Talk:TRIM21

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Time to update and fix up this page[edit]

This will probably become an important page soon. Seem this protein is what activates virus killing inside a cell. As in, big discovery about it. http://www.independent.co.uk/news/science/a-cure-for-the-common-cold-may-finally-be-achieved-as-a-result-of-a-remarkable-discovery-in-a-cambridge-laboratory-2122607.html FX (talk) 15:13, 2 November 2010 (UTC)[reply]

Crystal Structure Corrections[edit]

I went digging for the source of the crystal structure shown on the page, and I noticed it's not actually the complete structure of TRIM21; rather, the globs in the corners are the PRYSPRY domains of two TRIM21 proteins, and the double column in the middle is the Fc domain of an antibody.^[1] Is there a particular way to fix this, given that there doesn't seem to be a complete structure of TRIM21?

2601:41:4002:CA99:0:0:0:BC6B (talk) 02:41, 29 November 2016 (UTC)[reply]

References

^ James LC et al, PNAS 2007 doi: 10.1073/pnas.0609174104

After reading articles about the subject, i’m pretty sure that TRIM21 is degraded in the process of proteolysis. Unlike as suggested in the wiki.

[1] James LC et al, PNAS 2007 doi: 10.1073/pnas.0609174104

[1]