cannot add any information about it into the page". Also be sure to avoid WP:COI, which states that citations to you, your colleagues, or your friends should ordinarily be avoided. --Smokefoot (talk) 02:16, 21 October 2016 (UTC)[reply]

Mechanism of Action[edit]

The anti-algae effect of zinc pyrithione is associated with the inhibition of algae photosynthesis.^[1]

References

^ Qian, Pei-Yuan; Chen, Lianguo; Xu, Ying (Apr 10, 2013). "Mini-review: Molecular mechanisms of antifouling compounds". Biofouling. 29 (4): 392, 393. doi:10.1080/08927014.2013.776546.

-- XiaoMMMZhao (talk) 00:54, 19 October 2016 (UTC)[reply]

that's great. nice ref. Jytdog (talk) 01:10, 19 October 2016 (UTC)[reply]

Evaluation[edit]

The lead section is not clear. 1) Zinc pyrithione is a coordination complex of zinc salt and pyrithione salt. 2) As mentioned in the body of text, zinc pyrithione has been applied in shampoo for many years. This information should be included in the leading section. 3) The emphasis of the use of zinc pyrithione in seborrheic dermatitis is not appropriate.

Structure of the page is not good enough. Session #3 is a mechanism specific for the use of zinc pyrithione in antifungal treatments. Session #4 is specific for the use of zinc pyrithione in shampoo. Session #3 and #4 should be included in the session #2.1.

The topics are not balanced well. 1) Session #1 should include the synthesis of zinc pyrithione that has been patterned once in industry. Audiences may want to know about the copyright of zinc pyrithione. 2) Referring to session #4, is zinc pyrithione only approved in the United States for anti-dandruff treatments? Were the variety of responses triggered by zinc pyrithione good or bad for human health? 3) The information is not enough about using zinc pyrithione in sponges.

The coverage is not neutral enough. 1) Session #2.3 and #4.1 look like advertisements of particular brands. 2) The external link of toxicity does not provide the toxicity of zinc pyrithione in carcinogen, ground water contaminant, and endocrine disruptor. Why not find literature to support the missing information? 3) Several words are not neutral. For example, in session #2.1, "best known" should be supported by statistical reports. In session #3, "is thought to" should not be allowed.

References are reliable except the Reference 4. When the compound was described in the 1930’s, did researchers publish articles about this compound?

There is a lack of reference about the solubility of zinc pyrithione in water. In addition, is zinc pyrithione soluble in lipids? There is also a lack of reference about the use of zinc pyrithione in paints.XiaoMMMZhao (talk) 15:18, 25 October 2016 (UTC)[reply]

Well anyone can edit. Just try to use general references (books, reviews) and avoid conflict of interest (WP:COI). Those kinds of problems seem to apply to editors who are intensely interested in a few topics.

Vitiligo[edit]

I think the claim that zinc pyrithione treats vitiligo is mistaken. It does treat the fungal infection T. versicolor, which mimics vitiligo, but I'm almost certain it will not treat vitiligo. 74.196.122.198 (talk) 18:46, 30 September 2022 (UTC)[reply]

[1] Lamore, Sarah; Cabello, Christopher; Wondrak, Georg (Oct 7, 2009). "The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in cultured human skin cells". Cell Stress Chaperones. 13 (3): 309–322. doi:10.1007/s12192-009-0145-6. PMID 19809895.

[2] Qian, Pei-Yuan; Chen, Lianguo; Xu, Ying (Apr 10, 2013). "Mini-review: Molecular mechanisms of antifouling compounds". Biofouling. 29 (4): 392, 393. doi:10.1080/08927014.2013.776546.

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