Talk:Wallerian degeneration

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Second paragraph[edit]

The second paragraph seems out of place in this page. "The nerve fiber's neurolemma does not degenerate and remains as a hollow tube. Within 96 hours of the injury, the proximal end of the nerve fiber sends out sprouts towards those tubes and these sprouts are attracted by growth factors produced by Schwann cells in the tubes. If a sprout reaches the tube, it grows into it and advances about 3-4 mm per day, eventually reaching and reinnervating the target tissue. If the sprouts cannot reach the tube, for instance because the gap is too wide or scar tissue has formed, surgery can help to guide the sprouts into the tubes. This regeneration however happens only in peripheral nerves, not in the spinal cord. The crucial difference is that in the central nervous system, including in the spinal chord, myelin sheaths are produced by oligodendrocytes and not by Schwann cells." . The discussion of regeneration in the peripheral and central nervous systems is so general it could be misleading. Sprouting does occur in the CNS in humans and animals and causes compensation after injury. (NeuroHistol 23:16, 8 February 2007 (UTC)).

I agree. I'm baffled when reading the second paragraph - what grows where and why the text on regeneration is included in the beginning of the article on degeneration. --CopperKettle 11:10, 12 February 2009 (UTC)[reply]

MeSH term link[edit]

I have included an infobox with the MeSH term, but the link does not work properly. Would be glad if anybody fixes it. Please note that the same in included in a different format in the External links section which needs to be removed after the task is accomplished. Diptanshu^Talk 19:17, 10 August 2013 (UTC)[reply]

Updating the page[edit]

A decent amount of new literature has been published that has not yet been included in this page. Particularly, the role of SARM1 and other proteins in the pathway is much better understood, providing a better understanding for the important of NAD+ and NMNAT proteins. Would appreciate any help editing or fact checking the new information I am adding. --WikiAidan (talk) 18:36, 9 August 2018 (UTC)[reply]