Talk:Tricine

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Low-importance).

Chemicals Low‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
Low	This article has been rated as Low-importance on the project's importance scale.

Untitled[edit]

Isn't tricine used to buffer solutions near neutral? If so, shouldn't it have a pKa near neutral? Current article only lists a very acidic pKa. ike9898 18:02, 21 November 2006 (UTC)[reply]

I've linked to a Good paper from Biochemistry in 1966. Technically, the article is right --- pKa1 is 2.3, but that's not the relevant pKa. That would be pKa2, which is 8.15 at 20c. I've changed accordingly and referenced. --18.103.24.174 00:21, 15 August 2007 (UTC)[reply]

The chemical structure is impossible -- at no pH would the COO be protonated while the NH is deprotonated. Valid protonation states are either positive (NH2+, COOH), negative (NH, COO-), or zwiterionic (NH2+, COO-). Nfitzkee (talk) 20:10, 28 November 2011 (UTC)[reply]