Talk:SNARE protein

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Molecular Biology: MCB

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Wiki Education Foundation-supported course assignment[edit]

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Sivart13. Peer reviewers: OMM93.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 08:30, 17 January 2022 (UTC)[reply]

Zippering and Fusion Pore Opening[edit]

The section on fusion pore opening does not address the possibility for a protein based fusion pore. Because neither side can definitively say by what mechanism the fusion pore is created by, it might be a good idea to include information on both the immediate membrane fusion and the protein pore theories. Biophysman (talk) 15:54, 8 October 2015 (UTC)[reply]

zero ionic layer[edit]

In the paragraph explaining the zero ionic layer the article says "...interact with the carboxyl groups of each of the three glutamine (Q) residues." Glutamine has an amide side chain functional group. But the arginine could interact with the carbonyl oxygen from the amide side chains. Could somebody check in the crystal structure? 84.57.36.226 (talk) 20:55, 18 March 2011 (UTC)[reply]

"The positively charged guanidino groups of the arginine residue interact with carboxyl groups from each of the three glutamine residues." citation from page 350 of the article: Sutton RB, Fasshauer D, Jahn R, Brunger AT (1998) Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature 395: 347-353. Their Figure 3 shows clearly the arginine interaction with the oxygen from the amide group of the Glutamine side chain, but "carboxyl group" is the exact word published in Nature. It is possible that the authors who published in Nature made a typo carboxyl instead of carbonyl. I have revised the article main text to fix that. Danko Georgiev (talk) 09:27, 1 January 2012 (UTC)[reply]

Hi, Can I modify this part of the article by adding a picture captured when I was using Pymol to launch the zero ionic layer complex? The picture has a clear demonstration of the 3Q:1R orientation, which could help explain this concept. I will add some further details about Zero Ionic Layer too, because I found several scientific papers that were dedicated to this topic. --Yinhanliu (talk) 20:20, 15 February 2018 (UTC)[reply]

I created a new article about zero ionic layer, but one reviewer removed my article and directed it here, probably because I just created it and was still under the information integration stage so I didn't post all the information on that article. Do you think I should still keep that page? I think if I add all the information here, it will be too detailed for "SNARE". I would appreciate your suggestion. -- Yinhanliu (talk) 20:43, 15 February 2018 (UTC)[reply]

Update 5/2/13[edit]

I've updated the page to include more information about its associations and how it acts as a fusion clamp. Dhaimes3907 (talk) 20:32, 2 May 2013 (UTC)[reply]

Suggestion[edit]

The AAA-ATPase Link leads to no page. Perhaps "NSF" could be linked to "N-ethylmaleimide sensitive fusion protein" article written about it. Harris.qureshi (talk) 19:50, 23 January 2015 (UTC)[reply]

Suggestion: a list of known human/mammalian genes[edit]

Basically the title. It would be nice to have a sorted list (distinguishing between neuronal tissue and other tissues). CaffeineWitcher (talk) 09:59, 12 February 2021 (UTC)[reply]