Talk:Neurosteroid

Physiology Mid‑importance

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Molecular Biology: MCB

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Neuroactive Steroid vs. Neurosteroid[edit]

Neuroactive Steroids in the literature are generally not considered the same as Neurosteroids -- See Reference 6 on this page.

Neuroactive steroids are steroids made in the periphery that affect brain function themselves or following conversion to another steroid in the brain. Examples would be glucocorticoids made by the adrenal gland that directly affect brain activity or testosterone in the male which is converted to estrogen in the brain and then alters brain development. Neurosteroids are any steroid made from cholesterol (de novo) in the brain. Furthermore, Neuroactive Steroids in many cases use a different mechanism of action to affect brain function than do Neurosteroids.

One could argue neurosteroids are a type of neuroactive steroid, though that might be very confusing. Indeed, therapeutic uses of neurosteroids blur the line.

Either way, this page should either be divided into two pages or re-organized. Skingski (talk) 17:15, 6 August 2009 (UTC)[reply]

Good point. It appears that the material in this article is primarily about neurosteroids and to a lesser degree, neuroactive steroids. Unless we split this article into two, it would make sense to rename it to neurosteroid. Boghog2 (talk) 17:56, 6 August 2009 (UTC)[reply]

Agreed. Then the question is, does "neuroactive steroid" deserve its own page or is that a topic that can be discussed on the steroid hormone page? Skingski (talk) 18:35, 6 August 2009 (UTC)[reply]

Ganaxolone[edit]

The last sentence of the introduction reads: "Ganaxolone, a synthetic analog of the endogenous neurosteroid allopregnanolone, is under investigation for the treatment of epilepsy." Why is this called out in the intro? I don't any particular neurosteroid or analog needs to be called out in the introduction. Please remove. --1000Faces (talk) 02:30, 20 March 2021 (UTC)[reply]

Neurosteroid's short description needs revision[edit]

The term neurosteroid was coined by the French physiologist... The term, neuroactive steroid refers to steroids... The term neuroactive steroids was first coined in 1992 by Steven... Neurosteroids...

Two sentences that contradict and they all start the same way made for repetitive reading.

I only rarely make an edit sorry if this is not the proper format or etiquette to ask that this page get an update/revision. NONSquall (talk) 19:26, 27 August 2023 (UTC)[reply]