Talk:Live vector vaccine

There already exists a page called Attenuated_virus that covers the topic of live vector vaccines. Shouldn´t this page about Live vector vaccines become a redirect to Attenuated_virus? —Preceding unsigned comment added by Trujaman (talk • contribs) 05:56, 25 April 2009 (UTC)

Probably not. The topic is large and important, and this article barely scratches the surface. It is not currently covered under the attenuated vaccine article, which itself is very limited. Espresso Addict (talk) 01:08, 11 January 2013 (UTC)

Is it just viruses?

I thought that (eg) bacteria could also be used as the vector.

As I understand it, antigens for vaccines can be produced by geneticall engineering other organisms to produce the antigens. The organisms can include: plants (tobacco plants are popular, I think because they grow quickly so a lot of antigen can be harvested quickly); yeasts; bacteria; and viruses.

Antigens can be produced this way to be harvested and used in conventional vaccines.

Antigens can also be used to vaccinate them by consuming foods containing the antigens (particularly if the pathogen you want to protect against usually enters or operates within the digestive tract), or by injecting or otherwise administering (eg by nasal spray) the live microorganism which is the vector for the genes expressing the antigen. In theory, any vector organism which can be safely administered this way could be used - bacteria, yeast, virus, rickettsia... One disadvantage of this approach is that the person (or animal if thinking of veterinary practice) will become immune to the microorganism which is the vector, which probably limits such approaches to a single use, as the person will likely develop immunity to the vector organism.

peter_english (talk) 12:11, 27 November 2017 (UTC)

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